Paper · 62016

H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.

Zinkernagel RM. J Exp Med, 1976. Cited by 76 papers, by iCite.

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ConductScience Library. H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras. Papers, record 62016. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/62016

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.; PubMed
Journal: J Exp Med; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/62016/; PubMed
DOI: https://doi.org/10.1084/jem.144.4.933; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2190437/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 76; iCite
Relative citation ratio, by iCite: 2.02; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Zinkernagel RM	R M

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigens, Viral	Major topic
Histocompatibility Antigens	Major topic
T-Lymphocytes	Major topic
Animals
Cell Membrane
Crosses, Genetic
Cytopathogenic Effect, Viral
Cytotoxicity Tests, Immunologic
Epitopes
Female
Lymphocytic choriomeningitis virus
Male
Mice
Mice, Inbred Strains
Radiation Chimera
Transplantation, Homologous
Vaccinia virus

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,083,955	Virus-specific T-cell-mediated cytotoxicity across the H-2 barrier to virus-altered alloantigen.	Nature	1976	https://conductscience.org/library/papers/1083955	PubMed
2	1,083,956	Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells.	Nature	1976	https://conductscience.org/library/papers/1083956	PubMed
3	1,090,698	Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.	J Exp Med	1975	https://conductscience.org/library/papers/1090698	PubMed
4	14,978,855	The somatic generation of immune recognition.	Eur J Immunol	1971	https://conductscience.org/library/papers/14978855	PubMed
5	185,057	Primary and secondary in vitro generation of cytolytic T lymphocytes in the murine sarcoma virus system.	Eur J Immunol	1975	https://conductscience.org/library/papers/185057	PubMed
6	4,133,807	Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.	Nature	1974	https://conductscience.org/library/papers/4133807	PubMed
7	4,139,235	Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice.	J Exp Med	1974	https://conductscience.org/library/papers/4139235	PubMed
8	4,151,339	Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.	Adv Immunol	1974	https://conductscience.org/library/papers/4151339	PubMed
9	4,275,043	An improved system for the assay of stimulation in mouse mixed leucocyte cultures.	J Immunol Methods	1974	https://conductscience.org/library/papers/4275043	PubMed
10	4,394,377	F1 hybrid animals: reactivity against recognition structures of parental strain lymphoid cells.	Pathol Microbiol (Basel)	1969	https://conductscience.org/library/papers/4394377	PubMed

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Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 76 citations.

PMID	Title	Journal	Year	In Papers	Source
23,230,443	Toward a molecular understanding of adaptive immunity: a chronology, part I.	Front Immunol	2012	https://conductscience.org/library/papers/23230443	PubMed
6,976,417	Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors.	J Exp Med	1982	https://conductscience.org/library/papers/6976417	PubMed
6,973,434	Immunological evaluation of asymptomatic carriers of hepatitis B virus.	Clin Exp Immunol	1981	https://conductscience.org/library/papers/6973434	PubMed
6,973,000	Idiotypes on major histocompatibility complex-restricted virus-immune cytotoxic T lymphocytes.	J Exp Med	1981	https://conductscience.org/library/papers/6973000	PubMed
6,969,780	Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.	J Exp Med	1981	https://conductscience.org/library/papers/6969780	PubMed
6,967,451	Induction of cytolytic T- and B-cell responses against influenza virus infections.	Infect Immun	1980	https://conductscience.org/library/papers/6967451	PubMed
6,965,398	Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.	J Exp Med	1980	https://conductscience.org/library/papers/6965398	PubMed
6,096,476	Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.	J Exp Med	1984	https://conductscience.org/library/papers/6096476	PubMed
2,450,157	Overlapping T cell antigenic sites on a synthetic peptide fragment from herpes simplex virus glycoprotein D, the degenerate MHC restriction elicited, and functional evidence for antigen-Ia interaction.	J Exp Med	1988	https://conductscience.org/library/papers/2450157	PubMed
391,826	Lymphocytes. 2. Differentiation. Differentiation of lymphoid precursor cells.	J Clin Pathol Suppl (R Coll Pathol)	1979	https://conductscience.org/library/papers/391826	PubMed

1 to 10 of 27

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Genes0

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Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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