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Paper · 30850331

Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins.

Zhu Y and 8 others. Mol Cell, 2019. Cited by 80 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Papers, record 30850331. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30850331

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins.
PubMed
Journal
Mol Cell
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
80
iCite
Relative citation ratio, by iCite
2.48
iCite
Revised in PubMed
2024-07-20
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zhu YYalan
2Gao AAng
3Zhan QQi
4Wang YYong
5Feng HHan
6Liu SSongqing
7Gao GGuangxia
8Serganov AAlexander
9Gao PPu

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CRISPR-Associated Protein 9Major topic
CRISPR-Cas SystemsMajor topic
DNAMajor topic
Gene EditingMajor topic
Bacterial Proteins
Humans
Neisseria meningitidis

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R01 GM112940NIGMS NIH HHSUnited StatesR01GM112940PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References46

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
126,227,035Preparation and Crystallization of Riboswitches.Methods Mol Biol2016https://conductscience.org/library/papers/26227035PubMed
226,524,520Conformational control of DNA target cleavage by CRISPR-Cas9.Nature2015https://conductscience.org/library/papers/26524520PubMed
326,317,473Crystal Structure of Staphylococcus aureus Cas9.Cell2015https://conductscience.org/library/papers/26317473PubMed
427,145,843CRISPR/Cas9 in Genome Editing and Beyond.Annu Rev Biochem2016https://conductscience.org/library/papers/27145843PubMed
526,416,740Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins.Nature2015https://conductscience.org/library/papers/26416740PubMed
628,605,718Diversity, classification and evolution of CRISPR-Cas systems.Curr Opin Microbiol2017https://conductscience.org/library/papers/28605718PubMed
728,554,774Tubular lipid binding proteins (TULIPs) growing everywhere.Biochim Biophys Acta Mol Cell Res2017https://conductscience.org/library/papers/28554774PubMed
827,754,618Processing of X-ray diffraction data collected in oscillation mode.Methods Enzymol1997https://conductscience.org/library/papers/27754618PubMed
928,985,564Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.Cell2017https://conductscience.org/library/papers/28985564PubMed
1021,876,132Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions.Proc Natl Acad Sci U S A2011https://conductscience.org/library/papers/21876132PubMed

1 to 10 of 46

See all 46 references

Cited by57

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 80 citations.

PMIDTitleJournalYearIn PapersSource
42,804,049Plant viral suppressors HcPro and P19 inhibit CRISPR-Cas13-mediated transcript interference.Stress Biol2026https://conductscience.org/library/papers/42804049PubMed
42,662,772Structural insights into Cas9 inhibition by AcrIIA17 via bridge helix interaction.iScience2026https://conductscience.org/library/papers/42662772PubMed
41,832,226AcrIIA7 hijacks tracrRNA to block CRISPR-Cas system.Nat Commun2026https://conductscience.org/library/papers/41832226PubMed
41,430,372AcrIIA19 binds to the WED domain and inhibits various Cas9 orthologs at multiple stages.Commun Biol2025https://conductscience.org/library/papers/41430372PubMed
41,137,484Investigating the molecular mechanisms underlying the anti-CRISPR function of AcrIIA13b protein.FEBS J2026https://conductscience.org/library/papers/41137484PubMed
40,866,699One-shot design of functional protein binders with BindCraft.Nature2025https://conductscience.org/library/papers/40866699PubMed
40,332,149CRISPR-Cas Systems: A Functional Perspective and Innovations.Int J Mol Sci2025https://conductscience.org/library/papers/40332149PubMed
39,940,619Nano-Polymers as Cas9 Inhibitors.Polymers (Basel)2025https://conductscience.org/library/papers/39940619PubMed
39,399,829Current Updates of CRISPR/Cas System and Anti-CRISPR Proteins: Innovative Applications to Improve the Genome Editing Strategies.Int J Nanomedicine2024https://conductscience.org/library/papers/39399829PubMed
39,158,766Versatile plant genome engineering using anti-CRISPR-Cas12a systems.Sci China Life Sci2024https://conductscience.org/library/papers/39158766PubMed

1 to 10 of 57

See all 57 cited by

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ATP6V0A223,545PubTator's text mininghttps://conductscience.org/library/genes/23545NCBI Gene
IGKV2D-3028,881PubTator's text mininghttps://conductscience.org/library/genes/28881NCBI Gene
IGKV5-228,907PubTator's text mininghttps://conductscience.org/library/genes/28907NCBI Gene
MBP4,155PubTator's text mininghttps://conductscience.org/library/genes/4155NCBI Gene
NEDD94,739PubTator's text mininghttps://conductscience.org/library/genes/4739NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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