Paper · 27536734

Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics.

Mo CY and 7 others. mSphere, 2016. Cited by 71 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics. Papers, record 27536734. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/27536734

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics.; PubMed
Journal: mSphere; PubMed
Year: 2016; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/27536734/; PubMed
DOI: https://doi.org/10.1128/msphere.00163-16; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4980697/; PubMed
The journal: https://conductscience.org/library/journal-index/101674533; PubMed
Citations, by iCite: 71; iCite
Relative citation ratio, by iCite: 2.66; iCite
Revised in PubMed: 2025-05-30; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Mo CY	Charlie Y
2	Manning SA	Sara A
3	Roggiani M	Manuela
4	Culyba MJ	Matthew J
5	Samuels AN	Amanda N
6	Sniegowski PD	Paul D
7	Goulian M	Mark
8	Kohli RM	Rahul M

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
T32 AI070077	NIAID NIH HHS	United States	T32AI070077	PubMed	NIH RePORTER
T32 GM007229	NIGMS NIH HHS	United States	T32GM007229	PubMed and NIH	NIH RePORTER
T32 AR007442	NIAMS NIH HHS	United States	T32AR007442	PubMed and NIH	NIH RePORTER
2012071	Doris Duke Charitable Foundation	United States		PubMed	PubMed
DP2 GM105444	NIGMS NIH HHS	United States	DP2GM105444	PubMed and NIH	NIH RePORTER
			R01GM080279	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References74

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,780,917	Expression of the E. coli uvrA gene is inducible.	Nature	1981	https://conductscience.org/library/papers/6780917	PubMed
2	21,264,289	Rapid and highly efficient method for scarless mutagenesis within the Salmonella enterica chromosome.	PLoS One	2011	https://conductscience.org/library/papers/21264289	PubMed
3	17,883,408	Aeons of distress: an evolutionary perspective on the bacterial SOS response.	FEMS Microbiol Rev	2007	https://conductscience.org/library/papers/17883408	PubMed
4	18,497,818	Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.	Nature	2008	https://conductscience.org/library/papers/18497818	PubMed
5	19,556,999	The SOS response promotes qnrB quinolone-resistance determinant expression.	EMBO Rep	2009	https://conductscience.org/library/papers/19556999	PubMed
6	23,224,554	Identity and function of a large gene network underlying mutagenic repair of DNA breaks.	Science	2012	https://conductscience.org/library/papers/23224554	PubMed
7	18,832,356	A simple formula for obtaining markedly improved mutation rate estimates.	Genetics	2008	https://conductscience.org/library/papers/18832356	PubMed
8	795,416	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	Bacteriol Rev	1976	https://conductscience.org/library/papers/795416	PubMed
9	4,343,824	Dominant mutations (lex) in Escherichia coli K-12 which affect radiation sensitivity and frequency of ultraviolet lght-induced mutations.	J Bacteriol	1972	https://conductscience.org/library/papers/4343824	PubMed
10	6,087,326	Cell-division control in Escherichia coli: specific induction of the SOS function SfiA protein is sufficient to block septation.	Proc Natl Acad Sci U S A	1984	https://conductscience.org/library/papers/6087326	PubMed

1 to 10 of 74

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Cited by45

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 71 citations.

PMID	Title	Journal	Year	In Papers	Source
42,243,332	Inhibition of the SOS response by olivetol improves the efficacy of DNA-damaging antibiotics in Escherichia coli.	J Antibiot (Tokyo)	2026	https://conductscience.org/library/papers/42243332	PubMed
41,387,400	Stress-induced toxic genomic R-loops support biofilm extracellular matrix formation.	Nat Commun	2025	https://conductscience.org/library/papers/41387400	PubMed
41,201,096	Identification and Characterization of a Small-Molecule Inhibitor of the Pseudomonas aeruginosa SOS Response.	ACS Infect Dis	2025	https://conductscience.org/library/papers/41201096	PubMed
41,145,705	Suppression of bacterial cell death underlies the antagonistic interaction between ciprofloxacin and tetracycline.	Mol Syst Biol	2026	https://conductscience.org/library/papers/41145705	PubMed
40,434,128	Mechanistic divergence between SOS response activation and antibiotic-induced plasmid conjugation in Escherichia coli.	Microbiol Spectr	2025	https://conductscience.org/library/papers/40434128	PubMed
39,964,597	Unravelling the Antibiotic Resistance: Molecular Insights and Combating Therapies.	Appl Biochem Biotechnol	2025	https://conductscience.org/library/papers/39964597	PubMed
39,697,181	Cyclic di-AMP regulates genome stability and drug resistance in Mycobacterium through RecA-dependent and RecA-independent recombination.	PNAS Nexus	2024	https://conductscience.org/library/papers/39697181	PubMed
39,589,140	Insights into antibiotic resistance promoted by quinolone exposure.	Antimicrob Agents Chemother	2025	https://conductscience.org/library/papers/39589140	PubMed
39,359,682	Staphylococcus aureus SOS response: Activation, impact, and drug targets.	mLife	2024	https://conductscience.org/library/papers/39359682	PubMed
38,596,376	SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated.	Front Microbiol	2024	https://conductscience.org/library/papers/38596376	PubMed

1 to 10 of 45

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Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
DNAH8	1,769	PubTator's text mining	https://conductscience.org/library/genes/1769	NCBI Gene
RAD51	5,888	PubTator's text mining	https://conductscience.org/library/genes/5888	NCBI Gene
XYLT2	64,132	PubTator's text mining	https://conductscience.org/library/genes/64132	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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