Paper · 30808751

Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.

Litschko C and 14 others. Proc Natl Acad Sci U S A, 2019. Cited by 34 papers, by iCite.

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ConductScience Library. Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins. Papers, record 30808751. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30808751

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 2019; PubMed
Publication types: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/30808751/; PubMed
DOI: https://doi.org/10.1073/pnas.1821638116; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6397521/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 34; iCite
Relative citation ratio, by iCite: 1.2; iCite
Revised in PubMed: 2020-03-09; PubMed

Authors15

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Litschko C	Christof
2	Brühmann S	Stefan
3	Csiszár A	Agnes
4	Stephan T	Till
5	Dimchev V	Vanessa
6	Damiano-Guercio J	Julia
7	Junemann A	Alexander
8	Körber S	Sarah
9	Winterhoff M	Moritz
10	Nordholz B	Benjamin

1 to 10 of 15Source PubMed

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Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Actin Cytoskeleton	Major topic
Carrier Proteins	Major topic
Contractile Proteins	Major topic
Melanoma, Experimental	Major topic
Actins
Animals
CRISPR-Cas Systems
Cell Movement
Cell Polarity
Dictyostelium
Disease Models, Animal
Formins
Humans
Mice
Microscopy, Electron
Muscle Contraction
rhoA GTP-Binding Protein

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
094231/Z/10/Z	Wellcome Trust	United Kingdom		PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References63

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	15,908,944	The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia.	Nat Cell Biol	2005	https://conductscience.org/library/papers/15908944	PubMed
2	8,682,867	A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis.	J Cell Biol	1996	https://conductscience.org/library/papers/8682867	PubMed
3	11,222,756	The Dictyostelium discoideum family of Rho-related proteins.	Nucleic Acids Res	2001	https://conductscience.org/library/papers/11222756	PubMed
4	27,501,447	Focal Adhesion-Independent Cell Migration.	Annu Rev Cell Dev Biol	2016	https://conductscience.org/library/papers/27501447	PubMed
5	18,829,452	Specificity of interactions between mDia isoforms and Rho proteins.	J Biol Chem	2008	https://conductscience.org/library/papers/18829452	PubMed
6	1,732,064	Redundancy in the microfilament system: abnormal development of Dictyostelium cells lacking two F-actin cross-linking proteins.	Cell	1992	https://conductscience.org/library/papers/1732064	PubMed
7	22,114,350	Actin cross-linking proteins cortexillin I and II are required for cAMP signaling during Dictyostelium chemotaxis and development.	Mol Biol Cell	2012	https://conductscience.org/library/papers/22114350	PubMed
8	20,308,985	Organizing the cell cortex: the role of ERM proteins.	Nat Rev Mol Cell Biol	2010	https://conductscience.org/library/papers/20308985	PubMed
9	28,346,441	Altering the threshold of an excitable signal transduction network changes cell migratory modes.	Nat Cell Biol	2017	https://conductscience.org/library/papers/28346441	PubMed
10	25,017,211	Cellular control of cortical actin nucleation.	Curr Biol	2014	https://conductscience.org/library/papers/25017211	PubMed

1 to 10 of 63

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Cited by29

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 34 citations.

PMID	Title	Journal	Year	In Papers	Source
42,827,260	Daam-, FMNL-, and mDia-family formins jointly regulate cortical actin dynamics in melanoma cells.	Cell Commun Signal	2026	https://conductscience.org/library/papers/42827260	PubMed
42,697,882	The membrane-to-cortex distance regulates mDia1 activity to control cortical mechanics.	Nat Commun	2026	https://conductscience.org/library/papers/42697882	PubMed
41,888,658	Chemotactic motion of coronin-null cells with impaired actin turnover.	BMC Mol Cell Biol	2026	https://conductscience.org/library/papers/41888658	PubMed
40,843,611	Signaling and actin waves at a glance.	J Cell Sci	2025	https://conductscience.org/library/papers/40843611	PubMed
40,796,751	Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity.	Nat Commun	2025	https://conductscience.org/library/papers/40796751	PubMed
39,475,610	Decisive role of mDia-family formins in cell cortex function of highly adherent cells.	Sci Adv	2024	https://conductscience.org/library/papers/39475610	PubMed
37,851,146	Direct investigation of cell contraction signal networks by light-based perturbation methods.	Pflugers Arch	2023	https://conductscience.org/library/papers/37851146	PubMed
37,010,470	GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3.	J Cell Biol	2023	https://conductscience.org/library/papers/37010470	PubMed
36,980,231	Unleashed Actin Assembly in Capping Protein-Deficient B16-F1 Cells Enables Identification of Multiple Factors Contributing to Filopodium Formation.	Cells	2023	https://conductscience.org/library/papers/36980231	PubMed
36,897,976	Convergence of Ras- and Rac-regulated formin pathways is pivotal for phagosome formation and particle uptake in Dictyostelium.	Proc Natl Acad Sci U S A	2023	https://conductscience.org/library/papers/36897976	PubMed

1 to 10 of 29

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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