Paper · 29856367
Gene therapy and genome surgery in the retina.
DiCarlo JE and 2 others. J Clin Invest, 2018. Cited by 111 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. Gene therapy and genome surgery in the retina. Papers, record 29856367. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29856367
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Publication types
- Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
- PubMed
Topics6
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| CRISPR-Cas Systems | Major topic |
| Gene Editing | Major topic |
| Genetic Therapy | Major topic |
| Retinal Diseases | Major topic |
| Animals | |
| Humans |
Source PubMed
Grants9
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| R21 AG050437 | NIA NIH HHS | United States | R21AG050437 | PubMed and NIH | NIH RePORTER |
| R01 EY018213 | NEI NIH HHS | United States | R01EY018213 | PubMed and NIH | NIH RePORTER |
| P30 EY026877 | NEI NIH HHS | United States | P30EY026877 | PubMed and NIH | NIH RePORTER |
| R01 EY024665 | NEI NIH HHS | United States | R01EY024665 | PubMed and NIH | NIH RePORTER |
| R01 EY026682 | NEI NIH HHS | United States | R01EY026682 | PubMed and NIH | NIH RePORTER |
| R01 EY024698 | NEI NIH HHS | United States | R01EY024698 | PubMed and NIH | NIH RePORTER |
| P30 EY019007 | NEI NIH HHS | United States | P30EY019007 | PubMed and NIH | NIH RePORTER |
| R01 EY025225 | NEI NIH HHS | United States | R01EY025225 | PubMed and NIH | NIH RePORTER |
| P30 CA013696 | NCI NIH HHS | United States | P30CA013696 | PubMed and NIH | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References171
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 12,907,141 | AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa. | Mol Ther | 2003 | https://conductscience.org/library/papers/12907141 | PubMed |
| 2 | 26,087,757 | Gene Augmentation Therapy Restores Retinal Function and Visual Behavior in a Sheep Model of CNGA3 Achromatopsia. | Mol Ther | 2015 | https://conductscience.org/library/papers/26087757 | PubMed |
| 3 | 22,623,665 | Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors. | J Neurosci | 2012 | https://conductscience.org/library/papers/22623665 | PubMed |
| 4 | 22,180,149 | Homozygous mutation in MERTK causes severe autosomal recessive retinitis pigmentosa. | Eur J Ophthalmol | 2012 | https://conductscience.org/library/papers/22180149 | PubMed |
| 5 | 20,006,823 | Leber congenital amaurosis: clinical correlations with genotypes, gene therapy trials update, and future directions. | J AAPOS | 2009 | https://conductscience.org/library/papers/20006823 | PubMed |
| 6 | 17,194,735 | An eye's view of T regulatory cells. | J Leukoc Biol | 2007 | https://conductscience.org/library/papers/17194735 | PubMed |
| 7 | 26,825,853 | Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial. | Hum Genet | 2016 | https://conductscience.org/library/papers/26825853 | PubMed |
| 8 | 28,615,319 | Retinoschisin is linked to retinal Na/K-ATPase signaling and localization. | Mol Biol Cell | 2017 | https://conductscience.org/library/papers/28615319 | PubMed |
| 9 | 9,990,021 | The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase. | Proc Natl Acad Sci U S A | 1999 | https://conductscience.org/library/papers/9990021 | PubMed |
| 10 | 28,988,713 | Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation. | Mol Ther | 2018 | https://conductscience.org/library/papers/28988713 | PubMed |
1 to 10 of 171
See all 171 referencesCited by86
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 111 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,329,402 | Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies. | Inflamm Res | 2026 | https://conductscience.org/library/papers/42329402 | PubMed |
| 42,107,518 | Modalities of vision restoration in optic neuropathies and retinal disease. | Prog Retin Eye Res | 2026 | https://conductscience.org/library/papers/42107518 | PubMed |
| 41,914,074 | Phosphatase and tensin homolog: A potential target for therapeutic intervention in optic nerve regeneration. | Neural Regen Res | 2026 | https://conductscience.org/library/papers/41914074 | PubMed |
| 41,828,635 | Precise CRISPR-Mediated Editing of the TGFBI R555W Mutation in Patient-Derived Peripheral Blood Mononuclear Cells. | Int J Mol Sci | 2026 | https://conductscience.org/library/papers/41828635 | PubMed |
| 41,060,148 | Preclinical Evaluation of Pitavastatin Nanoparticles for Preserving Cone Photoreceptors in Mouse Models of RP. | Invest Ophthalmol Vis Sci | 2025 | https://conductscience.org/library/papers/41060148 | PubMed |
| 41,040,161 | RHO1-2 meganuclease gene editing targets human P23H rhodopsin-induced retinitis pigmentosa to rejuvenate rods and maintain cones. | bioRxiv | 2025 | https://conductscience.org/library/papers/41040161 | PubMed |
| 40,654,372 | Advancements in CRISPR/Cas systems for disease treatment. | Acta Pharm Sin B | 2025 | https://conductscience.org/library/papers/40654372 | PubMed |
| 40,573,393 | Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In Vivo. | Viruses | 2025 | https://conductscience.org/library/papers/40573393 | PubMed |
| 40,121,528 | A synthetic opsin restores vision in patients with severe retinal degeneration. | Mol Ther | 2025 | https://conductscience.org/library/papers/40121528 | PubMed |
| 39,693,439 | dCasMINI-mediated therapy rescues photoreceptors degeneration in a mouse model of retinitis pigmentosa. | Sci Adv | 2024 | https://conductscience.org/library/papers/39693439 | PubMed |
1 to 10 of 86
See all 86 cited byGenes3
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| CEP290 | 80,184 | PubTator's text mining | https://conductscience.org/library/genes/80184 | NCBI Gene |
| MERTK | 10,461 | PubTator's text mining | https://conductscience.org/library/genes/10461 | NCBI Gene |
| RPE65 | 6,121 | PubTator's text mining | https://conductscience.org/library/genes/6121 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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