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Paper200699

Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors.

Granelli-Piperno A and 2 others. J Exp Med, 1977. Cited by 254 papers, by iCite.

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ConductScience Library. Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors. Papers, record 200699. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/200699

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
254
iCite
Relative citation ratio, by iCite
7.88
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Granelli-Piperno AA
2Vassalli JDJ D
3Reich EE

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
NeutrophilsMajor topic
Plasminogen ActivatorsMajor topic
Cyclic AMP
Dexamethasone
Fibrinolysis
Glucocorticoids
Pancreatic Elastase
Tetradecanoylphorbol Acetate

Source PubMed

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
161,067Macrophage plasminogen activator: modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides.Cell1976https://conductscience.org/library/papers/61067PubMed
2235,318Cationic proteins from human neutrophil granulocytes. Evidence for their chymotrypsin-like properties.Biochim Biophys Acta1975https://conductscience.org/library/papers/235318PubMed
3236,354Subcellular localization and heterogeneity of neutral proteases in neutrophilic polymorphonuclear leukocytes.J Exp Med1975https://conductscience.org/library/papers/236354PubMed
4833,546Macrophage plasminogen activator: induction by products of activated lymphoid cells.J Exp Med1977https://conductscience.org/library/papers/833546PubMed
5869,181A sensitive assay for elastase employing radioactive elastin coupled to sepharose.Anal Biochem1977https://conductscience.org/library/papers/869181PubMed
6884,740Macrophage plasminogen activator: induction by concanavalin A and phorbol myristate acetate.Cell1977https://conductscience.org/library/papers/884740PubMed
7965,386Studies on the role of plasminogen activator in ovulation. In vitro response of granulosa cells to gonadotropins, cyclic nucleotides, and prostaglandins.J Biol Chem1976https://conductscience.org/library/papers/965386PubMed
81,003,109Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids.J Exp Med1976https://conductscience.org/library/papers/1003109PubMed
91,008,053Inhibition of murine granulopoiesis in vitro by dexamethasone.Am J Hematol1976https://conductscience.org/library/papers/1008053PubMed
101,025,156Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes.J Cell Biol1976https://conductscience.org/library/papers/1025156PubMed
111,158,973Mechanisms of lysosomal enzyme release from human polymorphonuclear leukocytes. Effects of phorbol myristate acetate.J Cell Biol1975https://conductscience.org/library/papers/1158973PubMed
121,260,119Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes.Blood1976https://conductscience.org/library/papers/1260119PubMed
134,119,468Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase.J Clin Invest1973https://conductscience.org/library/papers/4119468PubMed
144,145,342Reversible metabolic stimulation of polymorphonuclear leukocytes and macrophages by concanavalin A.Nat New Biol1973https://conductscience.org/library/papers/4145342PubMed
154,208,353The neutral proteases of human granulocytes. Isolation and partial characterization of granulocyte elastases.Eur J Biochem1974https://conductscience.org/library/papers/4208353PubMed
164,354,339The neutral proteases of human granulocytes. Isolation and partial characterization of two granulocyte collagenases.Eur J Biochem1973https://conductscience.org/library/papers/4354339PubMed
174,355,423Fibrinolysis associated with oncogenic transformation. Requirement of plasminogen for correlated changes in cellular morphology, colony formation in agar, and cell migration.J Exp Med1973https://conductscience.org/library/papers/4355423PubMed
184,421,315The influence of phorbol myristate acetate on oxygen consumption by polymorphonuclear leukocytes.J Lab Clin Med1974https://conductscience.org/library/papers/4421315PubMed
194,427,092Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis: evidence for a two-stage process.J Exp Med1974https://conductscience.org/library/papers/4427092PubMed
204,500,454Effect of concanavalin A on phagocytosis.Nat New Biol1972https://conductscience.org/library/papers/4500454PubMed

See all 35 references

Cited by61

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 254 citations.

PMIDTitleJournalYearIn PapersSource
39,396,093Development of a nomogram for deep vein thrombosis in patients with tibial plateau fractures based on systemic Immune-inflammation index.Sci Rep2024https://conductscience.org/library/papers/39396093PubMed
38,558,749Review of the Association Between Long-Term and Current Systemic Steroid Use With Electromechanical Complications and Inpatient Mortality After ST-Elevation Myocardial Infarction.Cureus2024https://conductscience.org/library/papers/38558749PubMed
38,539,173Construction of a nomogram model for deep vein thrombosis in patients with tibial plateau fracture based on the Systemic Inflammatory Response Index.BMC Musculoskelet Disord2024https://conductscience.org/library/papers/38539173PubMed
37,525,162Association between inflammatory biomarkers and venous thromboembolism: a systematic review and meta-analysis.Thromb J2023https://conductscience.org/library/papers/37525162PubMed
35,444,662Inflammation in Cerebral Venous Thrombosis.Front Immunol2022https://conductscience.org/library/papers/35444662PubMed
34,381,415Time Course of Peripheral Leukocytosis and Clinical Outcomes After Aneurysmal Subarachnoid Hemorrhage.Front Neurol2021https://conductscience.org/library/papers/34381415PubMed
32,396,717Alpha-1 Antitrypsin Deficiency: Have We Got the Right Proteinase?Chronic Obstr Pulm Dis2020https://conductscience.org/library/papers/32396717PubMed
29,556,269Leukocyte depletion does not affect the in vitro healing ability of platelet rich plasma.Exp Ther Med2018https://conductscience.org/library/papers/29556269PubMed
25,136,628Evaluation of the efficacy of 50% autologous serum eye drops in different ocular surface pathologies.Biomed Res Int2014https://conductscience.org/library/papers/25136628PubMed
18,686,734Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease.Int J Chron Obstruct Pulmon Dis2008https://conductscience.org/library/papers/18686734PubMed
15,042,374Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator.Histochem Cell Biol2004https://conductscience.org/library/papers/15042374PubMed
10,431,800The appearance and possible role of plasminogen activator of urokinase type (u-PA) activity in the cornea related to soft contact lens wear in rabbits.Doc Ophthalmol1998https://conductscience.org/library/papers/10431800PubMed
9,137,094Role of endothelial selectins in wound repair.Am J Pathol1997https://conductscience.org/library/papers/9137094PubMed
8,203,466Plasminogen activation in healing human wounds.Am J Pathol1994https://conductscience.org/library/papers/8203466PubMed
7,870,631Corticosteroids: do they damage the cardiovascular system?Postgrad Med J1994https://conductscience.org/library/papers/7870631PubMed
7,682,051Plasminogen activation in lesional skin of Pemphigus vulgaris type Neumann.Arch Dermatol Res1993https://conductscience.org/library/papers/7682051PubMed
7,400,219Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages.J Cell Biol1980https://conductscience.org/library/papers/7400219PubMed
7,192,286Plasminogen activator induction and platelet aggregation by phorbol and some of its derivatives: correlation with skin irritancy and tumor-promoting activity.J Cancer Res Clin Oncol1980https://conductscience.org/library/papers/7192286PubMed
7,039,879Characteristics of fibrinolytic enzyme release from human monocytes.Clin Exp Immunol1981https://conductscience.org/library/papers/7039879PubMed
7,001,479Cleavage of fibrinogen by the human neutrophil neutral peptide-generating protease.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/7001479PubMed

See all 61 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
PLG5,340PubTator's text mininghttps://conductscience.org/library/genes/5340

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • ClinicalTrials.govNo license stated
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  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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