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Paper · 20150372

A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy.

Raizer JJ and 18 others. Neuro Oncol, 2010. Cited by 219 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Papers, record 20150372. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20150372

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy.
PubMed
Journal
Neuro Oncol
PubMed
Year
2010
PubMed
Publication types
Clinical Trial, Phase II, Journal Article, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
219
iCite
Relative citation ratio, by iCite
5.29
iCite
Revised in PubMed
2025-05-29
PubMed

Authors19

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Raizer JJJeffrey J
2Abrey LELauren E
3Lassman ABAndrew B
4Chang SMSusan M
5Lamborn KRKathleen R
6Kuhn JGJohn G
7Yung WKW K Alfred
8Gilbert MRMark R
9Aldape KAKenneth A
10Wen PYPatrick Y

1 to 10 of 19Source PubMed

See all 19 authors

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antineoplastic AgentsMajor topic
Brain NeoplasmsMajor topic
GlioblastomaMajor topic
GliomaMajor topic
QuinazolinesMajor topic
Adult
Aged
Disease-Free Survival
Erlotinib Hydrochloride
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Recurrence, Local
Tissue Distribution

Source PubMed

Grants19

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
UL1 TR000005NCATS NIH HHSUnited StatesUL1TR000005PubMed and NIHNIH RePORTER
M01-RR0865NCRR NIH HHSUnited StatesM01RR000865PubMed and NIHNIH RePORTER
M01-RR00079NCRR NIH HHSUnited StatesM01RR000079PubMed and NIHNIH RePORTER
U01CA62407-08NCI NIH HHSUnited StatesU01CA624070PubMedNIH RePORTER
CA16672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
5-U01CA62399-09NCI NIH HHSUnited StatesU01CA623990PubMedNIH RePORTER
M01-RR00056NCRR NIH HHSUnited StatesM01RR000056PubMed and NIHNIH RePORTER
CA62422NCI NIH HHSUnited StatesU01CA062422PubMed and NIHNIH RePORTER
U01CA62405NCI NIH HHSUnited StatesU01CA062405PubMed and NIHNIH RePORTER
CA62399NCI NIH HHSUnited StatesU01CA062399PubMed and NIHNIH RePORTER

1 to 10 of 19

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
117,255,257PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors.Clin Cancer Res2007https://conductscience.org/library/papers/17255257PubMed
22,358,840Response criteria for phase II studies of supratentorial malignant glioma.J Clin Oncol1990https://conductscience.org/library/papers/2358840PubMed
315,758,016Chemotherapy for brain tumors--a new beginning.N Engl J Med2005https://conductscience.org/library/papers/15758016PubMed
415,753,462
Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer.
J Clin Oncol2005https://conductscience.org/library/papers/15753462PubMed
516,626,884Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177.Int J Radiat Oncol Biol Phys2006https://conductscience.org/library/papers/16626884PubMed
617,177,598Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.PLoS Med2006https://conductscience.org/library/papers/17177598PubMed
720,510,539Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074.Int J Radiat Oncol Biol Phys2011https://conductscience.org/library/papers/20510539PubMed
89,407,626Molecular changes during the genesis of human gliomas.Semin Surg Oncol1998https://conductscience.org/library/papers/9407626PubMed
919,204,207Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034.J Clin Oncol2009https://conductscience.org/library/papers/19204207PubMed
1016,278,407Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.Clin Cancer Res2005https://conductscience.org/library/papers/16278407PubMed

1 to 10 of 35

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Cited by150

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 219 citations.

PMIDTitleJournalYearIn PapersSource
42,958,602Glioblastoma as a dynamic tumor ecosystem: from molecular alterations to therapeutic translation.Exp Hematol Oncol2026https://conductscience.org/library/papers/42958602PubMed
42,824,982Receptor tyrosine kinase targeted therapies in glioblastoma: a systematic review.Front Med (Lausanne)2026https://conductscience.org/library/papers/42824982PubMed
42,281,808Applications of transcranial focused ultrasound for primary brain tumors.Neurooncol Adv2026https://conductscience.org/library/papers/42281808PubMed
41,684,840Metabolic reprogramming and immunosenescence: a new sight for glioma therapy.Front Cell Dev Biol2026https://conductscience.org/library/papers/41684840PubMed
40,945,534Biodegradable nanofibrous scaffolds enhance standard of care for glioblastoma via localized targeted therapy.J Control Release2025https://conductscience.org/library/papers/40945534PubMed
40,358,199Targeting Glioma Stem Cells: Therapeutic Opportunities and Challenges.Cells2025https://conductscience.org/library/papers/40358199PubMed
39,796,751Advances in Glioblastoma Diagnosis: Integrating Genetics, Noninvasive Sampling, and Advanced Imaging.Cancers (Basel)2025https://conductscience.org/library/papers/39796751PubMed
39,408,897Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma.Int J Mol Sci2024https://conductscience.org/library/papers/39408897PubMed
39,329,757Metabolic Reprogramming in Glioblastoma Multiforme: A Review of Pathways and Therapeutic Targets.Cells2024https://conductscience.org/library/papers/39329757PubMed
39,143,272Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors.NPJ Precis Oncol2024https://conductscience.org/library/papers/39143272PubMed

1 to 10 of 150

See all 150 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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