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Paper · 6315331

Resistance of herpes simplex virus to antiviral agents. Is it clinically important?

Crumpacker C. Drugs, 1983. Cited by 18 papers, by iCite.

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ConductScience Library. Resistance of herpes simplex virus to antiviral agents. Is it clinically important? Papers, record 6315331. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6315331

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Resistance of herpes simplex virus to antiviral agents. Is it clinically important?
PubMed
Journal
Drugs
PubMed
Year
1983
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
18
iCite
Relative citation ratio, by iCite
0.89
iCite
Revised in PubMed
2018-11-13
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Crumpacker CC

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AcyclovirMajor topic
SimplexvirusMajor topic
Animals
Antiviral Agents
Drug Resistance, Microbial
Herpes Simplex
Humans
Thymidine Kinase

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,247,969Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo.Antimicrob Agents Chemother1980https://conductscience.org/library/papers/6247969PubMed
26,256,650Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance.Nature1981https://conductscience.org/library/papers/6256650PubMed
36,290,575Pathogenicity of acyclovir-resistant herpes simplex virus type 1 from an immunodeficient child.J Infect Dis1982https://conductscience.org/library/papers/6290575PubMed
46,826,696Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses.J Clin Microbiol1983https://conductscience.org/library/papers/6826696PubMed
5229,629Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.Virology1979https://conductscience.org/library/papers/229629PubMed
66,247,818Physical and genetic analysis of the herpes simplex virus DNA polymerase locus.Virology1980https://conductscience.org/library/papers/6247818PubMed
7232,189Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.J Virol1979https://conductscience.org/library/papers/232189PubMed
86,296,119Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase.J Biol Chem1983https://conductscience.org/library/papers/6296119PubMed
96,284,981Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.J Virol1982https://conductscience.org/library/papers/6284981PubMed
106,246,532Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6246532PubMed

1 to 10 of 30

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Cited by4

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 18 citations.

PMIDTitleJournalYearIn PapersSource
21,263,803Genital herpes.Can Fam Physician1987https://conductscience.org/library/papers/21263803PubMed
3,002,245Drug resistance patterns of herpes simplex virus isolates from patients treated with acyclovir.Antimicrob Agents Chemother1985https://conductscience.org/library/papers/3002245PubMed
2,653,790Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.Drugs1989https://conductscience.org/library/papers/2653790PubMed
2,168,202Antiviral drug sensitivity in ocular herpes simplex virus infection.Br J Ophthalmol1990https://conductscience.org/library/papers/2168202PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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