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Paper · 6969780

Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.

Kruisbeek AM and 2 others. J Exp Med, 1981. Cited by 46 papers, by iCite.

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ConductScience Library. Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development. Papers, record 6969780. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6969780

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.
PubMed
Journal
J Exp Med
PubMed
Year
1981
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
46
iCite
Relative citation ratio, by iCite
1.06
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kruisbeek AMA M
2Hodes RJR J
3Singer AA

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cytotoxicity, ImmunologicMajor topic
H-2 AntigensMajor topic
T-LymphocytesMajor topic
Thymus GlandMajor topic
Animals
Autoantigens
Bone Marrow
Immune Tolerance
Immunity, Cellular
Major Histocompatibility Complex
Male
Mice
Radiation Chimera
Spleen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
183,701Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.Immunol Rev1978https://conductscience.org/library/papers/83701PubMed
2102,728The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.J Exp Med1978https://conductscience.org/library/papers/102728PubMed
3216,768Primary anti-viral cytotoxic T-cell responses in semiallogeneic chimeras are not absolutely restricted to host H-2 type.J Exp Med1979https://conductscience.org/library/papers/216768PubMed
4156,219Search for suppression of T cells specific for the second nonhost H-2 haplotype in F1 leads to P irradiation bone marrow chimeras.J Immunol1979https://conductscience.org/library/papers/156219PubMed
5376,735Expression of MHC antigens by mouse thymic dendritic cells.J Immunol1979https://conductscience.org/library/papers/376735PubMed
6156,228The differentiation of cytotoxic T cells in vitro. I. Amplifying factor(s) in the primary response is Lyt 1 + cell dependent.J Immunol1979https://conductscience.org/library/papers/156228PubMed
7109,564Cellular and genetic control of antibody responses. V. Helper T-cell recognition of H-2 determinants on accessory cells but not B cells.J Exp Med1979https://conductscience.org/library/papers/109564PubMed
86,965,398Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.J Exp Med1980https://conductscience.org/library/papers/6965398PubMed
96,153,090Cellular and genetic control of antibody responses. VII. Absence of detectable suppression maintaining the H-2 restricted recognition of F1 leads to parent helper T cells.J Immunol1980https://conductscience.org/library/papers/6153090PubMed
10109,569H-2-linked genetic control of murine T-cell-mediated lympholysis to autologous cells modified with low concentrations of trinitrobenzene sulfonate.J Exp Med1979https://conductscience.org/library/papers/109569PubMed

1 to 10 of 35

See all 35 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 46 citations.

PMIDTitleJournalYearIn PapersSource
6,981,598Cell-mediated cytotoxicity to non-MHC alloantigens on mouse epidermal cells. VI. Influence of the MHC on the tissue specificity of cytotoxic T-lymphocyte responses.Immunogenetics1982https://conductscience.org/library/papers/6981598PubMed
6,979,047Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6979047PubMed
6,611,554The heterogeneity and functional capacities of human thymocyte subpopulations.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6611554PubMed
6,605,407Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens.J Exp Med1983https://conductscience.org/library/papers/6605407PubMed
6,222,135Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.J Exp Med1983https://conductscience.org/library/papers/6222135PubMed
6,217,271Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.J Exp Med1982https://conductscience.org/library/papers/6217271PubMed
6,201,586Trinitrophenyl modification of H-2k and H-2b spleen cells results in enhanced serological detection of Kk-like determinants.J Exp Med1984https://conductscience.org/library/papers/6201586PubMed
6,181,512Generation of the alloreactive T-cell repertoire: interaction of T-cell genotype and maturation environment.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6181512PubMed
2,991,416Allorestricted cytotoxic T cells. Large numbers of allo-H-2Kb-restricted antihapten and antiviral cytotoxic T cell populations clonally develop in vitro from murine splenic precursor T cells.J Exp Med1985https://conductscience.org/library/papers/2991416PubMed
1,584,760Selective manipulation of the human T-cell receptor repertoire expressed by thymocytes in organ culture.Proc Natl Acad Sci U S A1992https://conductscience.org/library/papers/1584760PubMed

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
HLA-C3,107PubTator's text mininghttps://conductscience.org/library/genes/3107NCBI Gene
IL23,558PubTator's text mininghttps://conductscience.org/library/genes/3558NCBI Gene
PPP1R1A5,502PubTator's text mininghttps://conductscience.org/library/genes/5502NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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