ConductScience.org, home

Gene · 5140

PDE3B: phosphodiesterase 3B

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. PDE3B: phosphodiesterase 3B. Genes, record 5140. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5140

On this page

Gene

Symbol
PDE3B
HGNC
Name
phosphodiesterase 3B
HGNC
NCBI Gene ID
5140
NCBI Gene
HGNC ID
HGNC:8779
HGNC
Ensembl
ENSG00000152270
NCBI Gene
Aliases
HcGIP1, cGIPDE1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13370cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B1,1124Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457705Q13370Espacenet
EP 4641201 A22025-10-292705Q13370Espacenet
EP 4641202 A22025-10-29159Q13370Espacenet
JP 2025529142 A2025-09-043428Q13370Espacenet
US 12371689 B22025-07-293428Q13370Espacenet
JP 2025517969 A2025-06-122705Q13370Espacenet
JP 2025032204 A2025-03-1133154Q13370Espacenet
KR 1020250017231 A2025-02-04159Q13370Espacenet
JP 2025004127 A2025-01-148Q13370Espacenet
EP 4461818 A22024-11-1333154Q13370Espacenet

1 to 10 of 51

See all 51 patents

Drugs14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMINOPHYLLINECHEMBL1370561Phosphodiesterase 3 inhibitorINHIBITORChEMBL
ANAGRELIDECHEMBL760Phosphodiesterase 3 inhibitorINHIBITORChEMBL
ANAGRELIDE HYDROCHLORIDECHEMBL1200759Phosphodiesterase 3 inhibitorINHIBITORChEMBL
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
ENOXIMONECHEMBL249856Phosphodiesterase 3 inhibitorINHIBITORChEMBL
ENSIFENTRINECHEMBL4594287Phosphodiesterase 3 inhibitorINHIBITORChEMBL
K-134CHEMBL284838Phosphodiesterase 3 inhibitorINHIBITORChEMBL
LEVOSIMENDANCHEMBL2051955Phosphodiesterase 3 inhibitorINHIBITORChEMBL
OXTRIPHYLLINECHEMBL1200434Phosphodiesterase 3 inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

1 to 10 of 14

See all 14 drugs

Trials255

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07436689LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07348510AMINOPHYLLINEClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07288398LEVOSIMENDANPHASE3ClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07186062LEVOSIMENDANClinicalTrials.gov
NCT07132983ENSIFENTRINEPHASE2ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov

1 to 10 of 255

See all 255 trials

NIH grants1,172

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE3B papersNewest fiscal year
P30CA008748Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)52025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
P30DK017047Diabetes Research Center32025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)32025
R01AG059779Combining GHR antagonism with life extending compounds: a search for synergies32025
R01GM079465Chemical Probes to Study Copper Biology32025
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease22025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center22025
P30CA013148Comprehensive Cancer Center Support Grant22025

1 to 10 of 1,172Source NIH's project files

See all 1,172 nih grants

Papers1,572

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The PDE3-specific inhibitor milrinone improves asthenozoospermic sperm function by regulating cAMP-PKA signaling pathway and energy metabolism.Reprod Fertil Dev202642692814PubTator, text miningPubMed
Retraction notice to "Hsa_circ_0007707 participates in PDE3B-mediated apoptosis inhibition and inflammation promotion in fibroblast-like synoviocytes" [Int. Immunopharmacol. 119 (2023) 110157].Int Immunopharmacol202642595645PubTator, text miningPubMed
Integrative exome sequencing and multi-omics analysis elucidates the regulatory role of rare variants in metabolic syndrome.Funct Integr Genomics202642472903PubTator, text miningPubMed
Evaluating the prognostic value of cuproptosis-related genes and characterizing PDE3B's role in gastric cancer: integrative bioinformatics analysis and experimental validation.J Gastrointest Oncol202642434223PubTator, text miningPubMed
A Liver-Targeted Copper Supplement Reduces Metabolic Dysfunction-Associated Liver Steatosis by Increasing Lipolysis and Fatty Acid Oxidation.bioRxiv202642239390PubTator, text miningPubMed
Single-cell RNA-sequencing reveals cellular heterogeneity and identifies biomarkers for obstructive sleep apnea and migraine.Hum Genomics202642116076PubTator, text miningPubMed
Machine learning-driven transcriptomic and single-cell profiling of programed cell death patterns in colon cancer.Sci Prog202641854308PubTator, text miningPubMed
Current understanding and advances regarding the adipose-immune-metabolic axis in disease tolerance during sepsis.Front Immunol202641853269PubTator, text miningPubMed
cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights.Front Endocrinol (Lausanne)202641816209PubTator, text miningPubMed
Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review.Medicine (Baltimore)202641790675PubTator, text miningPubMed

1 to 10 of 1,572

See all 1,572 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5140

GET https://conductscience.org/api/genes/v1/5140/patents?page=2