Paper · 20178992

Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing.

Tay YD and 1 other. J Biol Chem, 2010. Cited by 58 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing. Papers, record 20178992. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20178992

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing.; PubMed
Journal: J Biol Chem; PubMed
Year: 2010; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/20178992/; PubMed
DOI: https://doi.org/10.1074/jbc.m110.108399; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2857021/; PubMed
The journal: https://conductscience.org/library/journal-index/2985121R; PubMed
Citations, by iCite: 58; iCite
Relative citation ratio, by iCite: 1; iCite
Revised in PubMed: 2024-03-22; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Tay YD	Ye Dee
2	Wu L	Leonard

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA, Cruciform	Major topic
DNA-Binding Proteins	Major topic
Endonucleases	Major topic
Gene Expression Regulation, Fungal	Major topic
Holliday Junction Resolvases	Major topic
Saccharomyces cerevisiae	Major topic
Saccharomyces cerevisiae Proteins	Major topic
Cloning, Molecular
DNA Damage
DNA Repair
DNA Replication
Dimerization
Escherichia coli
Escherichia coli Proteins
Models, Biological
Plasmids
Radiation, Ionizing

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
	Cancer Research UK	United Kingdom		PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	11,719,193	Mus81-Eme1 are essential components of a Holliday junction resolvase.	Cell	2001	https://conductscience.org/library/papers/11719193	PubMed
2	19,595,722	Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination.	Mol Cell	2009	https://conductscience.org/library/papers/19595722	PubMed
3	19,596,236	Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.	Cell	2009	https://conductscience.org/library/papers/19596236	PubMed
4	19,442,243	Control of genome stability by SLX protein complexes.	Biochem Soc Trans	2009	https://conductscience.org/library/papers/19442243	PubMed
5	8,168,483	Xer-mediated site-specific recombination at cer generates Holliday junctions in vivo.	EMBO J	1994	https://conductscience.org/library/papers/8168483	PubMed
6	18,922,464	Mus81-dependent double-strand DNA breaks at in vivo-generated cruciform structures in S. cerevisiae.	Mol Cell	2008	https://conductscience.org/library/papers/18922464	PubMed
7	9,169,457	Sequence specificity and biochemical characterization of the RusA Holliday junction resolvase of Escherichia coli.	J Biol Chem	1997	https://conductscience.org/library/papers/9169457	PubMed
8	12,084,712	Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.	J Biol Chem	2002	https://conductscience.org/library/papers/12084712	PubMed
9	14,527,420	Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis.	Mol Cell	2003	https://conductscience.org/library/papers/14527420	PubMed
10	19,596,235	Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.	Cell	2009	https://conductscience.org/library/papers/19596235	PubMed

1 to 10 of 24

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Cited by46

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 58 citations.

PMID	Title	Journal	Year	In Papers	Source
40,920,868	A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation.	PLoS Genet	2025	https://conductscience.org/library/papers/40920868	PubMed
36,999,631	Flap endonuclease Rad27 cleaves the RNA of R-loop structures to suppress telomere recombination.	Nucleic Acids Res	2023	https://conductscience.org/library/papers/36999631	PubMed
35,910,852	Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib.	J Immunol Res	2022	https://conductscience.org/library/papers/35910852	PubMed
34,928,393	Canonical and novel non-canonical activities of the Holliday junction resolvase Yen1.	Nucleic Acids Res	2022	https://conductscience.org/library/papers/34928393	PubMed
33,322,845	Implications of Metastable Nicks and Nicked Holliday Junctions in Processing Joint Molecules in Mitosis and Meiosis.	Genes (Basel)	2020	https://conductscience.org/library/papers/33322845	PubMed
32,419,301	Homologous recombination and Mus81 promote replication completion in response to replication fork blockage.	EMBO Rep	2020	https://conductscience.org/library/papers/32419301	PubMed
31,936,378	Resolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation.	Genes (Basel)	2020	https://conductscience.org/library/papers/31936378	PubMed
30,897,139	Helicase/SUMO-targeted ubiquitin ligase Uls1 interacts with the Holliday junction resolvase Yen1.	PLoS One	2019	https://conductscience.org/library/papers/30897139	PubMed
30,893,921	Structure-Specific Endonucleases and the Resolution of Chromosome Underreplication.	Genes (Basel)	2019	https://conductscience.org/library/papers/30893921	PubMed
29,414,053	Collaboration in the actions of Brh2 with resolving functions during DNA repair and replication stress in Ustilago maydis.	DNA Repair (Amst)	2018	https://conductscience.org/library/papers/29414053	PubMed

1 to 10 of 46

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

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None in this release.

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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