Paper2409005

Alpha 2-macroglobulin secretion enhanced in rat hepatocytes by partially characterized factor from Kupffer cells.

Hirata Y and 5 others. Inflammation, 1985. Cited by 25 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Alpha 2-macroglobulin secretion enhanced in rat hepatocytes by partially characterized factor from Kupffer cells. Papers, record 2409005. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2409005

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Alpha 2-macroglobulin secretion enhanced in rat hepatocytes by partially characterized factor from Kupffer cells.; PubMed
Journal: Inflammation; PubMed
Year: 1985; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/2409005/; PubMed
DOI: https://doi.org/10.1007/bf00917592; PubMed
The journal: https://conductscience.org/library/journal-index/7600105; PubMed
Citations, by iCite: 25; iCite
Relative citation ratio, by iCite: 0.76; iCite
Revised in PubMed: 2026-10-11; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Hirata Y	Y
2	Ishibashi H	H
3	Kimura H	H
4	Hayashida K	K
5	Nagano M	M
6	Okubo H	H

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Kupffer Cells	Major topic
Liver	Major topic
alpha-Macroglobulins	Major topic
Animals
Cells, Cultured
Dactinomycin
Hot Temperature
Kinetics
Lipopolysaccharides
Male
Molecular Weight
Rats
Rats, Inbred Strains

Source PubMed

Show 7 more topicsShow fewer topics

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	338,897	Characteristics of pyrogen production by isolated rabbit Kupffer cells in vitro.	J Reticuloendothel Soc	1977	https://conductscience.org/library/papers/338897	PubMed
2	4,691,265	Multiple biological activities of a partially purified leukocytic endogenous mediator.	Am J Physiol	1973	https://conductscience.org/library/papers/4691265	PubMed
3	6,791,835	Ability of human leukocytic pyrogen to enhance phytohemagglutinin induced murine thymocyte proliferation.	Cell Immunol	1981	https://conductscience.org/library/papers/6791835	PubMed
4	1,269,536	Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation.	Exp Cell Res	1976	https://conductscience.org/library/papers/1269536	PubMed
5	448,118	Characterization of lymphocyte-activating factor (LAF) produced by human mononuclear cells: biochemical relationship of high and low molecular weight forms of LAF.	J Immunol	1979	https://conductscience.org/library/papers/448118	PubMed
6	6,780,623	Purification to apparent homogeneity of murine interleukin 1.	J Immunol	1981	https://conductscience.org/library/papers/6780623	PubMed
7	6,164,401	Purification and immunological determination of alpha 2-macroglobulin in serum from injured rats.	Biochim Biophys Acta	1981	https://conductscience.org/library/papers/6164401	PubMed
8	6,791,836	The role of macrophages in the acute-phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogen.	Cell Immunol	1981	https://conductscience.org/library/papers/6791836	PubMed
9	7,402,294	Monokine-induced synthesis of serum amyloid A protein by hepatocytes.	Nature	1980	https://conductscience.org/library/papers/7402294	PubMed
10	6,658,710	Kupffer cell regulation of fibrinogen synthesis in hepatocytes.	Thromb Res	1983	https://conductscience.org/library/papers/6658710	PubMed
11	6,461,860	Regulation of fibrinogen synthesis by plasmin-derived fragments of fibrinogen and fibrin: an indirect feedback pathway.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6461860	PubMed
12	1,090,696	Mass isolation and culture of rat kupffer cells.	J Exp Med	1975	https://conductscience.org/library/papers/1090696	PubMed
13	6,180,977	Effect of alpha 2-macroglobulin on the lymphocyte response.	Immunology	1982	https://conductscience.org/library/papers/6180977	PubMed
14	177,845	Preparation of isolated rat liver cells.	Methods Cell Biol	1976	https://conductscience.org/library/papers/177845	PubMed
15	6,965,973	Endogenous pyrogens made by rabbit peritoneal exudate cells are identical with lymphocyte-activating factors made by rabbit alveolar macrophages.	J Immunol	1980	https://conductscience.org/library/papers/6965973	PubMed
16	6,800,841	Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.	Fed Proc	1982	https://conductscience.org/library/papers/6800841	PubMed

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Cited by2

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 25 citations.

PMID	Title	Journal	Year	In Papers	Source
3,327,805	Restoration of the LPS responsive phenotype in C3H/HeJ macrophage hybrids: LPS regulation of hepatocyte-stimulating factor production.	Immunology	1987	https://conductscience.org/library/papers/3327805	PubMed
1,689,567	Interleukin-6 and the acute phase response.	Biochem J	1990	https://conductscience.org/library/papers/1689567	PubMed

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
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NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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