Paper · 4359941

Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.

Kimberg DV and 3 others. J Clin Invest, 1974. Cited by 150 papers, by iCite.

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ConductScience Library. Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin. Papers, record 4359941. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4359941

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.; PubMed
Journal: J Clin Invest; PubMed
Year: 1974; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4359941/; PubMed
DOI: https://doi.org/10.1172/jci107635; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC333077/; PubMed
The journal: https://conductscience.org/library/journal-index/7802877; PubMed
Citations, by iCite: 150; iCite
Relative citation ratio, by iCite: 6.12; iCite
Revised in PubMed: 2018-11-13; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kimberg DV	D V
2	Field M	M
3	Gershon E	E
4	Henderson A	A

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cyclic AMP	Major topic
Enterotoxins	Major topic
Intestinal Mucosa	Major topic
Prostaglandins	Major topic
Adenylyl Cyclases
Animals
Aspirin
Cholera
Drug Synergism
Enzyme Activation
Ileum
In Vitro Techniques
Indomethacin
Intestinal Secretions
Rabbits
Theophylline
Time Factors
Vibrio cholerae

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	5,645,863	Site and characteristics of electrolyte loss and effect of intraluminal glucose in experimental canine cholera.	J Clin Invest	1968	https://conductscience.org/library/papers/5645863	PubMed
2	5,776,009	The relationship of superior mesenteric artery blood flow to gut electrolyte loss in experimental cholera.	J Infect Dis	1969	https://conductscience.org/library/papers/5776009	PubMed
3	5,409,804	Intestinal fluid and electrolyte transport in human cholera.	J Clin Invest	1970	https://conductscience.org/library/papers/5409804	PubMed
4	5,416,693	Small bowel morphology in experimental canine cholera. A light and electron microscopic study.	Lab Invest	1970	https://conductscience.org/library/papers/5416693	PubMed
5	5,417,183	Formation of [I-14C] prostaglandin E2 and two prostaglandin metabolites from [I-14C] arachidonic acid during vascular perfusion of the frog intestine.	Biochim Biophys Acta	1970	https://conductscience.org/library/papers/5417183	PubMed
6	4,317,401	Prostaglandin receptor site: evidence for an essential role in the action of luteinizing hormone.	Science	1970	https://conductscience.org/library/papers/4317401	PubMed
7	4,318,781	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	Proc Natl Acad Sci U S A	1970	https://conductscience.org/library/papers/4318781	PubMed
8	4,321,839	Cholera enterotoxin--recent investigations yield insights into transport processes.	Am J Med	1971	https://conductscience.org/library/papers/4321839	PubMed
9	5,544,090	Effects of prostaglandins, theophylline, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum.	Gastroenterology	1971	https://conductscience.org/library/papers/5544090	PubMed
10	4,323,551	Stimulation of intestinal adenyl cyclase by cholera toxin.	Nature	1971	https://conductscience.org/library/papers/4323551	PubMed

1 to 10 of 33

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Cited by47

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 150 citations.

PMID	Title	Journal	Year	In Papers	Source
29,470,490	Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera.	PLoS Negl Trop Dis	2018	https://conductscience.org/library/papers/29470490	PubMed
12,797,547	The cox-2-specific inhibitor celecoxib inhibits adenylyl cyclase.	Inflammation	2003	https://conductscience.org/library/papers/12797547	PubMed
9,109,445	Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin.	J Clin Invest	1997	https://conductscience.org/library/papers/9109445	PubMed
7,508,124	CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.	Proc Natl Acad Sci U S A	1994	https://conductscience.org/library/papers/7508124	PubMed
7,204,555	Physiologic and pharmacologic effects of glucocorticoids on ion transport across rabbit ileal mucosa in vitro.	J Clin Invest	1981	https://conductscience.org/library/papers/7204555	PubMed
7,066,606	Kinins stimulate net chloride secretion by the rat colon.	Br J Pharmacol	1982	https://conductscience.org/library/papers/7066606	PubMed
6,699,901	Electrical activity of an intestinal epithelial cell line: hyperpolarizing responses to intestinal secretagogues.	J Membr Biol	1984	https://conductscience.org/library/papers/6699901	PubMed
6,363,286	Purified Shigella enterotoxin does not alter intestinal motility.	Infect Immun	1984	https://conductscience.org/library/papers/6363286	PubMed
6,331,558	Role of calcium ions in kinin-induced chloride secretion.	Br J Pharmacol	1984	https://conductscience.org/library/papers/6331558	PubMed
6,301,596	Inhibition by morphine of prostaglandin E1-stimulated secretion and cyclic adenosine 3',5'-monophosphate formation in the rat jejunum in vivo.	Br J Pharmacol	1980	https://conductscience.org/library/papers/6301596	PubMed

1 to 10 of 47

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ADCY1	107	PubTator's text mining	https://conductscience.org/library/genes/107	NCBI Gene
PDE3B	5,140	PubTator's text mining	https://conductscience.org/library/genes/5140	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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