Paper · 2250705

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.

Hockenbery D and 4 others. Nature, 1990. Cited by 3,653 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Papers, record 2250705. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2250705

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.; PubMed
Journal: Nature; PubMed
Year: 1990; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2250705/; PubMed
DOI: https://doi.org/10.1038/348334a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 3,653; iCite
Relative citation ratio, by iCite: 87.1; iCite
Revised in PubMed: 2025-02-14; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Hockenbery D	D
2	Nuñez G	G
3	Milliman C	C
4	Schreiber RD	R D
5	Korsmeyer SJ	S J

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cell Survival	Major topic
Lymphoma	Major topic
Membrane Proteins	Major topic
Mitochondria	Major topic
Oncogenes	Major topic
Proto-Oncogene Proteins	Major topic
Animals
Antibodies, Monoclonal
Base Sequence
Blotting, Western
Cell Line
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Codon
Humans
Molecular Sequence Data
Open Reading Frames
Proto-Oncogene Proteins c-bcl-2
Translocation, Genetic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by814

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3,653 citations.

PMID	Title	Journal	Year	In Papers	Source
42,882,893	Chk1/2 Inhibition by AZD7762 Enhances Andrographolide-Induced DNA Damage, Impairs DNA Repair, and Promotes Apoptosis in Head and Neck Squamous Cell Carcinoma CAL-33 Cells.	Cancers (Basel)	2026	https://conductscience.org/library/papers/42882893	PubMed
42,721,182	N-acetylcysteine attenuates oxidative-stress-associated apoptosis and collagen deposition after rat hindlimb ischemia-reperfusion injury.	PLoS One	2026	https://conductscience.org/library/papers/42721182	PubMed
42,416,494	Nephrotoxic acute kidney injury induced by Daboia siamensis venom and its fractions: assessment of Bcl-2 family expression in in vivo and ex vivo in rabbit models.	J Venom Anim Toxins Incl Trop Dis	2026	https://conductscience.org/library/papers/42416494	PubMed
42,248,141	Xenophagocytosis blockade enhances interspecies chimerism.	Cell	2026	https://conductscience.org/library/papers/42248141	PubMed
42,213,242	Regulated cell death programs shaping cancer therapy.	Cell Oncol (Dordr)	2026	https://conductscience.org/library/papers/42213242	PubMed
42,199,066	Mitophagy in cisplatin-induced kidney injury: regulatory mechanisms and therapeutic targets.	Ann Med	2026	https://conductscience.org/library/papers/42199066	PubMed
42,084,012	A century of cell death research.	J Cell Sci	2026	https://conductscience.org/library/papers/42084012	PubMed
41,929,632	Mechanistic overview and suggested strategies to overcome BCL-2 inhibitor resistance in TP53-mutated acute myeloid leukemia.	Front Cell Dev Biol	2026	https://conductscience.org/library/papers/41929632	PubMed
41,776,400	The caspase gene family in Micropterus salmoides: genome-wide characterization, bioinformatics, and expression profiling analysis.	BMC Genomics	2026	https://conductscience.org/library/papers/41776400	PubMed
41,772,680	Methyl-cantharidimide suppresses cyclin-dependent kinase 1 (CDK1) and induces oxeiptosis in liver cancer.	J Exp Clin Cancer Res	2026	https://conductscience.org/library/papers/41772680	PubMed

1 to 10 of 814

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
BCL2	596	Swiss-Prot's references	https://conductscience.org/library/genes/596	NCBI Gene
IGHD	3,495	PubTator's text mining	https://conductscience.org/library/genes/3495	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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