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Paper2452015

Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells.

Mulé JJ and 4 others. Cancer Immunol Immunother, 1988. Cited by 180 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells. Papers, record 2452015. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2452015

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells.
PubMed
Journal
Cancer Immunol Immunother
PubMed
Year
1988
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
180
iCite
Relative citation ratio, by iCite
4.14
iCite
Revised in PubMed
2024-04-26
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Mulé JJJ J
2Schwarz SLS L
3Roberts ABA B
4Sporn MBM B
5Rosenberg SAS A

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cytotoxicity, ImmunologicMajor topic
Immunosuppressive AgentsMajor topic
Killer Cells, NaturalMajor topic
Lymphocyte ActivationMajor topic
PeptidesMajor topic
T-Lymphocytes, CytotoxicMajor topic
Animals
Epitopes
Humans
Isoantigens
Lymphocyte Culture Test, Mixed
Lymphokines
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred DBA
Platelet-Derived Growth Factor
Transforming Growth Factors

Source PubMed

References42

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,605,993Inhibition of interleukin 2 production by factors released from tumor cells.J Immunol1983https://conductscience.org/library/papers/6605993PubMed
23,886,826Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2.J Exp Med1985https://conductscience.org/library/papers/3886826PubMed
33,903,508Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer.N Engl J Med1985https://conductscience.org/library/papers/3903508PubMed
43,856,735Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.Mol Cell Biol1985https://conductscience.org/library/papers/3856735PubMed
53,893,689Successful immunotherapy of murine experimental hepatic metastases with lymphokine-activated killer cells and recombinant interleukin 2.Cancer Res1985https://conductscience.org/library/papers/3893689PubMed
63,497,030T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.EMBO J1987https://conductscience.org/library/papers/3497030PubMed
73,486,223In vitro sensitization and expansion with viable tumor cells and interleukin 2 in the generation of specific therapeutic effector cells.J Immunol1986https://conductscience.org/library/papers/3486223PubMed
82,906,217Transforming growth factor beta.Adv Cancer Res1988https://conductscience.org/library/papers/2906217PubMed
96,608,989Lymphokine-activated killer cells: lysis of fresh syngeneic natural killer-resistant murine tumor cells by lymphocytes cultured in interleukin 2.Cancer Res1984https://conductscience.org/library/papers/6608989PubMed
103,485,134Therapy of murine leukemia with cyclophosphamide and immune Lyt-2+ cells: cytolytic T cells can mediate eradication of disseminated leukemia.J Immunol1986https://conductscience.org/library/papers/3485134PubMed
113,157,440Identification and characterization of a tumor-derived immunosuppressive glycoprotein from murine melanoma K-1735.Cancer Immunol Immunother1985https://conductscience.org/library/papers/3157440PubMed
124,345,108Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor.J Exp Med1972https://conductscience.org/library/papers/4345108PubMed
137,047,385Inhibition of cytokine production by a tumor cell product.Immunology1982https://conductscience.org/library/papers/7047385PubMed
146,619,930Presence of immunosuppressive factors in brain-tumor cyst fluid.J Neurosurg1983https://conductscience.org/library/papers/6619930PubMed
153,857,579Purification and characterization of two cartilage-inducing factors from bovine demineralized bone.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3857579PubMed
163,108,401Identification of cellular mechanisms operational in vivo during the regression of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin 2.J Immunol1987https://conductscience.org/library/papers/3108401PubMed
172,871,107Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.J Immunol1986https://conductscience.org/library/papers/2871107PubMed
187,019,327In vitro growth of murine T cells. VI. Accelerated skin graft rejection caused by adoptively transferred cells expanded in T cell growth factor.J Immunol1981https://conductscience.org/library/papers/7019327PubMed
196,601,147The fate of interleukin-2 after in vivo administration.J Immunol1983https://conductscience.org/library/papers/6601147PubMed
203,500,355In vivo antitumor activity of tumor-infiltrating lymphocytes expanded in recombinant interleukin-2.J Natl Cancer Inst1987https://conductscience.org/library/papers/3500355PubMed

See all 42 references

Cited by49

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 180 citations.

PMIDTitleJournalYearIn PapersSource
40,027,190Nutraceutical Evaluation of Trigonelline's Therapeutic Potential by Targeting Bladder Cancer Stem Cells and Cancer-Associated Fibroblasts via Downregulation of TGFβ3/GLI2/YAP1 Signaling Hub.Int J Med Sci2025https://conductscience.org/library/papers/40027190PubMed
37,829,123A novel GPI-anchored dominant-negative TGF-β receptor II renders T cells unresponsive to TGF-β signaling.Mol Ther Oncolytics2023https://conductscience.org/library/papers/37829123PubMed
36,982,677Interplay between Signaling Pathways and Tumor Microenvironment Components: A Paradoxical Role in Colorectal Cancer.Int J Mol Sci2023https://conductscience.org/library/papers/36982677PubMed
36,142,615Immune Tumor Microenvironment in Ovarian Cancer Ascites.Int J Mol Sci2022https://conductscience.org/library/papers/36142615PubMed
33,323,456Neutralization of TGFβ Improves Tumor Immunity and Reduces Tumor Progression in Ovarian Carcinoma.Mol Cancer Ther2021https://conductscience.org/library/papers/33323456PubMed
31,091,744Review: Targeting the Transforming Growth Factor-Beta Pathway in Ovarian Cancer.Cancers (Basel)2019https://conductscience.org/library/papers/31091744PubMed
28,575,585Transforming growth factor-β: A therapeutic target for cancer.Hum Vaccin Immunother2017https://conductscience.org/library/papers/28575585PubMed
24,376,448Regulation of mouse NK cell development and function by cytokines.Front Immunol2013https://conductscience.org/library/papers/24376448PubMed
23,553,431Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy.Biol Reprod2013https://conductscience.org/library/papers/23553431PubMed
21,741,424Immunotherapy in prostate cancer: emerging strategies against a formidable foe.Vaccine2011https://conductscience.org/library/papers/21741424PubMed
21,317,622Therapeutic cancer vaccines: the latest advancement in targeted therapy.Am J Ther2012https://conductscience.org/library/papers/21317622PubMed
20,018,551Transforming growth factor beta (TGF-beta) and inflammation in cancer.Cytokine Growth Factor Rev2010https://conductscience.org/library/papers/20018551PubMed
17,579,858Immunological profiling of a panel of human ovarian cancer cell lines.Cancer Immunol Immunother2008https://conductscience.org/library/papers/17579858PubMed
17,243,202Cancer gene therapy: the power of negative thinking.Gene Ther2006https://conductscience.org/library/papers/17243202PubMed
17,031,640Vaccination therapy in prostate cancer.Cancer Immunol Immunother2007https://conductscience.org/library/papers/17031640PubMed
16,123,803TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia.Oncogene2005https://conductscience.org/library/papers/16123803PubMed
14,657,224
Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.
J Exp Med2003https://conductscience.org/library/papers/14657224PubMed
11,509,946Cytokine gene therapy of gliomas: effective induction of therapeutic immunity to intracranial tumors by peripheral immunization with interleukin-4 transduced glioma cells.Gene Ther2001https://conductscience.org/library/papers/11509946PubMed
10,712,667An acidic microenvironment impairs the generation of non-major histocompatibility complex-restricted killer cells.Immunology2000https://conductscience.org/library/papers/10712667PubMed
10,193,412Inhibitory effects of transforming growth factor-beta (TGF-beta) on certain functions of intraepithelial lymphocytes.Clin Exp Immunol1999https://conductscience.org/library/papers/10193412PubMed

See all 49 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
IL23,558PubTator's text mininghttps://conductscience.org/library/genes/3558NCBI Gene
TGFB17,040PubTator's text mininghttps://conductscience.org/library/genes/7040NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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