Paper · 83701

Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.

Zinkernagel RM. Immunol Rev, 1978. Cited by 315 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control. Papers, record 83701. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/83701

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.; PubMed
Journal: Immunol Rev; PubMed
Year: 1978; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S., Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/83701/; PubMed
DOI: https://doi.org/10.1111/j.1600-065x.1978.tb00264.x; PubMed
The journal: https://conductscience.org/library/journal-index/7702118; PubMed
Citations, by iCite: 315; iCite
Relative citation ratio, by iCite: 6.28; iCite
Revised in PubMed: 2019-09-11; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Zinkernagel RM	R M

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Genes, MHC Class II	Major topic
H-2 Antigens	Major topic
T-Lymphocytes	Major topic
Animals
Bone Marrow Cells
Cell Survival
Cytotoxicity, Immunologic
Epitopes
Immune Tolerance
Mice
Mice, Inbred Strains
Models, Biological
Polymorphism, Genetic
Radiation Chimera
Spleen
Thymus Gland

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by61

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 315 citations.

PMID	Title	Journal	Year	In Papers	Source
31,418,051	How does the immune system learn to distinguish between good and evil? The first definitive studies of T cell central tolerance and positive selection.	Immunogenetics	2019	https://conductscience.org/library/papers/31418051	PubMed
29,150,238	A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene.	Immunity	2017	https://conductscience.org/library/papers/29150238	PubMed
27,332,704	Using Clinical Trial Simulators to Analyse the Sources of Variance in Clinical Trials of Novel Therapies for Acute Viral Infections.	PLoS One	2016	https://conductscience.org/library/papers/27332704	PubMed
25,818,864	Codification of bidentate pMHC interaction with TCR and its co-receptor.	Trends Immunol	2015	https://conductscience.org/library/papers/25818864	PubMed
22,457,920	The spatial relationship of the viral and H-2 antigens recognized by anti-viral CTLs.	Immunogenetics	1980	https://conductscience.org/library/papers/22457920	PubMed
20,877,010	HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes.	J Clin Invest	2010	https://conductscience.org/library/papers/20877010	PubMed
19,118,203	The specificity of T cell regulation that enables self-nonself discrimination in the periphery.	Proc Natl Acad Sci U S A	2009	https://conductscience.org/library/papers/19118203	PubMed
10,393,953	On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells.	Proc Natl Acad Sci U S A	1999	https://conductscience.org/library/papers/10393953	PubMed
8,509,131	Characterization of a macrophage lineage cell colony-stimulating factor produced by thymic myoid cells.	Immunology	1993	https://conductscience.org/library/papers/8509131	PubMed
7,287,078	Quantitative variation in H-2-antigen expression. I. Estimation of H-2K and H-2D expression in different strains of mice.	Immunogenetics	1980	https://conductscience.org/library/papers/7287078	PubMed

1 to 10 of 61

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
INSR	3,643	PubTator's text mining	https://conductscience.org/library/genes/3643

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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