Paper39604261

Bayesian estimation of muscle mechanisms and therapeutic targets using variational autoencoders.

Tune T and 4 others. Biophys J, 2025. Cited by 1 paper, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Bayesian estimation of muscle mechanisms and therapeutic targets using variational autoencoders. Papers, record 39604261. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39604261

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Bayesian estimation of muscle mechanisms and therapeutic targets using variational autoencoders.; PubMed
Journal: Biophys J; PubMed
Year: 2025; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/39604261/; PubMed
DOI: https://doi.org/10.1016/j.bpj.2024.11.3310; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC11739888/; PubMed
The journal: https://conductscience.org/library/journal-index/0370626; PubMed
Citations, by iCite: 1; iCite
Revised in PubMed: 2026-03-07; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Tune T	Travis
2	Kooiker KB	Kristina B
3	Davis J	Jennifer
4	Daniel T	Thomas
5	Moussavi-Harami F	Farid

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Bayes Theorem	Major topic
Animals
Mice
Sarcomeres
Models, Biological
Troponin C
Cardiomyopathies
Mutation

Source PubMed

Show 2 more topicsShow fewer topics

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
P30 AR074990	NIAMS NIH HHS	United States	P30AR074990	PubMed and NIH	NIH RePORTER
R01 HL141187	NHLBI NIH HHS	United States	R01HL141187	PubMed and NIH	NIH RePORTER
R01 HL142624	NHLBI NIH HHS	United States	R01HL142624	PubMed and NIH	NIH RePORTER
R01 HL157169	NHLBI NIH HHS	United States	R01HL157169	PubMed and NIH	NIH RePORTER

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers
Update of	38,766,103

Source PubMed

References41

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	27,114,035	A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.	Cell	2016	https://conductscience.org/library/papers/27114035	PubMed
2	21,152,002	Axial and radial forces of cross-bridges depend on lattice spacing.	PLoS Comput Biol	2010	https://conductscience.org/library/papers/21152002	PubMed
3	28,509,977	The role of super-relaxed myosin in skeletal and cardiac muscle.	Biophys Rev	2015	https://conductscience.org/library/papers/28509977	PubMed
4	19,966,283	Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers.	Proc Natl Acad Sci U S A	2010	https://conductscience.org/library/papers/19966283	PubMed
5	34,932,957	FiberSim: A flexible open-source model of myofilament-level contraction.	Biophys J	2022	https://conductscience.org/library/papers/34932957	PubMed
6	33,636,222	The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions.	J Mol Cell Cardiol	2021	https://conductscience.org/library/papers/33636222	PubMed
7	30,732,532	Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations.	Circ Res	2019	https://conductscience.org/library/papers/30732532	PubMed
8	21,980,268	A mathematical model of muscle containing heterogeneous half-sarcomeres exhibits residual force enhancement.	PLoS Comput Biol	2011	https://conductscience.org/library/papers/21980268	PubMed
9	33,303,684	Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.	Science	2021	https://conductscience.org/library/papers/33303684	PubMed
10	28,379,779	A Procedure for Deriving Formulas to Convert Transition Rates to Probabilities for Multistate Markov Models.	Med Decis Making	2017	https://conductscience.org/library/papers/28379779	PubMed
11	2,527,246	A model of crossbridge action: the effects of ATP, ADP and Pi.	J Muscle Res Cell Motil	1989	https://conductscience.org/library/papers/2527246	PubMed
12	23,454,346	Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variants.	Arch Biochem Biophys	2013	https://conductscience.org/library/papers/23454346	PubMed
13	22,995,500	Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscle.	Biophys J	2012	https://conductscience.org/library/papers/22995500	PubMed
14	9,562,033	The filament lattice of striated muscle.	Physiol Rev	1998	https://conductscience.org/library/papers/9562033	PubMed
15	29,873,724	Can Strain Dependent Inhibition of Cross-Bridge Binding Explain Shifts in Optimum Muscle Length?	Integr Comp Biol	2018	https://conductscience.org/library/papers/29873724	PubMed
16	11,390,828	An Integrated View of Insect Flight Muscle: Genes, Motor Molecules, and Motion.	News Physiol Sci	1999	https://conductscience.org/library/papers/11390828	PubMed
17	33,635,868	Generating functional protein variants with variational autoencoders.	PLoS Comput Biol	2021	https://conductscience.org/library/papers/33635868	PubMed
18	29,897,447	A Spatially Explicit Model Shows How Titin Stiffness Modulates Muscle Mechanics and Energetics.	Integr Comp Biol	2018	https://conductscience.org/library/papers/29897447	PubMed
19	9,545,027	Compliant realignment of binding sites in muscle: transient behavior and mechanical tuning.	Biophys J	1998	https://conductscience.org/library/papers/9545027	PubMed
20	6,971,874	Sinusoidal analysis: a high resolution method for correlating biochemical reactions with physiological processes in activated skeletal muscles of rabbit, frog and crayfish.	J Muscle Res Cell Motil	1980	https://conductscience.org/library/papers/6971874	PubMed

Show 14 more referencesShow fewer referencesSee all 41 references

Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1 citation.

PMID	Title	Journal	Year	In Papers
42,395,535	The E525K β-Myosin Mutation Causes Hypocontractility in Cardiomyocytes Without Altering Loaded Crossbridge Cycling.	bioRxiv	2026	https://conductscience.org/library/papers/42395535

Source PubMed

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Trials
Genes
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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