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Paper · 306405

Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.

Eardley DD and 5 others. J Exp Med, 1978. Cited by 507 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition. Papers, record 306405. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/306405

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
507
iCite
Relative citation ratio, by iCite
11.8
iCite
Revised in PubMed
2021-12-03
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Eardley DDD D
2Hugenberger JJ
3McVay-Boudreau LL
4Shen FWF W
5Gershon RKR K
6Cantor HH

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Immunosuppression TherapyMajor topic
Lymphocyte CooperationMajor topic
T-LymphocytesMajor topic
Animals
Antibody Formation
Antibody-Producing Cells
Carrier Proteins
Erythrocytes
Feedback
Genetic Linkage
H-2 Antigens
Isoantigens
Mice

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References11

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
162,012Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses.J Exp Med1976https://conductscience.org/library/papers/62012PubMed
2306,406Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.J Exp Med1978https://conductscience.org/library/papers/306406PubMed
3300,350Lymphocytes as models for the study of mammalian cellular differentiation.Immunol Rev1977https://conductscience.org/library/papers/300350PubMed
44,123,363Delayed hypersensitivity: is the same population of thymus-derived cells responsible for cellular immunity reactions and the carrier effect?Immunol Commun1972https://conductscience.org/library/papers/4123363PubMed
558,934Induction of specific suppressor T cells in vitro.J Immunol1976https://conductscience.org/library/papers/58934PubMed
64,711,011List of congenic lines of mice. I. Lines with differences at alloantigen loci.Transplantation1973https://conductscience.org/library/papers/4711011PubMed
71,092,799Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.J Exp Med1975https://conductscience.org/library/papers/1092799PubMed
81,092,798Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.J Exp Med1975https://conductscience.org/library/papers/1092798PubMed
91,083,888
Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.
J Exp Med1976https://conductscience.org/library/papers/1083888PubMed
105,355,110Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.Proc Soc Exp Biol Med1969https://conductscience.org/library/papers/5355110PubMed

1 to 10 of 11

See all 11 references

Cited by145

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 507 citations.

PMIDTitleJournalYearIn PapersSource
42,259,915GPR15-guided CD8+ T regulatory cells control intestinal inflammation.Nature2026https://conductscience.org/library/papers/42259915PubMed
39,696,807Age-Dependent Bi-Phasic Dynamics of Ly49+CD8+ Regulatory T Cell Population.Aging Cell2025https://conductscience.org/library/papers/39696807PubMed
34,484,208CD8+ Regulatory T Cell - A Mystery to Be Revealed.Front Immunol2021https://conductscience.org/library/papers/34484208PubMed
32,421,955Advances in the Study of CD8+ Regulatory T Cells.Crit Rev Immunol2019https://conductscience.org/library/papers/32421955PubMed
31,569,411Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules.Int J Mol Sci2019https://conductscience.org/library/papers/31569411PubMed
23,432,802Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease.Am J Reprod Immunol2013https://conductscience.org/library/papers/23432802PubMed
22,136,694Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells.Semin Immunol2011https://conductscience.org/library/papers/22136694PubMed
21,671,120CD8(+) Tregs in autoimmunity: learning "self"-control from experience.Cell Mol Life Sci2011https://conductscience.org/library/papers/21671120PubMed
20,385,256CD8+ Tregs in lupus, autoimmunity, and beyond.Autoimmun Rev2010https://conductscience.org/library/papers/20385256PubMed
18,817,829Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone mice.Hum Immunol2008https://conductscience.org/library/papers/18817829PubMed

1 to 10 of 145

See all 145 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
HLA-E3,133PubTator's text mininghttps://conductscience.org/library/genes/3133

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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