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Paper · 22484809

Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides.

Siewert K and 5 others. Nat Med, 2012. Cited by 56 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides. Papers, record 22484809. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/22484809

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides.
PubMed
Journal
Nat Med
PubMed
Year
2012
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
56
iCite
Relative citation ratio, by iCite
1.27
iCite
Revised in PubMed
2021-10-21
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Siewert KKatherina
2Malotka JJoachim
3Kawakami NNaoto
4Wekerle HHartmut
5Hohlfeld RReinhard
6Dornmair KKlaus

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CD8-Positive T-LymphocytesMajor topic
Combinatorial Chemistry TechniquesMajor topic
Histocompatibility Antigens Class IMajor topic
Peptide LibraryMajor topic
Animals
Antigen-Presenting Cells
COS Cells
Chlorocebus aethiops
Receptors, Antigen, T-Cell

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
12,524,380T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.EMBO J1989https://conductscience.org/library/papers/2524380PubMed
221,436,444Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.Science2011https://conductscience.org/library/papers/21436444PubMed
319,302,040The inflammasomes: guardians of the body.Annu Rev Immunol2009https://conductscience.org/library/papers/19302040PubMed
417,558,425The contribution of immunology to the rational design of novel antibacterial vaccines.Nat Rev Microbiol2007https://conductscience.org/library/papers/17558425PubMed
518,301,425The molecular basis for public T-cell responses?Nat Rev Immunol2008https://conductscience.org/library/papers/18301425PubMed
619,743,458Pathogenic CD8(+) T cells in multiple sclerosis.Ann Neurol2009https://conductscience.org/library/papers/19743458PubMed
716,551,247Human T cell responses against melanoma.Annu Rev Immunol2006https://conductscience.org/library/papers/16551247PubMed
811,479,631Lethality-based selection of recombinant genes in mammalian cells: application to identifying tumor antigens.Nat Med2001https://conductscience.org/library/papers/11479631PubMed
918,535,580CD8+ T cell efficacy in vaccination and disease.Nat Med2008https://conductscience.org/library/papers/18535580PubMed
1010,470,079Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.Nat Med1999https://conductscience.org/library/papers/10470079PubMed

1 to 10 of 36

See all 36 references

Cited by35

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 56 citations.

PMIDTitleJournalYearIn PapersSource
41,440,022B Cells Can Trigger the T-Cell-Mediated Autoimmune Response Against Melanocytes in Psoriasis.Cells2025https://conductscience.org/library/papers/41440022PubMed
40,243,413Down-Regulation of HLA-C Expression on Melanocytes May Contribute to the Therapeutic Efficacy of UVB Phototherapy in Psoriasis.Int J Mol Sci2025https://conductscience.org/library/papers/40243413PubMed
39,774,774Endogenous CD4+ T Cells That Recognize ALK and the NPM1::ALK Fusion Protein Can Be Expanded from Human Peripheral Blood.Cancer Immunol Res2025https://conductscience.org/library/papers/39774774PubMed
39,160,299A synthetic cytotoxic T cell platform for rapidly prototyping TCR function.NPJ Precis Oncol2024https://conductscience.org/library/papers/39160299PubMed
38,524,140Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity.Front Immunol2024https://conductscience.org/library/papers/38524140PubMed
38,363,296Tsyn-Seq: a T-cell Synapse-Based Antigen Identification Platform.Cancer Immunol Res2024https://conductscience.org/library/papers/38363296PubMed
37,767,552HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation.Haematologica2024https://conductscience.org/library/papers/37767552PubMed
37,231,180Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution.Sci Rep2023https://conductscience.org/library/papers/37231180PubMed
36,700,227Immunogenic self-peptides - the great unknowns in autoimmunity: Identifying T-cell epitopes driving the autoimmune response in autoimmune diseases.Front Immunol2022https://conductscience.org/library/papers/36700227PubMed
36,122,410Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma.Cancer Immunol Res2022https://conductscience.org/library/papers/36122410PubMed

1 to 10 of 35

See all 35 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
HLA-C3,107PubTator's text mininghttps://conductscience.org/library/genes/3107NCBI Gene
TRBV20OR9-26,962PubTator's text mininghttps://conductscience.org/library/genes/6962NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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