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Paper · 3932048

Misoprostol, a synthetic PGE1 analog, in the treatment of duodenal ulcers. A multicenter double-blind study.

Brand DL and 3 others. Dig Dis Sci, 1985. Cited by 89 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Misoprostol, a synthetic PGE1 analog, in the treatment of duodenal ulcers. A multicenter double-blind study. Papers, record 3932048. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3932048

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Misoprostol, a synthetic PGE1 analog, in the treatment of duodenal ulcers. A multicenter double-blind study.
PubMed
Journal
Dig Dis Sci
PubMed
Year
1985
PubMed
Publication types
Clinical Trial, Journal Article, Randomized Controlled Trial
PubMed
Citations, by iCite
89
iCite
Relative citation ratio, by iCite
5.88
iCite
Revised in PubMed
2026-10-11
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Brand DLD L
2Roufail WMW M
3Thomson ABA B
4Tapper EJE J

Source PubMed

Topics23

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AlprostadilMajor topic
Anti-Ulcer AgentsMajor topic
Duodenal UlcerMajor topic
Adolescent
Adult
Aged
Alcohol Drinking
Antacids
Clinical Trials as Topic
Diarrhea
Dose-Response Relationship, Drug
Double-Blind Method
Drug Interactions
Duodenoscopy
Female
Gastric Mucosa
Humans
Male
Middle Aged
Misoprostol
Pain
Random Allocation
Smoking

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References46

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1458,634Effects of a prostaglandin E1 derivative, SC-29333, and aspirin on gastric ionic fluxes and potential difference in dogs.J Pharmacol Exp Ther1979https://conductscience.org/library/papers/458634PubMed
26,816,064Inhibition of nocturnal gastric secretion in normal human volunteers by misoprostol: a synthetic prostaglandin E1 methyl ester analog.Am J Gastroenterol1982https://conductscience.org/library/papers/6816064PubMed
3210,640The localization of a histamine H2-receptor adenylate cyclase system in canine parietal cells and its inhibition by prostaglandins.Agents Actions1978https://conductscience.org/library/papers/210640PubMed
44,325,309Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins.J Clin Invest1971https://conductscience.org/library/papers/4325309PubMed
57,320,463Statistical considerations in drug trials of peptic ulcer.J Clin Gastroenterol1981https://conductscience.org/library/papers/7320463PubMed
61,158,077Effects of an orally administered prostaglandin analogue (16, 16-dimethyl prostaglandin E2) on human gastric secretion.Gastroenterology1975https://conductscience.org/library/papers/1158077PubMed
77,351,286Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic diseases.Gastroenterology1980https://conductscience.org/library/papers/7351286PubMed
86,114,771Women and duodenal ulcer.Br Med J (Clin Res Ed)1981https://conductscience.org/library/papers/6114771PubMed
9797,257SC-29333: a potent inhibitor of canin gastric secretion.Am J Dig Dis1976https://conductscience.org/library/papers/797257PubMed
104,359,941Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.J Clin Invest1974https://conductscience.org/library/papers/4359941PubMed

1 to 10 of 46

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Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 89 citations.

PMIDTitleJournalYearIn PapersSource
33,322,104In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug.Molecules2020https://conductscience.org/library/papers/33322104PubMed
23,839,876Inhibitory effect of prostaglandin E1 on gastric secretion during general anesthesia in humans.J Anesth1995https://conductscience.org/library/papers/23839876PubMed
8,574,332A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease.J Gastroenterol1995https://conductscience.org/library/papers/8574332PubMed
7,766,337A comparative overview of the adverse effects of antiulcer drugs.Drug Saf1995https://conductscience.org/library/papers/7766337PubMed
3,932,053Overview of clinical safety with misoprostol.Dig Dis Sci1985https://conductscience.org/library/papers/3932053PubMed
3,792,228Prostaglandins in peptic ulcer disease. An overview of current status and future directions.Drugs1986https://conductscience.org/library/papers/3792228PubMed
3,139,379Double-blind comparison of two dosage regimens of misoprostol in the treatment of duodenal ulceration.Dig Dis Sci1988https://conductscience.org/library/papers/3139379PubMed
3,125,025Evaluation of antisecretory activity of misoprostol in duodenal ulcer patients using long-term intragastric pH monitoring.Dig Dis Sci1988https://conductscience.org/library/papers/3125025PubMed
3,102,205Misoprostol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of peptic ulcer disease.Drugs1987https://conductscience.org/library/papers/3102205PubMed
3,080,291Efficacy of misoprostol (twice daily dosage) in acute healing of duodenal ulcer. A multicenter double-blind controlled trial.Dig Dis Sci1986https://conductscience.org/library/papers/3080291PubMed

1 to 10 of 14

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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