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Paper · 35355016

Genetic instability from a single S phase after whole-genome duplication.

Gemble S and 15 others. Nature, 2022. Cited by 116 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Genetic instability from a single S phase after whole-genome duplication. Papers, record 35355016. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35355016

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Genetic instability from a single S phase after whole-genome duplication.
PubMed
Journal
Nature
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
116
iCite
Relative citation ratio, by iCite
7.32
iCite
Revised in PubMed
2022-09-09
PubMed

Authors16

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gemble SSimonhttps://orcid.org/0000-0002-4351-7136
2Wardenaar RRenéhttps://orcid.org/0000-0001-9891-1897
3Keuper KKristinahttps://orcid.org/0000-0002-9841-5516
4Srivastava NNishithttps://orcid.org/0000-0003-4177-6123
5Nano MMaddalena
6Macé ASAnne-Sophie
7Tijhuis AEAndréa E
8Bernhard SVSara Vanessa
9Spierings DCJDiana C Jhttps://orcid.org/0000-0001-8403-474X
10Simon AAnthony

1 to 10 of 16Source PubMed

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Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Chromosomal InstabilityMajor topic
DNA DamageMajor topic
Gene DuplicationMajor topic
S PhaseMajor topic
TetraploidyMajor topic
DNA Replication
Humans
Karyotype
Mitosis

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections3

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Erratum in35,864,235Author Correction: Genetic instability from a single S phase after whole-genome duplication.https://conductscience.org/library/papers/35864235PubMed
Comment in35,354,975Genome doubling causes double trouble.https://conductscience.org/library/papers/35354975PubMed
Comment in35,490,031Catastrophic DNA replication in unscheduled tetraploid cells.https://conductscience.org/library/papers/35490031PubMed

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
124,071,852Pan-cancer patterns of somatic copy number alteration.Nat Genet2013https://conductscience.org/library/papers/24071852PubMed
230,013,179Genome doubling shapes the evolution and prognosis of advanced cancers.Nat Genet2018https://conductscience.org/library/papers/30013179PubMed
332,139,907Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.Nat Genet2020https://conductscience.org/library/papers/32139907PubMed
419,020,304The consequences of tetraploidy and aneuploidy.J Cell Sci2008https://conductscience.org/library/papers/19020304PubMed
514,708,009From polyploidy to aneuploidy, genome instability and cancer.Nat Rev Mol Cell Biol2004https://conductscience.org/library/papers/14708009PubMed
624,436,049Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.Cancer Discov2014https://conductscience.org/library/papers/24436049PubMed
720,952,538Error-prone polyploid mitosis during normal Drosophila development.Genes Dev2010https://conductscience.org/library/papers/20952538PubMed
832,328,633Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells.J Cell Biol2020https://conductscience.org/library/papers/32328633PubMed
916,222,300Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells.Nature2005https://conductscience.org/library/papers/16222300PubMed
1025,921,783When bigger is better: the role of polyploidy in organogenesis.Trends Genet2015https://conductscience.org/library/papers/25921783PubMed

1 to 10 of 47

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Cited by94

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 116 citations.

PMIDTitleJournalYearIn PapersSource
42,962,034Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors.Sci Adv2026https://conductscience.org/library/papers/42962034PubMed
42,951,908Tubulin acetylation regulates nuclear shape fluctuations and DNA repair.Nat Cell Biol2026https://conductscience.org/library/papers/42951908PubMed
42,870,252Atypical fusion among non-malignant cells: Unveiling the link between post-fusion-induced genome chaos and cancer initiation.Cancer Cell Int2026https://conductscience.org/library/papers/42870252PubMed
42,855,540Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding.Nat Cell Biol2026https://conductscience.org/library/papers/42855540PubMed
42,836,275Manipulation of the cell cycle by HIV-1.Biochem Soc Trans2026https://conductscience.org/library/papers/42836275PubMed
42,784,505A transcription factor regulates development of a bacteria-housing eukaryotic cell through DNA damage mitigation.Proc Natl Acad Sci U S A2026https://conductscience.org/library/papers/42784505PubMed
42,763,345Whole genome duplication through mitotic slippage causes nuclear instability.EMBO J2026https://conductscience.org/library/papers/42763345PubMed
42,760,281Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42760281PubMed
42,634,949A Novel Role of DELTEX2 in Maintaining Genomic Stability of Granulosa Cells During Ovarian Aging.FASEB J2026https://conductscience.org/library/papers/42634949PubMed
42,589,329Inflamed Yet Immune-Evasive? A Transcriptomic Meta-Analysis Identifies Conserved Inflammatory, Developmental, and Neuronal Signatures Associated with Polyploid Giant Cancer Cells.Int J Mol Sci2026https://conductscience.org/library/papers/42589329PubMed

1 to 10 of 94

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Genes21

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CCNA2890PubTator's text mininghttps://conductscience.org/library/genes/890NCBI Gene
CCNB1891PubTator's text mininghttps://conductscience.org/library/genes/891NCBI Gene
CDC78,317PubTator's text mininghttps://conductscience.org/library/genes/8317NCBI Gene
CDK21,017PubTator's text mininghttps://conductscience.org/library/genes/1017NCBI Gene
CDT181,620PubTator's text mininghttps://conductscience.org/library/genes/81620NCBI Gene
CEP19255,125PubTator's text mininghttps://conductscience.org/library/genes/55125NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
E2F11,869PubTator's text mininghttps://conductscience.org/library/genes/1869NCBI Gene
FANCD22,177PubTator's text mininghttps://conductscience.org/library/genes/2177NCBI Gene
FN12,335PubTator's text mininghttps://conductscience.org/library/genes/2335NCBI Gene

1 to 10 of 21

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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