Paper · 2186255

Obesity and insulin resistance in humans: a dose-response study.

Bonadonna RC and 5 others. Metabolism, 1990. Cited by 303 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Obesity and insulin resistance in humans: a dose-response study. Papers, record 2186255. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2186255

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Obesity and insulin resistance in humans: a dose-response study.; PubMed
Journal: Metabolism; PubMed
Year: 1990; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2186255/; PubMed
DOI: https://doi.org/10.1016/0026-0495(90)90002-t; PubMed
The journal: https://conductscience.org/library/journal-index/0375267; PubMed
Citations, by iCite: 303; iCite
Relative citation ratio, by iCite: 9.15; iCite
Revised in PubMed: 2022-04-08; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Bonadonna RC	R C
2	Groop L	L
3	Kraemer N	N
4	Ferrannini E	E
5	Del Prato S	S
6	DeFronzo RA	R A

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Insulin Resistance	Major topic
Obesity	Major topic
Adult
Blood Glucose
Dose-Response Relationship, Drug
Female
Glucose
Glucose Clamp Technique
Humans
Insulin
Insulin Secretion
Liver
Male

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
AM24096	NIADDK NIH HHS	United States		PubMed
RR125	NCRR NIH HHS	United States		PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by84

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 303 citations.

PMID	Title	Journal	Year	In Papers	Source
42,231,340	Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults.	J Transl Med	2026	https://conductscience.org/library/papers/42231340	PubMed
41,413,296	Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms.	Diabetologia	2026	https://conductscience.org/library/papers/41413296	PubMed
38,850,502	Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies.	Curr Obes Rep	2024	https://conductscience.org/library/papers/38850502	PubMed
38,711,675	Effect of Maternal Pre-Pregnancy Body Mass Index on Longitudinal Fetal Growth and Mediating Role of Maternal Fasting Plasma Glucose: A Retrospective Cohort Study.	Diabetes Metab Syndr Obes	2024	https://conductscience.org/library/papers/38711675	PubMed
38,609,167	Substituting Carbohydrate at Lunch for Added Protein Increases Fat Oxidation During Subsequent Exercise in Healthy Males.	J Clin Endocrinol Metab	2025	https://conductscience.org/library/papers/38609167	PubMed
38,347,465	Influence of metabolic state and body composition on the action of pharmacological treatment of migraine.	J Headache Pain	2024	https://conductscience.org/library/papers/38347465	PubMed
38,243,954	Gut Microbiota and Insulin Resistance: Understanding the Mechanism of Better Treatment of Type 2 Diabetes Mellitus.	Curr Diabetes Rev	2024	https://conductscience.org/library/papers/38243954	PubMed
36,909,323	Visceral fat correlates with insulin secretion and sensitivity independent of BMI and subcutaneous fat in Chinese with type 2 diabetes.	Front Endocrinol (Lausanne)	2023	https://conductscience.org/library/papers/36909323	PubMed
36,465,102	Bistable insulin response: The win-win solution for glycemic control.	iScience	2022	https://conductscience.org/library/papers/36465102	PubMed
36,112,590	Comparing acute effects of extra virgin coconut oil and extra virgin olive oil consumption on appetite and food intake in normal-weight and obese male subjects.	PLoS One	2022	https://conductscience.org/library/papers/36112590	PubMed

1 to 10 of 84

See all 84 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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