Paper24940596

Toxoplasma gondii decreases the reproductive fitness in mice.

Dvorakova-Hortova K and 8 others. PLoS One, 2014. Cited by 40 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Toxoplasma gondii decreases the reproductive fitness in mice. Papers, record 24940596. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24940596

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Toxoplasma gondii decreases the reproductive fitness in mice.; PubMed
Journal: PLoS One; PubMed
Year: 2014; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/24940596/; PubMed
DOI: https://doi.org/10.1371/journal.pone.0096770; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4062421/; PubMed
The journal: https://conductscience.org/library/journal-index/101285081; PubMed
Citations, by iCite: 40; iCite
Relative citation ratio, by iCite: 1.75; iCite
Revised in PubMed: 2024-11-05; PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Dvorakova-Hortova K	Katerina
2	Sidlova A	Adela
3	Ded L	Lukas
4	Hladovcova D	Denisa
5	Vieweg M	Markus
6	Weidner W	Wolfgang
7	Steger K	Klaus
8	Stopka P	Pavel
9	Paradowska-Dogan A	Agnieszka

Source PubMed

Show 3 more authorsShow fewer authors

Topics22

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Epididymis	Major topic
Genetic Fitness	Major topic
Seminiferous Tubules	Major topic
Sertoli Cells	Major topic
Toxoplasma	Major topic
Toxoplasmosis, Animal	Major topic
Animals
CpG Islands
Cyclic AMP Response Element Modulator
Cyclic AMP Response Element-Binding Protein
DNA Methylation
Epigenesis, Genetic
Gene Expression
HSP70 Heat-Shock Proteins
Host-Parasite Interactions
Humans
Luteinizing Hormone
Male
Mice
Mice, Inbred C57BL
Oligospermia
Spermatozoa

Source PubMed

Show 16 more topicsShow fewer topics

References53

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	2,791,968	Correlative morphology and endocrinology of Sertoli cells in hamster testes in active and inactive states of spermatogenesis.	Endocrinology	1989	https://conductscience.org/library/papers/2791968	PubMed
2	22,017,443	Comparative histopathology of mice infected with the 17XL and 17XNL strains of Plasmodium yoelii.	J Parasitol	2012	https://conductscience.org/library/papers/22017443	PubMed
3	12,390,281	Toxoplasma gondii: transmission, diagnosis and prevention.	Clin Microbiol Infect	2002	https://conductscience.org/library/papers/12390281	PubMed
4	17,210,747	Male congenital hypothyroid Pax8-/- mice are infertile despite adequate treatment with thyroid hormone.	J Endocrinol	2007	https://conductscience.org/library/papers/17210747	PubMed
5	21,507,395	Abnormal methylation of the promoter of CREM is broadly associated with male factor infertility and poor sperm quality but is improved in sperm selected by density gradient centrifugation.	Fertil Steril	2011	https://conductscience.org/library/papers/21507395	PubMed
6	11,988,318	The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis.	Mol Cell Endocrinol	2002	https://conductscience.org/library/papers/11988318	PubMed
7	21,449,042	Changes in the levels of DNA methylation in testis and liver of SD rats neonatally exposed to 5-aza-2'-deoxycytidine and cadmium.	J Appl Toxicol	2011	https://conductscience.org/library/papers/21449042	PubMed
8	10,072,323	Functional and quantitative analysis of splenic T cell immune responses following oral toxoplasma gondii infection in mice.	Exp Parasitol	1999	https://conductscience.org/library/papers/10072323	PubMed
9	20,144,980	Hormonal regulation of male germ cell development.	J Endocrinol	2010	https://conductscience.org/library/papers/20144980	PubMed
10	16,107,712	Reduction of spermatogenesis but not fertility in Creb3l4-deficient mice.	Mol Cell Biol	2005	https://conductscience.org/library/papers/16107712	PubMed
12	12,773,099	Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood.	Reproduction	2003	https://conductscience.org/library/papers/12773099	PubMed
13	16,407,497	Adult sertoli cells are not terminally differentiated in the Djungarian hamster: effect of FSH on proliferation and junction protein organization.	Biol Reprod	2006	https://conductscience.org/library/papers/16407497	PubMed
14	17,994,007	The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA.	Nature	2007	https://conductscience.org/library/papers/17994007	PubMed
15	1,661,182	Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms.	Biol Reprod	1991	https://conductscience.org/library/papers/1661182	PubMed
16	19,164,176	Proliferative activity in vitro and DNA repair indicate that adult mouse and human Sertoli cells are not terminally differentiated, quiescent cells.	Biol Reprod	2009	https://conductscience.org/library/papers/19164176	PubMed
17	19,063,884	Toxoplasma gondii: reproductive parameters in experimentally infected male rats.	Exp Parasitol	2009	https://conductscience.org/library/papers/19063884	PubMed
18	20,724,161	Epigenetic reprogramming of host genes in viral and microbial pathogenesis.	Trends Microbiol	2010	https://conductscience.org/library/papers/20724161	PubMed
19	11,483,355	The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis.	Gene	2001	https://conductscience.org/library/papers/11483355	PubMed
20	12,933,639	Molecular mechanisms controlling Sertoli cell proliferation and differentiation.	Endocrinology	2003	https://conductscience.org/library/papers/12933639	PubMed
21	19,148,668	Immunohistochemical analysis of cAMP response element-binding protein in mouse testis during postnatal development and spermatogenesis.	Histochem Cell Biol	2009	https://conductscience.org/library/papers/19148668	PubMed

Show 14 more referencesShow fewer referencesSee all 53 references

Cited by28

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 40 citations.

PMID	Title	Journal	Year	In Papers	Source
42,637,859	Chronic Toxoplasma gondii infection and its influence on semen analysis in rats: controlled experimental animal study.	Sci Rep	2026	https://conductscience.org/library/papers/42637859	PubMed
42,384,090	The Effect of Curcumin on Chronic Toxoplasma gondii Infection in the Testes of BALB/c Mice.	Acta Parasitol	2026	https://conductscience.org/library/papers/42384090	PubMed
42,188,900	Toxoplasma gondii as a Direct Cause of Reproductive Dysfunction: Dual Threats to Male and Female Fertility.	Vet Sci	2026	https://conductscience.org/library/papers/42188900	PubMed
41,536,092	Pathology and parasite distribution in mice challenged with Toxoplasma gondii from different geographical origins.	Parasitology	2026	https://conductscience.org/library/papers/41536092	PubMed
41,122,692	Amphibian Chytrid Fungus Infection Influences Calling Investment in Male Brown Toadlets.	Ecol Evol	2025	https://conductscience.org/library/papers/41122692	PubMed
40,474,948	Potential Role of CREM in Diabetes-Associated Testicular Dysfunction: Current Evidence and Future Perspectives.	Reprod Med Biol	2025	https://conductscience.org/library/papers/40474948	PubMed
40,425,049	Devastating disease can cause increased breeding effort and success that improves population resilience.	Open Biol	2025	https://conductscience.org/library/papers/40425049	PubMed
39,853,507	Toxoplasma gondii Infection in the Male Reproductive System: A Systematic Review.	Acta Parasitol	2025	https://conductscience.org/library/papers/39853507	PubMed
39,537,682	The degree of toxoplasmosis and testicular histomorphometry in rats.	Sci Rep	2024	https://conductscience.org/library/papers/39537682	PubMed
38,915,887	Seroprevalence of infectious pathogens of zoonotic and veterinary importance in wild ruminants from Slovenia.	Front Vet Sci	2024	https://conductscience.org/library/papers/38915887	PubMed
38,568,993	Toxoplasma gondii infection and testosterone alteration: A systematic review and meta-analyses.	PLoS One	2024	https://conductscience.org/library/papers/38568993	PubMed
37,719,029	Effects of Lactobacilli acidophilus and/or spiramycin as an adjunct in toxoplasmosis infection challenged with diabetes.	Food Waterborne Parasitol	2023	https://conductscience.org/library/papers/37719029	PubMed
37,628,737	Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility.	Int J Mol Sci	2023	https://conductscience.org/library/papers/37628737	PubMed
36,982,803	Infection of Trichinella spiralis Affects the Reproductive Capacity of ICR/CD-1 Male Mice by Reducing the Urine Pheromone Contents and Sperm Quality.	Int J Mol Sci	2023	https://conductscience.org/library/papers/36982803	PubMed
36,839,571	A Systematic Review of Apicomplexa Looking into Epigenetic Pathways and the Opportunity for Novel Therapies.	Pathogens	2023	https://conductscience.org/library/papers/36839571	PubMed
36,830,543	Infection with Cryptosporidium parvum Affects Secondary Sexual Characteristics of Male Mice by Altering the Pheromone Content in Preputial Gland.	Animals (Basel)	2023	https://conductscience.org/library/papers/36830543	PubMed
35,237,531	Epigenetic Manipulation of Psychiatric Behavioral Disorders Induced by Toxoplasma gondii.	Front Cell Infect Microbiol	2022	https://conductscience.org/library/papers/35237531	PubMed
34,295,033	Toxoplasma gondii induced sperm DNA damage on the experimentally infected rats.	J Parasit Dis	2021	https://conductscience.org/library/papers/34295033	PubMed
33,266,056	Effect of Toxoplasma gondii on Ram Sperm Quality After Experimental Infection.	Pathogens	2020	https://conductscience.org/library/papers/33266056	PubMed
33,013,270	Curcumin as an indirect methylation inhibitor modulates the effects of Toxoplasma gondii on genes involved in male fertility.	EXCLI J	2020	https://conductscience.org/library/papers/33013270	PubMed

Show 14 more cited byShow fewer cited bySee all 28 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
HSPA1A	3,303	PubTator's text mining	https://conductscience.org/library/genes/3303

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

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Trials
Comments and corrections
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Data

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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