Paper · 2011597

A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes.

Fukuoka S and 2 others. Proc Natl Acad Sci U S A, 1991. Cited by 97 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes. Papers, record 2011597. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2011597

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1991; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2011597/; PubMed
DOI: https://doi.org/10.1073/pnas.88.7.2898; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC51347/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 97; iCite
Relative citation ratio, by iCite: 2.4; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Fukuoka S	S
2	Freedman SD	S D
3	Scheele GA	G A

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cytoplasmic Granules	Major topic
Intracellular Membranes	Major topic
Membrane Glycoproteins	Major topic
Pancreas	Major topic
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Dogs
Gene Library
Molecular Sequence Data
Oligonucleotide Probes
Peptide Mapping
Polymerase Chain Reaction
Protein Conformation

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
DDK-18532-17	NIDDK NIH HHS	United States		PubMed	PubMed
T32-07524	PHS HHS	United States		PubMed	PubMed
			R01DK018532	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,852,052	Biosynthesis of the major glycoprotein associated with zymogen-granule membranes in the pancreas.	Eur J Biochem	1983	https://conductscience.org/library/papers/6852052	PubMed
2	6,279,313	Two distinct intracellular pathways transport secretory and membrane glycoproteins to the surface of pituitary tumor cells.	Cell	1982	https://conductscience.org/library/papers/6279313	PubMed
3	6,696,900	The integral and peripheral proteins of the zymogen granule membrane.	Biochim Biophys Acta	1984	https://conductscience.org/library/papers/6696900	PubMed
4	6,696,901	Identification of the proteins exposed on the cytoplasmic surface of the pancreatic zymogen granule.	Biochim Biophys Acta	1984	https://conductscience.org/library/papers/6696901	PubMed
5	6,479,170	Intracellular transport of the major glycoprotein of zymogen granule membranes in the rat pancreas. Demonstration of high turnover at the plasma membrane.	Eur J Biochem	1984	https://conductscience.org/library/papers/6479170	PubMed
6	2,989,096	Nucleotide sequence of a major class-III phage-T3 RNA-polymerase promoter located at 98.0% of phage-T3 genetic map.	Gene	1985	https://conductscience.org/library/papers/2989096	PubMed
7	3,474,623	DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.	Proc Natl Acad Sci U S A	1987	https://conductscience.org/library/papers/3474623	PubMed
8	3,611,052	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	J Biol Chem	1987	https://conductscience.org/library/papers/3611052	PubMed
9	2,889,741	High lateral mobility of endogenous and transfected alkaline phosphatase: a phosphatidylinositol-anchored membrane protein.	J Cell Biol	1987	https://conductscience.org/library/papers/2889741	PubMed
10	3,313,383	Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose.	Proc Natl Acad Sci U S A	1987	https://conductscience.org/library/papers/3313383	PubMed

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Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 97 citations.

PMID	Title	Journal	Year	In Papers	Source
38,170,255	Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.	Semin Immunopathol	2024	https://conductscience.org/library/papers/38170255	PubMed
38,087,030	Rab7 localized on zymogen granules is involved in maturation but not in autophagy or regulated exocytosis in pancreatic acinar cells.	Sci Rep	2023	https://conductscience.org/library/papers/38087030	PubMed
27,760,104	Epithelial glycosylation in gut homeostasis and inflammation.	Nat Immunol	2016	https://conductscience.org/library/papers/27760104	PubMed
26,634,447	Intestinal M cells.	J Biochem	2016	https://conductscience.org/library/papers/26634447	PubMed
25,516,642	Genetic and phenotypic heterogeneity in tropical calcific pancreatitis.	World J Gastroenterol	2014	https://conductscience.org/library/papers/25516642	PubMed
24,695,378	CDKAL1-related single nucleotide polymorphisms are associated with insulin resistance in a cross-sectional cohort of Greek children.	PLoS One	2014	https://conductscience.org/library/papers/24695378	PubMed
23,118,780	Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease.	Clin Dev Immunol	2012	https://conductscience.org/library/papers/23118780	PubMed
21,468,225	Glycoprotein 2 (GP2): grabbing the FimH bacteria into M cells for mucosal immunity.	Gut Microbes	2010	https://conductscience.org/library/papers/21468225	PubMed
19,627,615	The pancreatic zymogen granule membrane protein, GP2, binds Escherichia coli Type 1 fimbriae.	BMC Gastroenterol	2009	https://conductscience.org/library/papers/19627615	PubMed
19,529,781	Identification of a novel uromodulin-like gene related to predator-induced bulgy morph in anuran tadpoles by functional microarray analysis.	PLoS One	2009	https://conductscience.org/library/papers/19529781	PubMed

1 to 10 of 22

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
GP2	2,813	PubTator's text mining	https://conductscience.org/library/genes/2813

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data11

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession	Source
GENBANK	D90291	GENBANK
GENBANK	D90292	GENBANK
GENBANK	D90293	GENBANK
GENBANK	D90294	GENBANK
GENBANK	D90295	GENBANK
GENBANK	D90296	GENBANK
GENBANK	D90297	GENBANK
GENBANK	D90298	GENBANK
GENBANK	M37038	GENBANK
GENBANK	M60469	GENBANK

1 to 10 of 11

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Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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