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Paper271995

Antigen-binding mutants of mouse myeloma cells.

Cook WD and 1 other. Proc Natl Acad Sci U S A, 1977. Cited by 76 papers, by iCite.

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ConductScience Library. Antigen-binding mutants of mouse myeloma cells. Papers, record 271995. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/271995

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Antigen-binding mutants of mouse myeloma cells.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
76
iCite
Relative citation ratio, by iCite
1.46
iCite
Revised in PubMed
2019-05-01
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Cook WDW D
2Scharff MDM D

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibody SpecificityMajor topic
Binding Sites, AntibodyMajor topic
Immunoglobulin AMajor topic
Myeloma ProteinsMajor topic
Antigen-Antibody Reactions
Carrier Proteins
Cell Line
Hemocyanins
Mutation
Phosphorylcholine

Source PubMed

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1401,950Molecular analysis of spontaneous somatic mutants.Nature1977https://conductscience.org/library/papers/401950PubMed
2827,496Structural basis for the specificity of phosphorylcholine-binding immunoglobulins.Immunochemistry1976https://conductscience.org/library/papers/827496PubMed
3825,377Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion.Eur J Immunol1976https://conductscience.org/library/papers/825377PubMed
41,086,883Allogeneic carrier-specific enhancement of hapten-specific secondary B-cell responses.J Exp Med1976https://conductscience.org/library/papers/1086883PubMed
54,139,712Variants of mouse myeloma cells that produce short immunoglobulin heavy chains.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4139712PubMed
64,137,581Clonal nature of the immune response to phosphorylcholine. IV. Idiotypic uniformity of binding site-associated antigenic determinants among mouse antiphosphorylcholine antibodies.J Exp Med1974https://conductscience.org/library/papers/4137581PubMed
74,140,089Affinity labeling and topology of the antibody combining site.Essays Biochem1974https://conductscience.org/library/papers/4140089PubMed
84,128,217Mutagenesis of mouse myeloma cells with 'Melphalan'.Nature1973https://conductscience.org/library/papers/4128217PubMed
94,101,363Common individual antigenic determinants in five of eight BALB-c IgA myeloma proteins that bind phosphoryl choline.J Exp Med1970https://conductscience.org/library/papers/4101363PubMed
104,173,394Studies on the structure of mouse gamma-A myeloma proteins.Biochemistry1968https://conductscience.org/library/papers/4173394PubMed
114,180,087Characterization of the antibody to the C-carbohydrate produced by a transplantable mouse plasmacytoma.Immunochemistry1969https://conductscience.org/library/papers/4180087PubMed
124,189,836Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor-11 to culture, cloning, and characterization of gamma globulin subunits.J Exp Med1970https://conductscience.org/library/papers/4189836PubMed
134,354,174Mutations in immunoglobulin-producing mouse myeloma cells.Science1973https://conductscience.org/library/papers/4354174PubMed
144,625,122Cloning of mouse myeloma cells and detection of rare variants.J Cell Physiol1972https://conductscience.org/library/papers/4625122PubMed
1546,246Specific isolation and characterization of antibody directed to binding site antigenic determinants.J Immunol1975https://conductscience.org/library/papers/46246PubMed
164,555,516Immunoglobulin-producing tumors and myeloma proteins of mice.Physiol Rev1972https://conductscience.org/library/papers/4555516PubMed
174,530,984The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4530984PubMed
184,472,818Chemical characterization of a mouse immunoglobulin A heavy chain with a 100-residue deletion. Amino acid and carbohydrate compositions and NH2-and COOH-terminal sequences.J Biol Chem1974https://conductscience.org/library/papers/4472818PubMed
195,059,886Affinity labeling of a phosphorylcholine binding mouse myeloma protein.Biochemistry1972https://conductscience.org/library/papers/5059886PubMed
205,037,438Growth of primary plasmacytomas in the mineral oil-conditioned peritoneal environment.J Natl Cancer Inst1972https://conductscience.org/library/papers/5037438PubMed

See all 28 references

Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 76 citations.

PMIDTitleJournalYearIn PapersSource
34,661,773Hybridoma technology; advancements, clinical significance, and future aspects.J Genet Eng Biotechnol2021https://conductscience.org/library/papers/34661773PubMed
19,564,341Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis.J Immunol2009https://conductscience.org/library/papers/19564341PubMed
18,449,194Rapid cloning of high-affinity human monoclonal antibodies against influenza virus.Nature2008https://conductscience.org/library/papers/18449194PubMed
8,654,371Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines.EMBO J1996https://conductscience.org/library/papers/8654371PubMed
7,708,729A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.Proc Natl Acad Sci U S A1995https://conductscience.org/library/papers/7708729PubMed
7,485,402Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.Am J Pathol1995https://conductscience.org/library/papers/7485402PubMed
7,299,348Somatically generated mouse myeloma variants synthesizing IgA half-molecules.J Exp Med1981https://conductscience.org/library/papers/7299348PubMed
6,976,303Present status and future prospects for the hybridoma technology.In Vitro1981https://conductscience.org/library/papers/6976303PubMed
6,817,080Mutations affecting the structure and function of immunoglobulin M.Mol Cell Biol1982https://conductscience.org/library/papers/6817080PubMed
6,804,947Single amino acid substitution altering antigen-binding specificity.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6804947PubMed
6,803,237Somatic mutation in a cultured mouse myeloma cell affects antigen binding.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6803237PubMed
6,788,890Nucleic acid and protein sequences of phosphocholine-binding light chains.J Exp Med1981https://conductscience.org/library/papers/6788890PubMed
6,765,233Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity.EMBO J1982https://conductscience.org/library/papers/6765233PubMed
6,544,903Different ways to modify monoclonal antibodies.Med Oncol Tumor Pharmacother1984https://conductscience.org/library/papers/6544903PubMed
6,435,121Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6435121PubMed
6,360,156Mutations that influence the secretory path in animal cells.Biochem J1983https://conductscience.org/library/papers/6360156PubMed
6,253,904Cloning and sequence of the cDNA corresponding to the variable region of immunoglobulin heavy chain MPC11.Nucleic Acids Res1980https://conductscience.org/library/papers/6253904PubMed
6,203,114Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6203114PubMed
3,928,369Derivation and diversification of monoclonal antibodies.EMBO J1985https://conductscience.org/library/papers/3928369PubMed
3,472,207Immunoglobulin A stimulates growth of the extrahepatic bile duct in BALB/c mice.Proc Natl Acad Sci U S A1987https://conductscience.org/library/papers/3472207PubMed

See all 27 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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  • PMC's ID filePublic domain (US government)
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  • PubTator 3Public domain
  • UniProtCC BY 4.0
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  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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