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Paper · 268654

Authentic beta-globin mRNA sequences in homozygous betaO-thalassemia.

Temple GF and 2 others. Proc Natl Acad Sci U S A, 1977. Cited by 80 papers, by iCite.

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ConductScience Library. Authentic beta-globin mRNA sequences in homozygous betaO-thalassemia. Papers, record 268654. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/268654

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Authentic beta-globin mRNA sequences in homozygous betaO-thalassemia.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
80
iCite
Relative citation ratio, by iCite
1.76
iCite
Revised in PubMed
2019-05-01
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Temple GFG F
2Chang JCJ C
3Kan YWY W

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
RNA, MessengerMajor topic
ThalassemiaMajor topic
Adult
Base Sequence
Genes
Globins
Homozygote
Humans
Male
Poly A

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1788,836Molecular basis of thalassaemia.Br Med Bull1976https://conductscience.org/library/papers/788836PubMed
2402,264Studies on the sequence of the 3'-terminal region of turnip-yellow-mosaic-virus RNA.Eur J Biochem1977https://conductscience.org/library/papers/402264PubMed
3265,521A new method for sequencing DNA.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/265521PubMed
4985,635Abnormal or absent beta mRNA in betao Ferrara and gene deletion in delta beta thalassaemia.Nature1976https://conductscience.org/library/papers/985635PubMed
54,611,306Nucleotide sequences of human globin messenger RNA.Ann N Y Acad Sci1974https://conductscience.org/library/papers/4611306PubMed
64,504,350Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4504350PubMed
74,334,193In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA.Nat New Biol1972https://conductscience.org/library/papers/4334193PubMed
84,124,307Decreased globin messenger RNA in thalassemia detected by molecular hybridization.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4124307PubMed
94,124,305Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4124305PubMed
104,817,859Absence of messenger RNA for beta globin chain in beta(0) thalassaemia.Nature1974https://conductscience.org/library/papers/4817859PubMed

1 to 10 of 30

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Cited by28

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 80 citations.

PMIDTitleJournalYearIn PapersSource
9,359,436Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin.Biochem J1997https://conductscience.org/library/papers/9359436PubMed
9,128,242Structural protein 4.1 in the nucleus of human cells: dynamic rearrangements during cell division.J Cell Biol1997https://conductscience.org/library/papers/9128242PubMed
8,423,235An isoform-specific mutation in the protein 4.1 gene results in hereditary elliptocytosis and complete deficiency of protein 4.1 in erythrocytes but not in nonerythroid cells.J Clin Invest1993https://conductscience.org/library/papers/8423235PubMed
8,423,229Differentiation-associated switches in protein 4.1 expression. Synthesis of multiple structural isoforms during normal human erythropoiesis.J Clin Invest1993https://conductscience.org/library/papers/8423229PubMed
8,064,876Investigation of the human Rh blood group system in nonhuman primates and other species with serologic and Southern blot analysis.J Mol Evol1994https://conductscience.org/library/papers/8064876PubMed
7,919,657Molecular cloning of mouse erythrocyte protein 4.2: a membrane protein with strong homology with the transglutaminase supergene family.Mamm Genome1994https://conductscience.org/library/papers/7919657PubMed
6,894,931Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics.J Clin Invest1981https://conductscience.org/library/papers/6894931PubMed
6,826,718alpha-Thalassemia caused by an unstable alpha-globin mutant.J Clin Invest1983https://conductscience.org/library/papers/6826718PubMed
6,689,503Structural and evolutionary analysis of the two chimpanzee alpha-globin mRNAs.Nucleic Acids Res1983https://conductscience.org/library/papers/6689503PubMed
6,457,059beta zero thalassemia in Sardinia is caused by a nonsense mutation.J Clin Invest1981https://conductscience.org/library/papers/6457059PubMed

1 to 10 of 28

See all 28 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
HBB3,043PubTator's text mininghttps://conductscience.org/library/genes/3043

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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