Paper27353

The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets.

Malaisse WJ and 3 others. Eur J Biochem, 1978. Cited by 141 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets. Papers, record 27353. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/27353

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets.; PubMed
Journal: Eur J Biochem; PubMed
Year: 1978; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/27353/; PubMed
DOI: https://doi.org/10.1111/j.1432-1033.1978.tb12357.x; PubMed
The journal: https://conductscience.org/library/journal-index/0107600; PubMed
Citations, by iCite: 141; iCite
Relative citation ratio, by iCite: 4.97; iCite
Revised in PubMed: 2019-06-20; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Malaisse WJ	W J
2	Hutton JC	J C
3	Kawazu S	S
4	Sener A	A

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Islets of Langerhans	Major topic
Vitamin K	Major topic
Adenine Nucleotides
Animals
Calcium
Female
Glucose
Glycolysis
In Vitro Techniques
NAD
NADP
Oxidation-Reduction
Pentosephosphates
Proinsulin
Rats

Source PubMed

Show 9 more topicsShow fewer topics

Cited by38

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 141 citations.

PMID	Title	Journal	Year	In Papers	Source
37,600,713	A pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell.	Front Endocrinol (Lausanne)	2023	https://conductscience.org/library/papers/37600713	PubMed
22,115,979	The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion.	Toxicol Appl Pharmacol	2012	https://conductscience.org/library/papers/22115979	PubMed
17,960,358	Fuel-induced amplification of insulin secretion in mouse pancreatic islets exposed to a high sulfonylurea concentration: role of the NADPH/NADP+ ratio.	Diabetologia	2008	https://conductscience.org/library/papers/17960358	PubMed
15,181,163	Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal.	J Physiol	2004	https://conductscience.org/library/papers/15181163	PubMed
9,350,043	Subcellular distribution of hexokinase isoenzymes in pancreatic islet cells exposed to digitonin after incubation at a low or high concentration of D-glucose.	Mol Cell Biochem	1997	https://conductscience.org/library/papers/9350043	PubMed
7,753,041	Hexose metabolism in pancreatic islets: effect of D-glucose on the mitochondrial redox state.	Mol Cell Biochem	1995	https://conductscience.org/library/papers/7753041	PubMed
7,046,729	The stimulus-secretion coupling of glucose-induced insulin release. Environmental influences on L-glutamine oxidation in pancreatic islets.	Biochem J	1982	https://conductscience.org/library/papers/7046729	PubMed
7,038,690	Determinants of the selective toxicity of alloxan to the pancreatic B cell.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/7038690	PubMed
7,021,285	The stimulus-secretion coupling of amino acid-induced insulin release. Biosynthetic and secretory responses of rat pancreatic islet to L-leucine and L-glutamine.	Diabetologia	1981	https://conductscience.org/library/papers/7021285	PubMed
7,004,965	The stimulus-secretion coupling in glucose-induced insulin release xliv. A possible link between glucose metabolism and phosphate flush.	Diabetologia	1980	https://conductscience.org/library/papers/7004965	PubMed
6,998,242	Evidence for a limited role of NAD(P)H in the nutritional regulation of glucagon release: studies with menadione and NH4Cl.	Acta Diabetol Lat	1980	https://conductscience.org/library/papers/6998242	PubMed
6,995,864	Metabolic, cationic and secretory effects of hypoglycemic sulfonylureas in pancreatic islets.	Naunyn Schmiedebergs Arch Pharmacol	1980	https://conductscience.org/library/papers/6995864	PubMed
6,436,051	Phospholipid metabolism in pancreatic islets.	Experientia	1984	https://conductscience.org/library/papers/6436051	PubMed
6,409,083	Mechanism of 3-phenylpyruvate-induced insulin release. Metabolic aspects.	Biochem J	1983	https://conductscience.org/library/papers/6409083	PubMed
6,388,570	Hexose metabolism in pancreatic islets. Inhibition of hexokinase.	Biochem J	1984	https://conductscience.org/library/papers/6388570	PubMed
6,378,186	The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state.	Biochem J	1984	https://conductscience.org/library/papers/6378186	PubMed
6,347,184	Mechanism of 3-phenylpyruvate-induced insulin release. Secretory, ionic and oxidative aspects.	Biochem J	1983	https://conductscience.org/library/papers/6347184	PubMed
6,344,863	Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate.	Biochem J	1983	https://conductscience.org/library/papers/6344863	PubMed
6,245,006	Glucoreceptor mechanisms and the control of insulin release and biosynthesis.	Diabetologia	1980	https://conductscience.org/library/papers/6245006	PubMed
6,237,930	Nutrient metabolism in islet cells.	Experientia	1984	https://conductscience.org/library/papers/6237930	PubMed

Show 14 more cited byShow fewer cited bySee all 38 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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