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Paper · 24909166

Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages.

Kumar S and 13 others. Oncogene, 2015. Cited by 51 papers, by iCite.

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ConductScience Library. Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages. Papers, record 24909166. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24909166

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages.
PubMed
Journal
Oncogene
PubMed
Year
2015
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
51
iCite
Relative citation ratio, by iCite
1.41
iCite
Revised in PubMed
2026-11-02
PubMed

Authors14

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kumar SS
2Torres MPM P
3Kaur SS
4Rachagani SS
5Joshi SS
6Johansson SLS L
7Momi NN
8Baine MJM J
9Gilling CEC E
10Smith LML M

1 to 10 of 14Source PubMed

See all 14 authors

Topics26

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carcinoma in SituMajor topic
Heparin-binding EGF-like Growth FactorMajor topic
MacrophagesMajor topic
Myeloid CellsMajor topic
Pancreatic NeoplasmsMajor topic
SmokingMajor topic
Acinar Cells
Animals
Carcinoma, Pancreatic Ductal
Cell Differentiation
Chemokine CXCL2
Dendritic Cells
Disease Progression
Genes, ras
Inflammation
Interferon-gamma
Keratin-19
Metaplasia
Mice
Mice, Transgenic
Pancreatic Ducts
Pancreatic Stellate Cells
Receptors, Retinoic Acid
Signal Transduction
Smoke
Tretinoin

Source PubMed

Grants9

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
U54 CA163120NCI NIH HHSUnited StatesU54CA163120PubMed and NIHNIH RePORTER
U01 CA111294NCI NIH HHSUnited StatesU01CA111294PubMed and NIHNIH RePORTER
R01CA78590NCI NIH HHSUnited StatesR01CA078590PubMed and NIHNIH RePORTER
P50 CA127297NCI NIH HHSUnited StatesP50CA127297PubMed and NIHNIH RePORTER
R01 CA131944NCI NIH HHSUnited StatesR01CA131944PubMed and NIHNIH RePORTER
R01 CA133774NCI NIH HHSUnited StatesR01CA133774PubMed and NIHNIH RePORTER
P20 GM103480NIGMS NIH HHSUnited StatesP20GM103480PubMed and NIHNIH RePORTER
R21CA156037NIHNIH RePORTER
T32CA009476NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References53

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,905,575Biochemical and functional characterization of three activated macrophage populations.J Leukoc Biol2006https://conductscience.org/library/papers/16905575PubMed
216,424,049Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.Cancer Res2006https://conductscience.org/library/papers/16424049PubMed
322,162,230Epidemiology and potential mechanisms of tobacco smoking and heavy alcohol consumption in pancreatic cancer.Mol Carcinog2012https://conductscience.org/library/papers/22162230PubMed
418,606,709Cigarette smoke-induced oxidative stress suppresses generation of dendritic cell IL-12 and IL-23 through ERK-dependent pathways.J Immunol2008https://conductscience.org/library/papers/18606709PubMed
522,614,008Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation.Oncogene2013https://conductscience.org/library/papers/22614008PubMed
616,043,492Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis.Gut2006https://conductscience.org/library/papers/16043492PubMed
718,392,050Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia.Br J Cancer2008https://conductscience.org/library/papers/18392050PubMed
812,930,397All-trans retinoic acid skews monocyte differentiation into interleukin-12-secreting dendritic-like cells.Br J Haematol2003https://conductscience.org/library/papers/12930397PubMed
99,679,048Identification, culture, and characterization of pancreatic stellate cells in rats and humans.Gastroenterology1998https://conductscience.org/library/papers/9679048PubMed
1016,754,475Differential in vivo effects of whole cigarette smoke exposure versus cigarette smoke extract on mouse ciliated tracheal epithelium.Exp Lung Res2006https://conductscience.org/library/papers/16754475PubMed

1 to 10 of 53

See all 53 references

Cited by40

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 51 citations.

PMIDTitleJournalYearIn PapersSource
42,373,998Acinar-ductal metaplasia in pancreatitis and pancreatic ductal adenocarcinoma.Cell Oncol (Dordr)2026https://conductscience.org/library/papers/42373998PubMed
42,370,145Research progress on the etiology and pathogenesis of pancreatic cancer: a narrative review.Front Oncol2026https://conductscience.org/library/papers/42370145PubMed
41,904,584Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment.Mol Cancer2026https://conductscience.org/library/papers/41904584PubMed
41,220,771Effects of current smoking on treatment outcomes in metastatic and locally advanced pancreatic carcinoma: a retrospective cohort study using the international PURPLE pancreas cancer registry.J Gastrointest Oncol2025https://conductscience.org/library/papers/41220771PubMed
40,905,825Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization.Cancer Discov2026https://conductscience.org/library/papers/40905825PubMed
40,519,307Global, regional, and national burdens of pancreatic cancer attributable to smoking from 1990 to 2021 and the projections to 2035:a systematic analysis from the global burden of disease study 2021.Front Oncol2025https://conductscience.org/library/papers/40519307PubMed
40,104,059Smoking-induced gut microbial dysbiosis mediates cancer progression through modulation of anti-tumor immune response.iScience2025https://conductscience.org/library/papers/40104059PubMed
37,474,750TRAF3/STAT6 axis regulates macrophage polarization and tumor progression.Cell Death Differ2023https://conductscience.org/library/papers/37474750PubMed
37,342,091Immunoprofiling bronchoalveolar lavage cells reveals multifaceted smoking-associated immune dysfunction.ERJ Open Res2023https://conductscience.org/library/papers/37342091PubMed
36,624,189Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis.Oncogene2023https://conductscience.org/library/papers/36624189PubMed

1 to 10 of 40

See all 40 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
KRAS3,845PubTator's text mininghttps://conductscience.org/library/genes/3845NCBI Gene
KRT193,880PubTator's text mininghttps://conductscience.org/library/genes/3880NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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