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Paper · 201776

Slow switchover from host RNA synthesis to bacteriophage RNA synthesis after infection of Escherichia coli with a T4 mutant defective in the bacteriophage T4-induced unfolding of the host nucleoid.

Tigges MA and 2 others. J Virol, 1977. Cited by 14 papers, by iCite.

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ConductScience Library. Slow switchover from host RNA synthesis to bacteriophage RNA synthesis after infection of Escherichia coli with a T4 mutant defective in the bacteriophage T4-induced unfolding of the host nucleoid. Papers, record 201776. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/201776

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Slow switchover from host RNA synthesis to bacteriophage RNA synthesis after infection of Escherichia coli with a T4 mutant defective in the bacteriophage T4-induced unfolding of the host nucleoid.
PubMed
Journal
J Virol
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
14
iCite
Relative citation ratio, by iCite
0.4
iCite
Revised in PubMed
2020-07-24
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Tigges MAM A
2Bursch CJC J
3Snustad DPD P

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ColiphagesMajor topic
Escherichia coliMajor topic
Genes, ViralMajor topic
RNA, BacterialMajor topic
RNA, ViralMajor topic
Cell Nucleus
DNA, Bacterial
Genetic Complementation Test
Mutation
Nucleoside-Phosphate Kinase
Transcription, Genetic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
114,405,215Electron microscopical studies of phage multiplication. IV. The establishment of the DNA pool of vegetative phage and the maturation of phage particles.Virology1959https://conductscience.org/library/papers/14405215PubMed
514,006,693Early enzyme synthesis and its control in E. coli infected with some amber mutants of bacteriophage T4.Proc Natl Acad Sci U S A1962https://conductscience.org/library/papers/14006693PubMed
613,916,671A critical test of a current theory of genetic recombination in bacteriophage.Genetics1962https://conductscience.org/library/papers/13916671PubMed
13834,238T4 Bacteriophage-coded RNA polymerase subunit blocks host transcription and unfolds the host chromosome.Nature1977https://conductscience.org/library/papers/834238PubMed
14321,802Shutoff of host RNA synthesis in bacteriophage T4-infected Escherichia coli in the absence of host DNA degradation and nuclear disruption.J Virol1977https://conductscience.org/library/papers/321802PubMed
15319,455Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/319455PubMed
16787,764Phage T4 infection restricts rRNA synthesis by E. coli RNA polymerase.Mol Gen Genet1976https://conductscience.org/library/papers/787764PubMed
17787,760Modulation of RNA polymerase specificity by ppGpp.Mol Gen Genet1976https://conductscience.org/library/papers/787760PubMed
181,067,605A gene of bacteriophage T4 whose product prevents true late transcription on cytosine-containing T4 DNA.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1067605PubMed
194,114,321Nuclear disruption after infection of Escherichia coli with a bacteriophage T4 mutant unable to induce endonuclease II.J Virol1972https://conductscience.org/library/papers/4114321PubMed

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 14 citations.

PMIDTitleJournalYearIn PapersSource
7,321,103Bacteriophage T4 alc gene product: general inhibitor of transcription from cytosine-containing DNA.J Virol1981https://conductscience.org/library/papers/7321103PubMed
6,447,802Shutoff of lambda gene expression by bacteriophage T4: role of the T4 alc gene.J Virol1980https://conductscience.org/library/papers/6447802PubMed
6,177,866Plasmid pR386 renders Escherichia coli cells restrictive to the growth of bacteriophage T4 unf mutants.J Virol1982https://conductscience.org/library/papers/6177866PubMed
3,783,815The bacteriophage T4 regulatory protein gpunf/alc binds to DNA in the absence of RNA polymerase.J Virol1986https://conductscience.org/library/papers/3783815PubMed
3,782,028Molecular proof that bacteriophage T4 alc and unf genes are the same gene.J Bacteriol1986https://conductscience.org/library/papers/3782028PubMed
3,282,983Escherichia coli mutations that prevent the action of the T4 unf/alc protein map in an RNA polymerase gene.Genetics1988https://conductscience.org/library/papers/3282983PubMed
2,578,570Bacteriophage T4 unf (=alc) gene function is required for late replication in the presence of plasmid pR386.J Virol1985https://conductscience.org/library/papers/2578570PubMed
390,354Shutoff of host macromolecular synthesis after T-even bacteriophage infection.Microbiol Rev1979https://conductscience.org/library/papers/390354PubMed
390,166Host transcription in bacteriophage P22-infected Salmonella typhimurium.J Virol1979https://conductscience.org/library/papers/390166PubMed
384,022Protein induced by bacteriophage T4 which is absent in Escherichia coli infected with nuclear disruption-deficient phage mutants.J Virol1979https://conductscience.org/library/papers/384022PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
ALLC55,821PubTator's text mininghttps://conductscience.org/library/genes/55821

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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