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Paper · 102728

The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.

Kappler JW and 1 other. J Exp Med, 1978. Cited by 164 papers, by iCite.

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ConductScience Library. The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression. Papers, record 102728. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/102728

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
164
iCite
Relative citation ratio, by iCite
2.71
iCite
Revised in PubMed
2019-05-08
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kappler JWJ W
2Marrack PP

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Genes, MHC Class IIMajor topic
H-2 AntigensMajor topic
Lymphocyte CooperationMajor topic
Major Histocompatibility ComplexMajor topic
T-LymphocytesMajor topic
Animals
B-Lymphocytes
Erythrocytes
Genetic Linkage
Hemocyanins
Immunologic Memory
Macrophages
Mice
Peptides

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,551,582Differential stimulation of precursor cells and carrier-specific thymus-derived cell activity in the in vivo reponse to heterologous erythrocytes in mice.J Immunol1972https://conductscience.org/library/papers/4551582PubMed
24,542,255Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene.J Exp Med1973https://conductscience.org/library/papers/4542255PubMed
34,652,871Cell transfer studies in a genetically controlled immune response.Eur J Immunol1972https://conductscience.org/library/papers/4652871PubMed
44,911,555An in vitro primary immune response to 2,4,6-trinitrophenyl substituted erythrocytes: response against carrier and hapten.J Immunol1970https://conductscience.org/library/papers/4911555PubMed
550,559Two genes in the major histocompatibility complex control immune response.Nature1975https://conductscience.org/library/papers/50559PubMed
652,686Collaboration of allogeneic T and B lymphocytes in the primary antibody response to sheep erythrocytes in vitro.J Exp Med1975https://conductscience.org/library/papers/52686PubMed
75,355,110Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.Proc Soc Exp Biol Med1969https://conductscience.org/library/papers/5355110PubMed
855,062The histocompatibility-linked immune response genes.Adv Cancer Res1975https://conductscience.org/library/papers/55062PubMed
958,030Antigen-specific and nonspecific mediatiors of T cell/B cell cooperation. II. Two helper T cells distinguished by their antigen sensitivities.J Immunol1976https://conductscience.org/library/papers/58030PubMed
1058,461T cell function in bone marrow chimeras: absence of host-reactive T cells and cooperation of helper T cells across allogeneic barriers.Transplant Rev1976https://conductscience.org/library/papers/58461PubMed

1 to 10 of 49

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Cited by41

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 164 citations.

PMIDTitleJournalYearIn PapersSource
29,148,973The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.Elife2017https://conductscience.org/library/papers/29148973PubMed
22,457,921T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.Immunogenetics1980https://conductscience.org/library/papers/22457921PubMed
22,345,700Positive selection in the thymus: an enigma wrapped in a mystery.J Immunol2012https://conductscience.org/library/papers/22345700PubMed
8,415,742An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells.Proc Natl Acad Sci U S A1993https://conductscience.org/library/papers/8415742PubMed
7,021,751
Role of the major histocompatibility complex in T cell activation of B cell subpopulations Lyb-5+ and Lyb-5- B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition.
J Exp Med1981https://conductscience.org/library/papers/7021751PubMed
6,991,911On the origin and mode of action of functionally distinct macrophage subpopulations.Mol Cell Biochem1980https://conductscience.org/library/papers/6991911PubMed
6,975,939Influence of H-2 antigen expression on killer T cell specificity, differentiation, and induction.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6975939PubMed
6,973,603Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted.J Exp Med1981https://conductscience.org/library/papers/6973603PubMed
6,969,780Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.J Exp Med1981https://conductscience.org/library/papers/6969780PubMed
6,965,398Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.J Exp Med1980https://conductscience.org/library/papers/6965398PubMed

1 to 10 of 41

See all 41 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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