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Paper · 210640

The localization of a histamine H2-receptor adenylate cyclase system in canine parietal cells and its inhibition by prostaglandins.

Major JS and 1 other. Agents Actions, 1978. Cited by 80 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The localization of a histamine H2-receptor adenylate cyclase system in canine parietal cells and its inhibition by prostaglandins. Papers, record 210640. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/210640

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The localization of a histamine H2-receptor adenylate cyclase system in canine parietal cells and its inhibition by prostaglandins.
PubMed
Journal
Agents Actions
PubMed
Year
1978
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
80
iCite
Relative citation ratio, by iCite
2.87
iCite
Revised in PubMed
2020-03-04
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Major JSJ S
2Scholes PP

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adenylyl CyclasesMajor topic
Gastric MucosaMajor topic
Prostaglandins EMajor topic
Receptors, HistamineMajor topic
Receptors, Histamine H2Major topic
Adenylyl Cyclase Inhibitors
Animals
Cyclic AMP
Dogs
In Vitro Techniques
Prostaglandins E, Synthetic
Prostaglandins F

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,147,223An improved method for the separation of cells by sedimentation at unit gravity.Anal Biochem1975https://conductscience.org/library/papers/1147223PubMed
24,668,604Proceedings: Effects of prostaglandin E2 on rat gastric mucosal blood flow, as determined by 14C-aniline clearance.Br J Pharmacol1972https://conductscience.org/library/papers/4668604PubMed
346,921The effects of the H1 and H2 antihistamines on "allergic" histamine release and its inhibition by histamine.J Pharmacol Exp Ther1975https://conductscience.org/library/papers/46921PubMed
4180,055Interaction of prostaglandins and histamine with enzymes of cyclic AMP metabolism from guinea pig gastric mucosa.J Clin Invest1976https://conductscience.org/library/papers/180055PubMed
54,391,836Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation.Proc Soc Exp Biol Med1970https://conductscience.org/library/papers/4391836PubMed
64,303,810Inhibition of gastric acid secretion in vitro by prostaglandin E1.Nature1969https://conductscience.org/library/papers/4303810PubMed
74,150,324Metiamide--an orally active histamine H2-receptor antagonist.Agents Actions1973https://conductscience.org/library/papers/4150324PubMed
8177,326Re-evaluation of the role of cyclic AMP in histamine-induced gastric acid secretion.Gastroenterology1976https://conductscience.org/library/papers/177326PubMed
93,419Action of H1 and H2 inhibitors on the response of histamine sensitive adenyly cyclase from guinea-pig mucosa.Eur J Clin Invest1976https://conductscience.org/library/papers/3419PubMed
104,341,924Adenosine 3',5'-,monophosphate (cyclic AMP) and secretion in the canine stomach.Gastroenterology1972https://conductscience.org/library/papers/4341924PubMed

1 to 10 of 24

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Cited by18

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 80 citations.

PMIDTitleJournalYearIn PapersSource
31,670,611The Physiology of the Gastric Parietal Cell.Physiol Rev2020https://conductscience.org/library/papers/31670611PubMed
7,859,583Pharmacological aspects of acid secretion.Dig Dis Sci1995https://conductscience.org/library/papers/7859583PubMed
7,389,526Inhibition of histamine-sensitive adenylate cyclase from guinea pig fundic gastric mucosa by arachidonic acid and by an analog of prostaglandin endoperoxide PGH2.Dig Dis Sci1980https://conductscience.org/library/papers/7389526PubMed
6,260,277The gastric antisecretory actions of prostaglandin E2 and stable prostacyclin analogues against different secretagogues in perfused whole-stomachs of rat or mouse in vitro.Br J Pharmacol1981https://conductscience.org/library/papers/6260277PubMed
6,154,063Specific inhibition by prostaglandins E2 and I2 of histamine-stimulated [14C]aminopyrine accumulation and cyclic adenosine monophosphate generation by isolated canine parietal cells.J Clin Invest1980https://conductscience.org/library/papers/6154063PubMed
6,135,324Comparison of the effect of PGE2 and somatostatin on histamine stimulated 14C-aminopyrine uptake and cyclic AMP formation in isolated rat gastric mucosal cells.Agents Actions1983https://conductscience.org/library/papers/6135324PubMed
6,123,240Histamine-sensitive adenylate cyclase in human gastric mucosa: cellular localization and interaction by PGE2, somatostatin and secretin.Agents Actions1982https://conductscience.org/library/papers/6123240PubMed
3,932,048Misoprostol, a synthetic PGE1 analog, in the treatment of duodenal ulcers. A multicenter double-blind study.Dig Dis Sci1985https://conductscience.org/library/papers/3932048PubMed
3,924,152Prostaglandin formation by isolated gastric parietal and nonparietal cells of the rat.Br J Pharmacol1985https://conductscience.org/library/papers/3924152PubMed
3,314,155Recent advances in the treatment of duodenal ulcer disease. A surgical perspective.West J Med1987https://conductscience.org/library/papers/3314155PubMed

1 to 10 of 18

See all 18 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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