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Paper · 305459

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

Zinkernagel RM and 5 others. J Exp Med, 1978. Cited by 954 papers, by iCite.

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ConductScience Library. On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? Papers, record 305459. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/305459

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
954
iCite
Relative citation ratio, by iCite
16.9
iCite
Revised in PubMed
2019-05-08
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zinkernagel RMR M
2Callahan GNG N
3Althage AA
4Cooper SS
5Klein PAP A
6Klein JJ

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cytotoxicity, ImmunologicMajor topic
H-2 AntigensMajor topic
T-LymphocytesMajor topic
Thymus GlandMajor topic
Animals
Antigens, Viral
Bone Marrow
Cell Differentiation
Mice
Radiation Chimera
Spleen
Vaccinia virus

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
166,784Similarity of idiotypic determinants of T-and B-lymphocyte receptors for alloantigens.Immunol Rev1977https://conductscience.org/library/papers/66784PubMed
262,016H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.J Exp Med1976https://conductscience.org/library/papers/62016PubMed
363,988Two different VH gene products make up the T-cell receptors.Scand J Immunol1976https://conductscience.org/library/papers/63988PubMed
4185,298Characterization of Ia antigens in mouse serum.J Immunol1976https://conductscience.org/library/papers/185298PubMed
5408,419Cell-mediated immune response to lymphocytic choriomeningitis and vaccinia virus in rats.J Immunol1977https://conductscience.org/library/papers/408419PubMed
6331,324Rationale for combined use of fetal liver and thymus for immunological reconstitution in patients with variants of severe combined immunodeficiency.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/331324PubMed
7302,181The role of the histocompatibilty gene complex in lymphocyte defferetiation.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/302181PubMed
8302,178Genetic restriction in T-lymphocyte activation by antigen-pulse peritoneal exudate cells.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/302178PubMed
9302,174The concept that surveillance of self is mediated via the same set of genes that determines recognition of allogenic cells.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/302174PubMed
10300,847Y-antigen killing by T cells of women is restricted by HLA.Nature1977https://conductscience.org/library/papers/300847PubMed

1 to 10 of 33

See all 33 references

Cited by228

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 954 citations.

PMIDTitleJournalYearIn PapersSource
39,362,875Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders.Signal Transduct Target Ther2024https://conductscience.org/library/papers/39362875PubMed
35,877,372Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment.Bioengineering (Basel)2022https://conductscience.org/library/papers/35877372PubMed
32,790,346Glycan-Modified Virus-like Particles Evoke T Helper Type 1-like Immune Responses.ACS Nano2021https://conductscience.org/library/papers/32790346PubMed
30,324,237Thymoproteasome and peptidic self.Immunogenetics2019https://conductscience.org/library/papers/30324237PubMed
24,550,914Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III.Front Immunol2014https://conductscience.org/library/papers/24550914PubMed
24,517,426Transplantation tolerance: from theory to clinic.Immunol Rev2014https://conductscience.org/library/papers/24517426PubMed
23,046,122T cells and their eons-old obsession with MHC.Immunol Rev2012https://conductscience.org/library/papers/23046122PubMed
22,509,425Mixed chimerism and split tolerance: mechanisms and clinical correlations.Chimerism2011https://conductscience.org/library/papers/22509425PubMed
22,345,700Positive selection in the thymus: an enigma wrapped in a mystery.J Immunol2012https://conductscience.org/library/papers/22345700PubMed
21,962,492Evolutionarily conserved features contribute to αβ T cell receptor specificity.Immunity2011https://conductscience.org/library/papers/21962492PubMed

1 to 10 of 228

See all 228 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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