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Paper · 24252274

Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis.

Freischmidt A and 3 others. Acta Neuropathol Commun, 2013. Cited by 133 papers, by iCite.

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ConductScience Library. Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis. Papers, record 24252274. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24252274

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis.
PubMed
Journal
Acta Neuropathol Commun
PubMed
Year
2013
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
133
iCite
Relative citation ratio, by iCite
3.99
iCite
Revised in PubMed
2023-11-04
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Freischmidt AAxel
2Müller KKathrin
3Ludolph ACAlbert C
4Weishaupt JHJochen H

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Amyotrophic Lateral SclerosisMajor topic
DNA-Binding ProteinsMajor topic
MicroRNAsMajor topic
Cell Line
Cohort Studies
Female
Humans
Male
Middle Aged
Mutation
Reverse Transcriptase Polymerase Chain Reaction

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References41

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
119,833,869TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.Proc Natl Acad Sci U S A2009https://conductscience.org/library/papers/19833869PubMed
219,165,215Biogenesis of small RNAs in animals.Nat Rev Mol Cell Biol2009https://conductscience.org/library/papers/19165215PubMed
321,944,778Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS.Neuron2011https://conductscience.org/library/papers/21944778PubMed
48,622,453Skin involvement in amyotrophic lateral sclerosis.Lancet1996https://conductscience.org/library/papers/8622453PubMed
522,323,604TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.Proc Natl Acad Sci U S A2012https://conductscience.org/library/papers/22323604PubMed
619,450,959Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells.Curr Opin Cell Biol2009https://conductscience.org/library/papers/19450959PubMed
711,328,886A new mathematical model for relative quantification in real-time RT-PCR.Nucleic Acids Res2001https://conductscience.org/library/papers/11328886PubMed
820,844,043Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus.J Virol2010https://conductscience.org/library/papers/20844043PubMed
919,125,255Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.Acta Neuropathol2009https://conductscience.org/library/papers/19125255PubMed
1022,895,706TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.J Neurosci2012https://conductscience.org/library/papers/22895706PubMed

1 to 10 of 41

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Cited by100

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 133 citations.

PMIDTitleJournalYearIn PapersSource
42,070,160miRNAs in Amyotrophic Lateral Sclerosis: Tiny Molecules, Tremendous Impact.Mol Neurobiol2026https://conductscience.org/library/papers/42070160PubMed
41,888,437Preservation of miR-9-5p and miR-124-3p in ALS-resistant oculomotor neurons contrasts with their downregulation in vulnerable spinal motor neurons, irrespective of TDP-43 pathology.Acta Neuropathol2026https://conductscience.org/library/papers/41888437PubMed
40,873,389Intracellular and Extracellular Vesicle miRNA Signatures in Human iPSC-Derived Neural Stem Cells and Floor Plate Progenitors.FASEB J2025https://conductscience.org/library/papers/40873389PubMed
40,618,254MicroRNAs in the pathogenesis of neurodegenerative disorders: Potential as therapeutic targets.Neural Regen Res2026https://conductscience.org/library/papers/40618254PubMed
40,347,374Exploring Exosome-Based Approaches for Early Diagnosis and Treatment of Neurodegenerative Diseases.Mol Neurobiol2025https://conductscience.org/library/papers/40347374PubMed
40,301,571Cross-tissue MiRNA profiling of extracellular vesicles and PBMCs from amyotrophic lateral sclerosis patients.Sci Rep2025https://conductscience.org/library/papers/40301571PubMed
39,570,437Exploring dysregulated miRNAs in ALS: implications for disease pathogenesis and early diagnosis.Neurol Sci2025https://conductscience.org/library/papers/39570437PubMed
39,456,682A Review of Biomarkers of Amyotrophic Lateral Sclerosis: A Pathophysiologic Approach.Int J Mol Sci2024https://conductscience.org/library/papers/39456682PubMed
39,337,908Expression Changes of miRNAs in Humans and Animal Models of Amyotrophic Lateral Sclerosis and Their Potential Application for Clinical Diagnosis.Life (Basel)2024https://conductscience.org/library/papers/39337908PubMed
38,921,029The Neuromuscular Disorder Mediated by Extracellular Vesicles in Amyotrophic Lateral Sclerosis.Curr Issues Mol Biol2024https://conductscience.org/library/papers/38921029PubMed

1 to 10 of 100

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Genes19

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
C9orf72203,228PubTator's text mininghttps://conductscience.org/library/genes/203228NCBI Gene
CEL1,056PubTator's text mininghttps://conductscience.org/library/genes/1056NCBI Gene
DICER123,405PubTator's text mininghttps://conductscience.org/library/genes/23405NCBI Gene
DROSHA29,102PubTator's text mininghttps://conductscience.org/library/genes/29102NCBI Gene
FUS2,521PubTator's text mininghttps://conductscience.org/library/genes/2521NCBI Gene
MIR132406,921PubTator's text mininghttps://conductscience.org/library/genes/406921NCBI Gene
MIR1323100,302,255PubTator's text mininghttps://conductscience.org/library/genes/100302255NCBI Gene
MIR143406,935PubTator's text mininghttps://conductscience.org/library/genes/406935NCBI Gene
MIR155406,947PubTator's text mininghttps://conductscience.org/library/genes/406947NCBI Gene
MIR558693,143PubTator's text mininghttps://conductscience.org/library/genes/693143NCBI Gene

1 to 10 of 19

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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