Paper · 29263147

Phenylalanine regulates initiation of digestive enzyme mRNA translation in pancreatic acinar cells and tissue segments in dairy calves.

Guo L and 7 others. Biosci Rep, 2018. Cited by 24 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Phenylalanine regulates initiation of digestive enzyme mRNA translation in pancreatic acinar cells and tissue segments in dairy calves. Papers, record 29263147. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29263147

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Phenylalanine regulates initiation of digestive enzyme mRNA translation in pancreatic acinar cells and tissue segments in dairy calves.; PubMed
Journal: Biosci Rep; PubMed
Year: 2018; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/29263147/; PubMed
DOI: https://doi.org/10.1042/bsr20171189; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5784178/; PubMed
The journal: https://conductscience.org/library/journal-index/8102797; PubMed
Citations, by iCite: 24; iCite
Relative citation ratio, by iCite: 1.3; iCite
Revised in PubMed: 2018-11-13; PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Guo L	Long
2	Tian H	Huibin
3	Shen J	Jing
4	Zheng C	Chen
5	Liu S	Shimin
6	Cao Y	Yangchun
7	Cai C	Chuanjiang
8	Yao J	Junhu

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Acinar Cells	Major topic
Pancreas	Major topic
Phenylalanine	Major topic
Protein Biosynthesis	Major topic
Animals
Cattle
Epithelial Cells
Gene Expression Regulation, Enzymologic
Lipase
Phosphorylation
Primary Cell Culture
Ribosomal Protein S6 Kinases
Signal Transduction
Trypsin
alpha-Amylases

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References46

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	970,448	Canine gut receptors mediating pancreatic responses to luminal L-amino acids.	Am J Physiol	1976	https://conductscience.org/library/papers/970448	PubMed
2	11,790,952	Control of protein synthesis by amino acid availability.	Curr Opin Clin Nutr Metab Care	2002	https://conductscience.org/library/papers/11790952	PubMed
3	14,684,179	Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids.	Biochem Biophys Res Commun	2004	https://conductscience.org/library/papers/14684179	PubMed
4	9,218,810	Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.	EMBO J	1997	https://conductscience.org/library/papers/9218810	PubMed
5	25,373,594	Phenylalanine sensitive K562-D cells for the analysis of the biochemical impact of excess amino acid.	Sci Rep	2014	https://conductscience.org/library/papers/25373594	PubMed
6	4,809,890	Molecular regulation of digestion: short term and bond specific.	Am J Physiol	1974	https://conductscience.org/library/papers/4809890	PubMed
7	2,420,368	Digestive end products release pancreatic enzymes from particulate cellular pools, particularly zymogen granules.	Biochim Biophys Acta	1986	https://conductscience.org/library/papers/2420368	PubMed
8	1,370,326	Dietary influences on carbohydrases and small intestinal starch hydrolysis capacity in ruminants.	J Nutr	1992	https://conductscience.org/library/papers/1370326	PubMed
9	10,659,969	Effects of insulin and postruminal supply of protein on use of amino acids by the mammary gland for milk protein synthesis.	J Dairy Sci	2000	https://conductscience.org/library/papers/10659969	PubMed
10	16,286,006	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	Cell	2005	https://conductscience.org/library/papers/16286006	PubMed

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 24 citations.

PMID	Title	Journal	Year	In Papers	Source
42,497,073	DNAJC12 Stabilizes Phenylalanine Hydroxylase and Facilitates Its Substrate-Dependent Activation.	FASEB J	2026	https://conductscience.org/library/papers/42497073	PubMed
42,292,855	Increased Brown Adipose Tissue Thermogenesis in Phenylketonuria.	MedComm (2020)	2026	https://conductscience.org/library/papers/42292855	PubMed
39,684,845	Phenylalanine Regulates Milk Protein Synthesis via LAT1-mTOR Signaling Pathways in Bovine Mammary Epithelial Cells.	Int J Mol Sci	2024	https://conductscience.org/library/papers/39684845	PubMed
38,770,669	Disrupted one-carbon metabolism in heifers negatively affects their health and physiology.	J Anim Sci	2024	https://conductscience.org/library/papers/38770669	PubMed
38,027,945	Effects of soda water on blood lipid and metabolic profiling of urine in hyperlipidemia rats using UPLC/Triple-TOF MS.	Heliyon	2023	https://conductscience.org/library/papers/38027945	PubMed
36,108,692	Effects of dandelion (Taraxacum sp.,) supplements on lactation performance, antioxidative activity, and plasma metabolome in primiparous dairy cows.	Anim Biosci	2023	https://conductscience.org/library/papers/36108692	PubMed
35,431,492	Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis.	World J Gastroenterol	2022	https://conductscience.org/library/papers/35431492	PubMed
34,754,956	Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more.	Anim Nutr	2021	https://conductscience.org/library/papers/34754956	PubMed
33,450,809	Prenatal and Postnatal Nutrition Influence Pancreatic and Intestinal Carbohydrase Activities of Ruminants.	Animals (Basel)	2021	https://conductscience.org/library/papers/33450809	PubMed
31,879,771	Effects of Nutrient Restriction During Midgestation to Late Gestation on Maternal and Fetal Postruminal Carbohydrase Activities in Sheep.	J Anim Sci	2020	https://conductscience.org/library/papers/31879771	PubMed

1 to 10 of 13

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
RPS6KB1	6,198	PubTator's text mining	https://conductscience.org/library/genes/6198

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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