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Paper21152002

Axial and radial forces of cross-bridges depend on lattice spacing.

Williams CD and 2 others. PLoS Comput Biol, 2010. Cited by 55 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Axial and radial forces of cross-bridges depend on lattice spacing. Papers, record 21152002. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21152002

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Axial and radial forces of cross-bridges depend on lattice spacing.
PubMed
Journal
PLoS Comput Biol
PubMed
Year
2010
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
55
iCite
Relative citation ratio, by iCite
1.6
iCite
Revised in PubMed
2021-10-20
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Williams CDC David
2Regnier MMichael
3Daniel TLThomas L

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Biomechanical PhenomenaMajor topic
Computational BiologyMajor topic
Molecular Dynamics SimulationMajor topic
MyosinsMajor topic
Protein Structure, QuaternaryMajor topic
Actins
Adenosine Diphosphate
Adenosine Triphosphate
Models, Biological
Protein Binding
Sarcomeres
Torque

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 HL065497NHLBI NIH HHSUnited StatesR01HL065497PubMed and NIHNIH RePORTER
T32 EB001650NIBIB NIH HHSUnited StatesT32EB001650PubMed and NIHNIH RePORTER
R01 HL65497-05-09NHLBI NIH HHSUnited StatesR01HL654970PubMedNIH RePORTER

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
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23,496,924Measurement of sarcomere shortening in skinned fibers from frog muscle by white light diffraction.Biophys J1987https://conductscience.org/library/papers/3496924PubMed
310,571,184Tomographic 3D reconstruction of quick-frozen, Ca2+-activated contracting insect flight muscle.Cell1999https://conductscience.org/library/papers/10571184PubMed
46,608,003Changes in the lateral filament spacing of skinned muscle fibres when cross-bridges attach.J Mol Biol1984https://conductscience.org/library/papers/6608003PubMed
5314,510The velocity of unloaded shortening and its relation to sarcomere length and isometric force in vertebrate muscle fibres.J Physiol1979https://conductscience.org/library/papers/314510PubMed
614,747,335Response of equatorial x-ray reflections and stiffness to altered sarcomere length and myofilament lattice spacing in relaxed skinned cardiac muscle.Biophys J2004https://conductscience.org/library/papers/14747335PubMed
77,858,133Lattice spacing changes accompanying isometric tension development in intact single muscle fibers.Biophys J1994https://conductscience.org/library/papers/7858133PubMed
811,017,871Visualizing myosin's power stroke in muscle contraction.J Cell Sci2000https://conductscience.org/library/papers/11017871PubMed
915,636,115A spatially explicit nanomechanical model of the half-sarcomere: myofilament compliance affects Ca(2+)-activation.Ann Biomed Eng2004https://conductscience.org/library/papers/15636115PubMed
1011,904,418Mutation of the myosin converter domain alters cross-bridge elasticity.Proc Natl Acad Sci U S A2002https://conductscience.org/library/papers/11904418PubMed
112,255,911Detection of radial crossbridge force by lattice spacing changes in intact single muscle fibers.Science1990https://conductscience.org/library/papers/2255911PubMed
1215,117,248Single-molecule fluorescence spectroscopy and microscopy of biomolecular motors.Annu Rev Phys Chem2004https://conductscience.org/library/papers/15117248PubMed
136,970,793Radial forces within muscle fibers in rigor.J Gen Physiol1981https://conductscience.org/library/papers/6970793PubMed
148,316,857Three-dimensional structure of myosin subfragment-1: a molecular motor.Science1993https://conductscience.org/library/papers/8316857PubMed
1516,205,841Length-dependent Ca(2+) activation in cardiac muscle: some remaining questions.J Muscle Res Cell Motil2005https://conductscience.org/library/papers/16205841PubMed
166,894,872Geometrical factors influencing muscle force development. I. The effect of filament spacing upon axial forces.Biophys J1980https://conductscience.org/library/papers/6894872PubMed
179,545,027Compliant realignment of binding sites in muscle: transient behavior and mechanical tuning.Biophys J1998https://conductscience.org/library/papers/9545027PubMed
196,894,873Geometrical factors influencing muscle force development. II. Radial forces.Biophys J1980https://conductscience.org/library/papers/6894873PubMed
2011,297,926Myosin motors: missing structures and hidden springs.Curr Opin Struct Biol2001https://conductscience.org/library/papers/11297926PubMed
2111,016,966Three conformational states of scallop myosin S1.Proc Natl Acad Sci U S A2000https://conductscience.org/library/papers/11016966PubMed

See all 37 references

Cited by40

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 55 citations.

PMIDTitleJournalYearIn PapersSource
42,395,535The E525K β-Myosin Mutation Causes Hypocontractility in Cardiomyocytes Without Altering Loaded Crossbridge Cycling.bioRxiv2026https://conductscience.org/library/papers/42395535PubMed
42,166,798Force-Induced Ankle Opening Reveals Mechanical Stabilization of the Ankle of Human β-Cardiac Myosin.ACS Nano2026https://conductscience.org/library/papers/42166798PubMed
40,734,276Biaxial length-tension relationship in single cardiac myocytes.Biophys J2025https://conductscience.org/library/papers/40734276PubMed
40,520,106β-adrenergic signaling modulates breast cancer cell mechanical behaviors through a RhoA-ROCK-myosin II axis.iScience2025https://conductscience.org/library/papers/40520106PubMed
40,193,853Nanometer scale difference in myofilament lattice structure of muscle alters muscle function in a spatially explicit model.PLoS Comput Biol2025https://conductscience.org/library/papers/40193853PubMed
39,604,261Bayesian estimation of muscle mechanisms and therapeutic targets using variational autoencoders.Biophys J2025https://conductscience.org/library/papers/39604261PubMed
39,543,073The Relationship Between Length and Active Force for Submaximal Skeletal Muscle Contractions: a Review.Sports Med2025https://conductscience.org/library/papers/39543073PubMed
39,283,968The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca2+].J Physiol2024https://conductscience.org/library/papers/39283968PubMed
39,278,223In defense of Huxley.Biophys J2024https://conductscience.org/library/papers/39278223PubMed
38,567,164An In Silico Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy.Biomed Res Int2024https://conductscience.org/library/papers/38567164PubMed
38,038,843Design Principles and Benefits of Spatially Explicit Models of Myofilament Function.Methods Mol Biol2024https://conductscience.org/library/papers/38038843PubMed
37,000,171Machine learning meets Monte Carlo methods for models of muscle's molecular machinery to classify mutations.J Gen Physiol2023https://conductscience.org/library/papers/37000171PubMed
36,229,433Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles.Nat Commun2022https://conductscience.org/library/papers/36229433PubMed
35,771,335The effect of muscle length on post-tetanic potentiation of C57BL/6 and skMLCK-/- mouse EDL muscles.J Muscle Res Cell Motil2022https://conductscience.org/library/papers/35771335PubMed
35,450,825Muscle active force-length curve explained by an electrophysical model of interfilament spacing.Biophys J2022https://conductscience.org/library/papers/35450825PubMed
35,328,477Small Angle X-ray Diffraction as a Tool for Structural Characterization of Muscle Disease.Int J Mol Sci2022https://conductscience.org/library/papers/35328477PubMed
35,055,055Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy.Int J Mol Sci2022https://conductscience.org/library/papers/35055055PubMed
34,384,761A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice.Biophys J2021https://conductscience.org/library/papers/34384761PubMed
34,117,120Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.Proc Natl Acad Sci U S A2021https://conductscience.org/library/papers/34117120PubMed
33,281,608The Energy of Muscle Contraction. II. Transverse Compression and Work.Front Physiol2020https://conductscience.org/library/papers/33281608PubMed

See all 40 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
MYH1479,784PubTator's text mininghttps://conductscience.org/library/genes/79784

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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