Paper · 40920868

A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation.

Budzyk M and 3 others. PLoS Genet, 2025. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation. Papers, record 40920868. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40920868

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A novel DNA repair-independent role for Gen nuclease in promoting unscheduled polyploidy cell proliferation.; PubMed
Journal: PLoS Genet; PubMed
Year: 2025; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/40920868/; PubMed
DOI: https://doi.org/10.1371/journal.pgen.1011605; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12440172/; PubMed
The journal: https://conductscience.org/library/journal-index/101239074; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2025-09-18; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Budzyk M	Manon
2	Simon A	Anthony	https://orcid.org/0000-0001-8693-4186
3	Mace AS	Anne-Sophie
4	Basto R	Renata	https://orcid.org/0000-0001-5556-2770

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Polyploidy	Major topic
DNA Repair	Major topic
Cell Proliferation	Major topic
Drosophila Proteins	Major topic
Animals
DNA Damage
DNA Replication
Drosophila melanogaster
Homologous Recombination
Genomic Instability
Humans

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References53

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	24,436,049	Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.	Cancer Discov	2014	https://conductscience.org/library/papers/24436049	PubMed
2	28,369,583	Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.	Nucleic Acids Res	2017	https://conductscience.org/library/papers/28369583	PubMed
3	18,976,517	A mechanism for gene conversion in fungi.	Genet Res	2007	https://conductscience.org/library/papers/18976517	PubMed
4	31,708,395	Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells.	Curr Biol	2019	https://conductscience.org/library/papers/31708395	PubMed
5	2,463,465	Structure and expression of ubiquitin genes of Drosophila melanogaster.	Mol Cell Biol	1988	https://conductscience.org/library/papers/2463465	PubMed
6	21,962,513	Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis.	Cell	2011	https://conductscience.org/library/papers/21962513	PubMed
7	21,172,663	Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.	Mol Cell	2010	https://conductscience.org/library/papers/21172663	PubMed
8	35,355,016	Genetic instability from a single S phase after whole-genome duplication.	Nature	2022	https://conductscience.org/library/papers/35355016	PubMed
9	25,921,783	When bigger is better: the role of polyploidy in organogenesis.	Trends Genet	2015	https://conductscience.org/library/papers/25921783	PubMed
10	17,024,086	Genome-wide genetic analysis of polyploidy in yeast.	Nature	2006	https://conductscience.org/library/papers/17024086	PubMed

1 to 10 of 53

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
GEN1	348,654	PubTator's text mining	https://conductscience.org/library/genes/348654

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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