Paper · 20962002

Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine.

Chen M and 13 others. J Physiol, 2010. Cited by 33 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine. Papers, record 20962002. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20962002

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine.; PubMed
Journal: J Physiol; PubMed
Year: 2010; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/20962002/; PubMed
DOI: https://doi.org/10.1113/jphysiol.2010.198721; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3036196/; PubMed
The journal: https://conductscience.org/library/journal-index/0266262; PubMed
Citations, by iCite: 33; iCite
Relative citation ratio, by iCite: 0.88; iCite
Revised in PubMed: 2021-10-20; PubMed

Authors14

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Chen M	Mingmin
2	Sultan A	Ayesha
3	Cinar A	Ayhan
4	Yeruva S	Sunil
5	Riederer B	Brigitte
6	Singh AK	Anurag Kumar
7	Li J	Junhua
8	Bonhagen J	Janina
9	Chen G	Gang
10	Yun C	Chris

1 to 10 of 14Source PubMed

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Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Calcium	Major topic
Cell Membrane	Major topic
Cyclic AMP	Major topic
Cyclic GMP	Major topic
Phosphoproteins	Major topic
Sodium-Hydrogen Exchangers	Major topic
Animals
Gene Expression Regulation
Hydrogen-Ion Concentration
Intestinal Mucosa
Mice
Mice, Knockout
RNA, Messenger
Sodium-Hydrogen Exchanger 3
Water

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R01 DK026523	NIDDK NIH HHS	United States	R01DK026523	PubMed and NIH	NIH RePORTER
R01 DK061418	NIDDK NIH HHS	United States	R01DK061418	PubMed and NIH	NIH RePORTER
R01 DK061765	NIDDK NIH HHS	United States	R01DK061765	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References50

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	16,103,375	Rho GTPases dictate the mobility of the Na/H exchanger NHE3 in epithelia: role in apical retention and targeting.	Proc Natl Acad Sci U S A	2005	https://conductscience.org/library/papers/16103375	PubMed
2	9,096,337	cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.	Proc Natl Acad Sci U S A	1997	https://conductscience.org/library/papers/9096337	PubMed
3	11,950,846	A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.	J Biol Chem	2002	https://conductscience.org/library/papers/11950846	PubMed
4	20,571,054	NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.	J Cell Sci	2010	https://conductscience.org/library/papers/20571054	PubMed
5	19,221,439	Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.	J Clin Invest	2009	https://conductscience.org/library/papers/19221439	PubMed
6	12,595,524	Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism.	J Biol Chem	2003	https://conductscience.org/library/papers/12595524	PubMed
7	9,748,260	NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin.	J Biol Chem	1998	https://conductscience.org/library/papers/9748260	PubMed
8	7,202,010	Organization of actin, myosin, and intermediate filaments in the brush border of intestinal epithelial cells.	J Cell Biol	1982	https://conductscience.org/library/papers/7202010	PubMed
9	19,158,399	Renal NHE3 and NaPi2 partition into distinct membrane domains.	Am J Physiol Cell Physiol	2009	https://conductscience.org/library/papers/19158399	PubMed
10	8,780,725	The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine.	Biochem Biophys Res Commun	1996	https://conductscience.org/library/papers/8780725	PubMed

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Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 33 citations.

PMID	Title	Journal	Year	In Papers	Source
35,665,228	The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity.	Front Physiol	2022	https://conductscience.org/library/papers/35665228	PubMed
33,904,662	The role of NHE3 (Slc9a3) in oxalate and sodium transport by mouse intestine and regulation by cAMP.	Physiol Rep	2021	https://conductscience.org/library/papers/33904662	PubMed
31,760,765	Impairment of electroneutral Na+ transport and associated downregulation of NHE3 contributes to the development of diarrhea following in vivo challenge with Brachyspira spp.	Am J Physiol Gastrointest Liver Physiol	2020	https://conductscience.org/library/papers/31760765	PubMed
31,365,292	NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells.	Am J Physiol Cell Physiol	2019	https://conductscience.org/library/papers/31365292	PubMed
29,967,942	Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis.	J Mol Med (Berl)	2018	https://conductscience.org/library/papers/29967942	PubMed
28,882,822	Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid.	Am J Physiol Gastrointest Liver Physiol	2018	https://conductscience.org/library/papers/28882822	PubMed
28,495,796	Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes.	Mol Biol Cell	2017	https://conductscience.org/library/papers/28495796	PubMed
28,090,568	Pathophysiology of Intestinal Na+/H+ exchange.	Cell Mol Gastroenterol Hepatol	2017	https://conductscience.org/library/papers/28090568	PubMed
26,898,110	Mucosal immunity to pathogenic intestinal bacteria.	Nat Rev Immunol	2016	https://conductscience.org/library/papers/26898110	PubMed
26,122,478	Secretory diarrhoea: mechanisms and emerging therapies.	Nat Rev Gastroenterol Hepatol	2015	https://conductscience.org/library/papers/26122478	PubMed

1 to 10 of 27

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
SLC9A3	6,550	PubTator's text mining	https://conductscience.org/library/genes/6550

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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