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Paper22952016

Quantitative measurement of invadopodia-mediated extracellular matrix proteolysis in single and multicellular contexts.

Martin KH and 5 others. J Vis Exp, 2012. Cited by 62 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Quantitative measurement of invadopodia-mediated extracellular matrix proteolysis in single and multicellular contexts. Papers, record 22952016. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/22952016

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Quantitative measurement of invadopodia-mediated extracellular matrix proteolysis in single and multicellular contexts.
PubMed
Journal
J Vis Exp
PubMed
Year
2012
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Video-Audio Media
PubMed
Citations, by iCite
62
iCite
Relative citation ratio, by iCite
1.6
iCite
Revised in PubMed
2021-10-21
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Martin KHKaren H
2Hayes KEKaren E
3Walk ELElyse L
4Ammer AGAmanda Gatesman
5Markwell SMSteven M
6Weed SAScott A

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Extracellular MatrixMajor topic
Extracellular Matrix ProteinsMajor topic
Microscopy, FluorescenceMajor topic
Carboxylic Acids
Cell Surface Extensions
Matrix Metalloproteinases
Proteolysis

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P20 RR016440NCRR NIH HHSUnited StatesP20RR016440PubMed and NIHNIH RePORTER
P30 GM103488NIGMS NIH HHSUnited StatesP30GM103488PubMed and NIHNIH RePORTER
P30 RR032138NCRR NIH HHSUnited StatesP30RR032138PubMed and NIHNIH RePORTER
P20 RR16440NCRR NIH HHSUnited StatesP20RR016440PubMed and NIHNIH RePORTER

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,938,979Fibronectin is not present in the focal adhesions formed between normal cultured fibroblasts and their substrata.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6938979PubMed
216,554,367The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages.Mol Biol Cell2006https://conductscience.org/library/papers/16554367PubMed
32,989,711Local degradation of fibronectin at sites of expression of the transforming gene product pp60src.Nature1985https://conductscience.org/library/papers/2989711PubMed
421,697,900The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function.Nat Rev Mol Cell Biol2011https://conductscience.org/library/papers/21697900PubMed
520,137,952The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion.Curr Biol2010https://conductscience.org/library/papers/20137952PubMed
615,710,328The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells.Cancer Cell2005https://conductscience.org/library/papers/15710328PubMed
720,951,132Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity.Exp Cell Res2011https://conductscience.org/library/papers/20951132PubMed
811,060,862Invadopodia: unique methods for measurement of extracellular matrix degradation in vitro.Methods Cell Biol2001https://conductscience.org/library/papers/11060862PubMed
917,483,334Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia.Cancer Res2007https://conductscience.org/library/papers/17483334PubMed
1019,704,022Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation.J Cell Biol2009https://conductscience.org/library/papers/19704022PubMed
1118,718,759Extracellular matrix rigidity promotes invadopodia activity.Curr Biol2008https://conductscience.org/library/papers/18718759PubMed
126,325,472Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites.J Cell Biol1984https://conductscience.org/library/papers/6325472PubMed
1318,198,194Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation.J Cell Sci2008https://conductscience.org/library/papers/18198194PubMed
1420,421,424Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia.J Cell Biol2010https://conductscience.org/library/papers/20421424PubMed
1520,505,783Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function.J Cancer Sci Ther2009https://conductscience.org/library/papers/20505783PubMed
1619,247,615ECM degradation assays for analyzing local cell invasion.Methods Mol Biol2009https://conductscience.org/library/papers/19247615PubMed
1720,426,790Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells.Cancer Sci2010https://conductscience.org/library/papers/20426790PubMed
1820,876,278LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.J Cell Biol2010https://conductscience.org/library/papers/20876278PubMed
1921,708,979Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation.J Cell Biol2011https://conductscience.org/library/papers/21708979PubMed
2016,540,652Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.Cancer Res2006https://conductscience.org/library/papers/16540652PubMed

See all 27 references

Cited by50

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 62 citations.

PMIDTitleJournalYearIn PapersSource
40,419,795Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells.Nat Cell Biol2025https://conductscience.org/library/papers/40419795PubMed
40,395,867Platelet-derived microvesicles drive vascular smooth muscle cell migration via forming podosomes and promoting matrix metalloproteinase-9 activity.Mechanobiol Med2023https://conductscience.org/library/papers/40395867PubMed
40,087,276ER O-glycosylation in synovial fibroblasts drives cartilage degradation.Nat Commun2025https://conductscience.org/library/papers/40087276PubMed
38,760,173The F-actin bundler SWAP-70 promotes tumor metastasis.Life Sci Alliance2024https://conductscience.org/library/papers/38760173PubMed
38,140,937Myosin 1e deficiency affects migration of 4T1 breast cancer cells.Cytoskeleton (Hoboken)2024https://conductscience.org/library/papers/38140937PubMed
37,941,562Collagen-I influences the post-translational regulation, binding partners and role of Annexin A2 in breast cancer progression.Front Oncol2023https://conductscience.org/library/papers/37941562PubMed
37,482,421FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells.Cell Struct Funct2023https://conductscience.org/library/papers/37482421PubMed
36,571,786ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia.J Cell Biol2023https://conductscience.org/library/papers/36571786PubMed
36,494,720Current methods for studying metastatic potential of tumor cells.Cancer Cell Int2022https://conductscience.org/library/papers/36494720PubMed
35,819,726Surface cholesterol-enriched domains specifically promote invasion of breast cancer cell lines by controlling invadopodia and extracellular matrix degradation.Cell Mol Life Sci2022https://conductscience.org/library/papers/35819726PubMed
35,803,110Evaluation of the matrix metalloproteinase 9 (MMP9) inhibitor Andecaliximab as an Anti-invasive therapeutic in Head and neck squamous cell carcinoma.Oral Oncol2022https://conductscience.org/library/papers/35803110PubMed
35,008,190HIF-Dependent CKB Expression Promotes Breast Cancer Metastasis, Whereas Cyclocreatine Therapy Impairs Cellular Invasion and Improves Chemotherapy Efficacy.Cancers (Basel)2021https://conductscience.org/library/papers/35008190PubMed
33,740,019Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells.PLoS One2021https://conductscience.org/library/papers/33740019PubMed
33,566,639Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion.Mol Biol Cell2021https://conductscience.org/library/papers/33566639PubMed
33,527,896SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance.Elife2021https://conductscience.org/library/papers/33527896PubMed
33,166,377A 3-dimensional microfluidic platform for modeling human extravillous trophoblast invasion and toxicological screening.Lab Chip2021https://conductscience.org/library/papers/33166377PubMed
32,858,793Identification of Potential Chemical Substrates as Fuel for Hypoxic Tumors That May Be Linked to Invadopodium Formation in Hypoxia-Induced MDA-MB-231 Breast-Cancer Cell Line.Molecules2020https://conductscience.org/library/papers/32858793PubMed
32,479,595Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion.J Cell Biol2020https://conductscience.org/library/papers/32479595PubMed
31,999,741Tks5 SH3 domains exhibit differential effects on invadopodia development.PLoS One2020https://conductscience.org/library/papers/31999741PubMed
31,865,373Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.J Cell Biol2020https://conductscience.org/library/papers/31865373PubMed

See all 50 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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