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Paper · 286311

Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.

Huberman E and 1 other. Proc Natl Acad Sci U S A, 1979. Cited by 622 papers, by iCite.

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ConductScience Library. Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents. Papers, record 286311. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/286311

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
622
iCite
Relative citation ratio, by iCite
14.5
iCite
Revised in PubMed
2019-05-01
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Huberman EE
2Callaham MFM F

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell DifferentiationMajor topic
Leukemia, MyeloidMajor topic
Phorbol EstersMajor topic
PhorbolsMajor topic
Cell Division
Cell Line
Humans
Kinetics
Phagocytosis
Structure-Activity Relationship

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1268,640Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/268640PubMed
2269,404Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/269404PubMed
3308,698Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors.Science1978https://conductscience.org/library/papers/308698PubMed
463,324Absence of thymus-derived lymphocyte markers in myelogenous leukemia (Ph1+) cell line K-562.Cancer Res1976https://conductscience.org/library/papers/63324PubMed
5276,884Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/276884PubMed
6271,272Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture.Nature1977https://conductscience.org/library/papers/271272PubMed
7679,198Rapid stimulation of phospholipid metabolism in bovine lymphocytes by tumor-promoting phorbol esters.Cancer Res1978https://conductscience.org/library/papers/679198PubMed
8683,306Opposing effects of tumor promoters on erythroid differentiation.Nature1978https://conductscience.org/library/papers/683306PubMed
9644,318Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells.Science1978https://conductscience.org/library/papers/644318PubMed
10593,321Inhibition of adipose conversion of 3T3 fibroblasts by tumour promoters.Nature1977https://conductscience.org/library/papers/593321PubMed

1 to 10 of 24

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Cited by88

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 622 citations.

PMIDTitleJournalYearIn PapersSource
35,661,925Anti-cancer activities of Schedule E1 drugs used in ayurvedic formulations.J Ayurveda Integr Med2022https://conductscience.org/library/papers/35661925PubMed
30,764,849SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia.J Exp Clin Cancer Res2019https://conductscience.org/library/papers/30764849PubMed
28,589,317Bcl6 gene-silencing facilitates PMA-induced megakaryocyte differentiation in K562 cells.J Cell Commun Signal2017https://conductscience.org/library/papers/28589317PubMed
27,490,470Effective Cellular Morphology Analysis for Differentiation Processes by a Fluorescent 1,3a,6a-Triazapentalene Derivative Probe in Live Cells.PLoS One2016https://conductscience.org/library/papers/27490470PubMed
27,079,536Characterization of the 5'-flanking region of the human DNA helicase B (HELB) gene and its response to trans-Resveratrol.Sci Rep2016https://conductscience.org/library/papers/27079536PubMed
24,855,377
Transcriptional targeting of sphingosine-1-phosphate receptor S1P2 by epigallocatechin-3-gallate prevents sphingosine-1-phosphate-mediated signaling in macrophage-differentiated HL-60 promyelomonocytic leukemia cells.
Onco Targets Ther2014https://conductscience.org/library/papers/24855377PubMed
22,707,304EGCG targeting efficacy of NF-κB downstream gene products is dictated by the monocytic/macrophagic differentiation status of promyelocytic leukemia cells.Cancer Immunol Immunother2012https://conductscience.org/library/papers/22707304PubMed
22,359,111Characteristics of U-937 and HL-60 leukemia cells differentiated by spinach extract.Cytotechnology1994https://conductscience.org/library/papers/22359111PubMed
22,043,318Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils.PLoS One2011https://conductscience.org/library/papers/22043318PubMed
21,461,879The possible functions of duplicated ets (GGAA) motifs located near transcription start sites of various human genes.Cell Mol Life Sci2011https://conductscience.org/library/papers/21461879PubMed

1 to 10 of 88

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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