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Paper · 2653790

Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.

O'Brien JJ and 1 other. Drugs, 1989. Cited by 265 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Papers, record 2653790. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2653790

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.
PubMed
Journal
Drugs
PubMed
Year
1989
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
265
iCite
Relative citation ratio, by iCite
9.29
iCite
Revised in PubMed
2026-10-11
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1O'Brien JJJ J
2Campoli-Richards DMD M

Source PubMed

Topics4

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AcyclovirMajor topic
Virus DiseasesMajor topic
Animals
Humans

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT04988646Pharmacokinetic Properties of 200 and 400 mg Acyclovir Tablet in Indonesia Healthy SubjectResults

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References350

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
12,845,160Acyclovir suppression of frequently recurring genital herpes. Efficacy and diminishing need during successive years of treatment.JAMA1988https://conductscience.org/library/papers/2845160PubMed
23,301,980Oral acyclovir and herpes labialis: a randomized, double-blind, placebo-controlled study.J Am Dent Assoc1987https://conductscience.org/library/papers/3301980PubMed
33,001,523Treatment of varicella-zoster virus infection in severely immunocompromised patients. A randomized comparison of acyclovir and vidarabine.N Engl J Med1986https://conductscience.org/library/papers/3001523PubMed
42,860,316Acyclovir in herpes zoster oticus.Lancet1985https://conductscience.org/library/papers/2860316PubMed
53,722,509Oral acyclovir for the prevention of herpes-associated erythema multiforme.J Am Acad Dermatol1986https://conductscience.org/library/papers/3722509PubMed
62,996,346Infectious complications in heart-lung transplant recipients.Am J Med1985https://conductscience.org/library/papers/2996346PubMed
76,096,237Effects of acyclovir on herpes virus infection and susceptibility of isolated virus to acyclovir.Fukushima J Med Sci1984https://conductscience.org/library/papers/6096237PubMed
86,732,224Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir.Antimicrob Agents Chemother1984https://conductscience.org/library/papers/6732224PubMed
96,315,331Resistance of herpes simplex virus to antiviral agents. Is it clinically important?Drugs1983https://conductscience.org/library/papers/6315331PubMed
103,908,504Topical acyclovir treatment of herpes zoster in immunocompromised patients.J Am Acad Dermatol1985https://conductscience.org/library/papers/3908504PubMed

1 to 10 of 350

See all 350 references

Cited by93

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 265 citations.

PMIDTitleJournalYearIn PapersSource
42,446,5351,3-Dioxolane derived nucleos(t)ides: synthetic strategies, current position, and future promise in antiviral and anticancer drug discovery.Med Chem Res2026https://conductscience.org/library/papers/42446535PubMed
42,074,011Carrageenan-Acyclovir Complex and Its Liposomal Form.Int J Mol Sci2026https://conductscience.org/library/papers/42074011PubMed
41,735,249Antiviral drug discovery and development: challenges and future directions.Signal Transduct Target Ther2026https://conductscience.org/library/papers/41735249PubMed
40,971,810Epstein-Barr virus and spontaneous lymphoblastoid cell lines: establishment, molecular characteristics, immune modulation, and therapeutic insight.Clin Exp Immunol2025https://conductscience.org/library/papers/40971810PubMed
40,943,411Topical and Systemic Therapeutic Approaches in the Treatment of Oral Herpes Simplex Virus Infection: A Systematic Review.Int J Mol Sci2025https://conductscience.org/library/papers/40943411PubMed
40,875,533Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators.FEBS J2026https://conductscience.org/library/papers/40875533PubMed
40,050,867Antiviral treatment for viral pneumonia: current drugs and natural compounds.Virol J2025https://conductscience.org/library/papers/40050867PubMed
39,858,911Decitabine Increases the Transcription of RIG-I Gene to Suppress the Replication of Feline Calicivirus and Canine Influenza Virus.Microorganisms2025https://conductscience.org/library/papers/39858911PubMed
39,554,450Study of Hydrolysis Kinetics and Synthesis of Single Isomer of Phosphoramidate ProTide-Acyclovir.ACS Omega2024https://conductscience.org/library/papers/39554450PubMed
39,412,404Glyoxal Caging of Nucleoside Antivirals toward Self-Activating, Extended-Release Prodrugs.J Am Chem Soc2024https://conductscience.org/library/papers/39412404PubMed

1 to 10 of 93

See all 93 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs1

The drugs whose trials, in the Pipelines release, list the paper.

DrugChEMBL IDThe trials list it asTrialsIn Drugs and targets
ACYCLOVIRCHEMBL184Results1https://conductscience.org/library/drugs/CHEMBL184

Source ChEMBL

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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