Paper · 23643243

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

Wang H and 6 others. Cell, 2013. Cited by 2,744 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Papers, record 23643243. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23643243

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.; PubMed
Journal: Cell; PubMed
Year: 2013; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/23643243/; PubMed
DOI: https://doi.org/10.1016/j.cell.2013.04.025; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3969854/; PubMed
The journal: https://conductscience.org/library/journal-index/0413066; PubMed
Citations, by iCite: 2,744; iCite
Relative citation ratio, by iCite: 70.7; iCite
Revised in PubMed: 2026-02-04; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Wang H	Haoyi
2	Yang H	Hui
3	Shivalila CS	Chikdu S
4	Dawlaty MM	Meelad M
5	Cheng AW	Albert W
6	Zhang F	Feng
7	Jaenisch R	Rudolf

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Gene Targeting	Major topic
Mice	Major topic
Animals
Base Sequence
Embryonic Stem Cells
Female
Male
Mice, Inbred C57BL
Mice, Inbred DBA
Molecular Sequence Data
RNA, Small Untranslated

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R01-CA084198	NCI NIH HHS	United States	R01CA084198	PubMed and NIH	NIH RePORTER
R37 HD045022	NICHD NIH HHS	United States	R37HD045022	PubMed and NIH	NIH RePORTER
DP1 MH100706	NIMH NIH HHS	United States	DP1MH100706	PubMed and NIH	NIH RePORTER
R01 CA084198	NCI NIH HHS	United States	R01CA084198	PubMed and NIH	NIH RePORTER
R37-HD045022	NICHD NIH HHS	United States	R37HD045022	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References34

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	23,302,927	Knockout mice created by TALEN-mediated gene targeting.	Nat Biotechnol	2013	https://conductscience.org/library/papers/23302927	PubMed
2	23,360,964	Efficient genome editing in zebrafish using a CRISPR-Cas system.	Nat Biotechnol	2013	https://conductscience.org/library/papers/23360964	PubMed
3	21,892,189	The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.	Nature	2011	https://conductscience.org/library/papers/21892189	PubMed
4	21,910,633	Double-strand break end resection and repair pathway choice.	Annu Rev Genet	2011	https://conductscience.org/library/papers/21910633	PubMed
5	23,360,965	RNA-guided editing of bacterial genomes using CRISPR-Cas systems.	Nat Biotechnol	2013	https://conductscience.org/library/papers/23360965	PubMed
6	23,426,636	Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.	Proc Natl Acad Sci U S A	2013	https://conductscience.org/library/papers/23426636	PubMed
7	21,803,851	Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies.	Blood	2011	https://conductscience.org/library/papers/21803851	PubMed
8	21,757,228	Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.	Cell	2011	https://conductscience.org/library/papers/21757228	PubMed
9	23,352,810	Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.	Dev Cell	2013	https://conductscience.org/library/papers/23352810	PubMed
10	21,960,622	TAL effectors: customizable proteins for DNA targeting.	Science	2011	https://conductscience.org/library/papers/21960622	PubMed

1 to 10 of 34

See all 34 references

Cited by1,975

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,744 citations.

PMID	Title	Journal	Year	In Papers	Source
42,988,810	Consecutive waves of NODAL inhibition are required for epiblast patterning.	Nat Commun	2026	https://conductscience.org/library/papers/42988810	PubMed
42,909,932	Recent advances in CRISPR technologies for biomedical applications and disease treatment.	Theranostics	2026	https://conductscience.org/library/papers/42909932	PubMed
42,891,351	Strategies and mechanisms of precision genome engineering: From gene editing to genome writing.	IMetaOmics	2026	https://conductscience.org/library/papers/42891351	PubMed
42,728,430	Structural evolution of ionizable lipids for nucleic acid delivery.	Nat Rev Chem	2026	https://conductscience.org/library/papers/42728430	PubMed
42,627,856	Caveolin 1 is a conserved host factor mediating Bacillus cereus hemolysin BL toxin cytolytic toxicity.	PLoS Biol	2026	https://conductscience.org/library/papers/42627856	PubMed
42,584,780	Generation and Validation of an Acan-Cre Mouse Line to Selectively Label Class-B Excitatory Neurons of the Cerebellar Nuclei.	Cerebellum	2026	https://conductscience.org/library/papers/42584780	PubMed
42,578,365	Specific cleavage of 5' overhangs of non-target strand by Cas9 activated by target DNA binding.	Nucleic Acids Res	2026	https://conductscience.org/library/papers/42578365	PubMed
42,391,007	Overcoming the challenges of genome-editing essential genes.	STAR Protoc	2026	https://conductscience.org/library/papers/42391007	PubMed
42,363,245	A streamlined approach for gene editing in non-obese diabetes (NOD) mice via CRISPR/Cas9.	Lab Anim Res	2026	https://conductscience.org/library/papers/42363245	PubMed
42,315,520	Deep learning-guided engineering of SpuFz1 and rational miniaturization of ωRNA enables efficient genome editing.	Nat Commun	2026	https://conductscience.org/library/papers/42315520	PubMed

1 to 10 of 1,975

See all 1,975 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
TET2	54,790	PubTator's text mining	https://conductscience.org/library/genes/54790

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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