Paper · 2124253

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

Weiss U and 1 other. J Exp Med, 1990. Cited by 188 papers, by iCite.

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ConductScience Library. The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response. Papers, record 2124253. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2124253

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.; PubMed
Journal: J Exp Med; PubMed
Year: 1990; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2124253/; PubMed
DOI: https://doi.org/10.1084/jem.172.6.1681; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2188767/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 188; iCite
Relative citation ratio, by iCite: 3.06; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Weiss U	U
2	Rajewsky K	K

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
B-Lymphocytes	Major topic
Gene Rearrangement	Major topic
Genes, Immunoglobulin	Major topic
Immunoglobulin Variable Region	Major topic
Immunologic Memory	Major topic
Mutation	Major topic
Nitrophenols	Major topic
Amino Acid Sequence
Animals
Base Sequence
Female
Haptens
Immunization
Immunoglobulin lambda-Chains
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Phenylacetates
Spleen

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,203,114	Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.	Proc Natl Acad Sci U S A	1984	https://conductscience.org/library/papers/6203114	PubMed
2	6,194,407	Plasmid screening at high colony density.	Methods Enzymol	1983	https://conductscience.org/library/papers/6194407	PubMed
3	3,933,987	VH-gene expression in murine lipopolysaccharide blasts distributes over the nine known VH-gene groups and may be random.	Eur J Immunol	1985	https://conductscience.org/library/papers/3933987	PubMed
4	3,017,703	Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain.	EMBO J	1986	https://conductscience.org/library/papers/3017703	PubMed
5	2,430,792	Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP.	EMBO J	1986	https://conductscience.org/library/papers/2430792	PubMed
6	3,493,076	Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses.	Cell	1987	https://conductscience.org/library/papers/3493076	PubMed
7	3,493,491	Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells.	Proc Natl Acad Sci U S A	1987	https://conductscience.org/library/papers/3493491	PubMed
8	3,108,398	Mitogen-driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes.	J Immunol	1987	https://conductscience.org/library/papers/3108398	PubMed
9	3,298,007	Mutation drift and repertoire shift in the maturation of the immune response.	Immunol Rev	1987	https://conductscience.org/library/papers/3298007	PubMed
10	3,298,009	Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development.	Immunol Rev	1987	https://conductscience.org/library/papers/3298009	PubMed

1 to 10 of 35

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Cited by68

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 188 citations.

PMID	Title	Journal	Year	In Papers	Source
42,030,149	Monoclonal antibodies against nitrated nerve growth factor reveal an oxidation-dependent pathogenic hallmark in ALS.	Proc Natl Acad Sci U S A	2026	https://conductscience.org/library/papers/42030149	PubMed
37,750,461	Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine.	Adv Sci (Weinh)	2023	https://conductscience.org/library/papers/37750461	PubMed
36,713,383	CK2β-regulated signaling controls B cell differentiation and function.	Front Immunol	2022	https://conductscience.org/library/papers/36713383	PubMed
32,304,215	Hide and seek: interplay between influenza viruses and B cells.	Int Immunol	2020	https://conductscience.org/library/papers/32304215	PubMed
29,944,756	Germinal center responses to complex antigens.	Immunol Rev	2018	https://conductscience.org/library/papers/29944756	PubMed
29,709,214	Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory.	Elife	2018	https://conductscience.org/library/papers/29709214	PubMed
28,738,289	Germinal center enhancement by extended antigen availability.	Curr Opin Immunol	2017	https://conductscience.org/library/papers/28738289	PubMed
27,513,338	A Public Database of Memory and Naive B-Cell Receptor Sequences.	PLoS One	2016	https://conductscience.org/library/papers/27513338	PubMed
26,948,373	Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.	Immunity	2016	https://conductscience.org/library/papers/26948373	PubMed
26,864,101	Regulation of germinal center B-cell differentiation.	Immunol Rev	2016	https://conductscience.org/library/papers/26864101	PubMed

1 to 10 of 68

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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