Paper · 30628657

Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates microbiota dysbiosis in an experimental model of sepsis.

Chen L and 4 others. Int J Mol Med, 2019. Cited by 69 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates microbiota dysbiosis in an experimental model of sepsis. Papers, record 30628657. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30628657

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates microbiota dysbiosis in an experimental model of sepsis.; PubMed
Journal: Int J Mol Med; PubMed
Year: 2019; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/30628657/; PubMed
DOI: https://doi.org/10.3892/ijmm.2019.4050; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6365041/; PubMed
The journal: https://conductscience.org/library/journal-index/9810955; PubMed
Citations, by iCite: 69; iCite
Relative citation ratio, by iCite: 3.57; iCite
Revised in PubMed: 2022-12-07; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Chen L	Lufang
2	Li H	Hanyu
3	Li J	Jinyou
4	Chen Y	Yue
5	Yang Y	Yunmei

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Dysbiosis	Major topic
Gastrointestinal Microbiome	Major topic
Lacticaseibacillus rhamnosus	Major topic
Probiotics	Major topic
Sepsis	Major topic
Animals
Apoptosis
Biomarkers
Cell Proliferation
Colon
Disease Models, Animal
Male
Metagenome
Metagenomics
Mice
Mortality
Permeability
Phylogeny
RNA, Ribosomal, 16S

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	12,576,972	Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined.	Crit Care Med	2003	https://conductscience.org/library/papers/12576972	PubMed
2	16,456,446	Altered gut flora and environment in patients with severe SIRS.	J Trauma	2006	https://conductscience.org/library/papers/16456446	PubMed
3	17,183,312	An obesity-associated gut microbiome with increased capacity for energy harvest.	Nature	2006	https://conductscience.org/library/papers/17183312	PubMed
4	18,005,726	Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae.	Cell Host Microbe	2007	https://conductscience.org/library/papers/18005726	PubMed
5	18,279,948	Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial.	Lancet	2008	https://conductscience.org/library/papers/18279948	PubMed
6	19,131,954	Immunodesign of experimental sepsis by cecal ligation and puncture.	Nat Protoc	2009	https://conductscience.org/library/papers/19131954	PubMed
7	20,348,235	Human intestinal ischemia-reperfusion-induced inflammation characterized: experiences from a new translational model.	Am J Pathol	2010	https://conductscience.org/library/papers/20348235	PubMed
8	20,383,131	QIIME allows analysis of high-throughput community sequencing data.	Nat Methods	2010	https://conductscience.org/library/papers/20383131	PubMed
9	21,531,334	The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon.	Cell Metab	2011	https://conductscience.org/library/papers/21531334	PubMed
10	22,224,764	The microbiome in infectious disease and inflammation.	Annu Rev Immunol	2012	https://conductscience.org/library/papers/22224764	PubMed

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Cited by57

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 69 citations.

PMID	Title	Journal	Year	In Papers	Source
42,975,769	Beyond live probiotics: bioactivities, mechanisms, and application perspectives of Lacticaseibacillus rhamnosus cell-free supernatants.	World J Microbiol Biotechnol	2026	https://conductscience.org/library/papers/42975769	PubMed
42,611,135	Probiotics in Autoimmune Disease: Strain-specific Mechanisms and Therapeutic Perspectives.	Clin Rev Allergy Immunol	2026	https://conductscience.org/library/papers/42611135	PubMed
42,298,689	Dachaihu decoction alleviates septic liver injury by modulating the intestinal barrier dysfunction and suppressing the NF-κB/NLRP3/Caspase-1 signaling pathway.	Chin Med	2026	https://conductscience.org/library/papers/42298689	PubMed
42,191,736	Enhanced antimicrobial and anticancer properties of penicillin G-adapted Lacticaseibacillus rhamnosus GG against colorectal cancer cells.	Sci Rep	2026	https://conductscience.org/library/papers/42191736	PubMed
42,174,754	Effects of fecal microbiota transplantation and probiotics on the gut microbiome in antibiotic-treated septic patients: A pilot randomized controlled trial.	Virulence	2026	https://conductscience.org/library/papers/42174754	PubMed
41,234,694	Physical capacity modulates intestinal barrier dysfunction in functional disorders: phenotype-specific patterns in fibromyalgia and irritable bowel syndrome.	Front Physiol	2025	https://conductscience.org/library/papers/41234694	PubMed
41,007,387	Crosstalk Between Intestinal Microbiota and Host Defense Peptides in Fish.	Biology (Basel)	2025	https://conductscience.org/library/papers/41007387	PubMed
40,731,966	Disorders of Gut Microbiota and Plasma Metabolic Profiles May Be Associated with Lymph Node Tuberculosis.	Microorganisms	2025	https://conductscience.org/library/papers/40731966	PubMed
40,654,283	Gut microbiota and tuberculosis infection: interaction and therapeutic potential.	Gut Microbes	2025	https://conductscience.org/library/papers/40654283	PubMed
40,558,396	Anti-Inflammatory Function Analysis of Lacticaseibacillus rhamnosus CP-1 Strain Based on Whole-Genome Sequencing.	BioTech (Basel)	2025	https://conductscience.org/library/papers/40558396	PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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