Paper · 25596178

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.

Martinelli P and 6 others. Gut, 2016. Cited by 79 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice. Papers, record 25596178. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/25596178

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.; PubMed
Journal: Gut; PubMed
Year: 2016; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/25596178/; PubMed
DOI: https://doi.org/10.1136/gutjnl-2014-308042; PubMed
The journal: https://conductscience.org/library/journal-index/2985108R; PubMed
Citations, by iCite: 79; iCite
Relative citation ratio, by iCite: 2.1; iCite
Revised in PubMed: 2016-02-13; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Martinelli P	Paola
2	Madriles F	Francesc
3	Cañamero M	Marta
4	Pau EC	Enrique Carrillo-de Santa
5	Pozo ND	Natalia Del
6	Guerra C	Carmen
7	Real FX	Francisco X

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Acinar Cells	Major topic
Biomarkers, Tumor	Major topic
Carcinogenesis	Major topic
Carcinoma, Pancreatic Ductal	Major topic
GATA6 Transcription Factor	Major topic
Pancreatic Neoplasms	Major topic
Animals
Cell Differentiation
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Transgenic
Mutation
Proto-Oncogene Proteins p21(ras)

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by62

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 79 citations.

PMID	Title	Journal	Year	In Papers	Source
42,244,674	GATA4 loss promotes mutant Kras-driven pancreatic ductal adenocarcinoma in the absence of canonical precursor lesions.	bioRxiv	2026	https://conductscience.org/library/papers/42244674	PubMed
42,237,897	Transcriptomic regulation of pancreatic acinar cell homeostasis and plasticity.	Biochem Soc Trans	2026	https://conductscience.org/library/papers/42237897	PubMed
42,212,319	Heparanase 2 (Hpa2) protects the exocrine pancreas from damages of Western diet and pancreatic cancer.	Int J Biol Sci	2026	https://conductscience.org/library/papers/42212319	PubMed
42,174,151	Twist1 overexpression models an aggressive subtype of pancreatic ductal adenocarcinoma in vivo.	Lab Anim (NY)	2026	https://conductscience.org/library/papers/42174151	PubMed
41,922,744	ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas.	Nat Metab	2026	https://conductscience.org/library/papers/41922744	PubMed
41,329,526	Oncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer.	J Clin Invest	2026	https://conductscience.org/library/papers/41329526	PubMed
40,699,746	Emerging Tumor Biomarkers in Pancreatic Cancer and Their Clinical Implications.	Curr Issues Mol Biol	2025	https://conductscience.org/library/papers/40699746	PubMed
40,668,540	Differential Control of Growth and Identity by HNF4α Isoforms in Pancreatic Ductal Adenocarcinoma.	Mol Cancer Res	2025	https://conductscience.org/library/papers/40668540	PubMed
40,567,112	The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma.	Adv Sci (Weinh)	2025	https://conductscience.org/library/papers/40567112	PubMed
39,808,248	The Current Role of Circulating Tumor DNA in the Management of Pancreatic Cancer.	J Gastrointest Cancer	2025	https://conductscience.org/library/papers/39808248	PubMed

1 to 10 of 62

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
EGFR	1,956	PubTator's text mining	https://conductscience.org/library/genes/1956	NCBI Gene
GATA6	2,627	PubTator's text mining	https://conductscience.org/library/genes/2627	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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