Paper311474

Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice.

Fernandes G and 5 others. Proc Natl Acad Sci U S A, 1979. Cited by 296 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. Papers, record 311474. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/311474

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1979; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/311474/; PubMed
DOI: https://doi.org/10.1073/pnas.76.1.457; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC382959/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 296; iCite
Relative citation ratio, by iCite: 9.11; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Fernandes G	G
2	Nair M	M
3	Onoe K	K
4	Tanaka T	T
5	Floyd R	R
6	Good RA	R A

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Immunity, Cellular	Major topic
Immunologic Deficiency Syndromes	Major topic
T-Lymphocytes	Major topic
Zinc	Major topic
Animals
Antibody Formation
Antibody-Dependent Cell Cytotoxicity
Antigens, Surface
Binding Sites
Cytotoxicity, Immunologic
Female
Immunoglobulin Fc Fragments
Male
Mice
Neoplasms, Experimental
Spleen

Source PubMed

Show 10 more topicsShow fewer topics

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	14,415,314	Zinc sulphate treatment of parakeratosis in cattle.	Nature	1960	https://conductscience.org/library/papers/14415314	PubMed
3	347,040	The effect of restricted dietary intake on the antibody mediated response of the zinc deficient A/J mouse.	J Nutr	1978	https://conductscience.org/library/papers/347040	PubMed
4	80,299	Natural killer cells in the mouse: an alternative immune surveillance mechanism?	Contemp Top Immunobiol	1978	https://conductscience.org/library/papers/80299	PubMed
5	77,993	Zinc and immunocompetence in protein-energy malnutrition.	Lancet	1978	https://conductscience.org/library/papers/77993	PubMed
6	72,960	Effect of zinc on thymus of recently malnourished children.	Lancet	1977	https://conductscience.org/library/papers/72960	PubMed
7	10,119	Age and genetic influence on immunity in NZB and autoimmune-resistant mice.	Clin Immunol Immunopathol	1976	https://conductscience.org/library/papers/10119	PubMed
8	340,468	Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays.	J Clin Invest	1978	https://conductscience.org/library/papers/340468	PubMed
9	333,066	Effect of zinc deficiency on the immune response of the young adult A/J mouse.	J Nutr	1977	https://conductscience.org/library/papers/333066	PubMed
10	311,006	Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations.	Proc Natl Acad Sci U S A	1978	https://conductscience.org/library/papers/311006	PubMed
11	299,761	Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: characterization of effector cells.	J Immunol	1977	https://conductscience.org/library/papers/299761	PubMed
12	279,277	New aspects in the control of food intake and appetite.	Ann N Y Acad Sci	1977	https://conductscience.org/library/papers/279277	PubMed
13	4,136,854	Letter: Acrodermatitis enteropathica: a lethal inherited human zinc-deficiency disorder.	Lancet	1974	https://conductscience.org/library/papers/4136854	PubMed
14	4,189,579	Plasma-zinc in health and disease.	Lancet	1970	https://conductscience.org/library/papers/4189579	PubMed
15	4,120,277	"Spontaneous" B cell activation due to loss of normal mouse serum suppressor.	Eur J Immunol	1972	https://conductscience.org/library/papers/4120277	PubMed
16	4,168,526	Plasma-zinc concentrations in patients with psoriasis, other dermatoses, and venous leg ulceration.	Lancet	1967	https://conductscience.org/library/papers/4168526	PubMed
17	4,279,272	Synergy between subpopulations of mouse spleen cells in the in vitro generation of cell-mediated cytotoxicity: evidence for the involvement of a non-T cell.	J Exp Med	1974	https://conductscience.org/library/papers/4279272	PubMed
18	4,205,493	Plasma and red cell water and elements in protein-calorie malnutrition.	Am J Clin Nutr	1974	https://conductscience.org/library/papers/4205493	PubMed
19	4,202,734	New aspects in the biological role of zinc: a stabilizer of macromolecules and biological membranes.	Life Sci	1973	https://conductscience.org/library/papers/4202734	PubMed
20	52,085	Letter: Zinc deficiency and cellular immune deficiency in acrodermatitis enteropathica in man and zinc deficiency with thymic hypoplasia in fresian calves: a possible genetic link.	Lancet	1975	https://conductscience.org/library/papers/52085	PubMed
21	4,509,185	Low levels of zinc in hair, anorexia, poor growth, and hypogeusia in children.	Pediatr Res	1972	https://conductscience.org/library/papers/4509185	PubMed

Show 14 more referencesShow fewer referencesSee all 32 references

Cited by53

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 296 citations.

PMID	Title	Journal	Year	In Papers	Source
39,833,533	Metabolic interplays between the tumour and the host shape the tumour macroenvironment.	Nat Rev Cancer	2025	https://conductscience.org/library/papers/39833533	PubMed
37,908,540	Antiviral activity of zinc against hepatitis viruses: current status and future prospects.	Front Microbiol	2023	https://conductscience.org/library/papers/37908540	PubMed
35,216,384	Zinc Status Impacts the Epidermal Growth Factor Receptor and Downstream Protein Expression in A549 Cells.	Int J Mol Sci	2022	https://conductscience.org/library/papers/35216384	PubMed
33,804,483	Zinc Source and Concentration Altered Physiological Responses of Beef Heifers during a Combined Viral-Bacterial Respiratory Challenge.	Animals (Basel)	2021	https://conductscience.org/library/papers/33804483	PubMed
33,375,275	Zinc Supplementation Modulates NETs Release and Neutrophils' Degranulation.	Nutrients	2020	https://conductscience.org/library/papers/33375275	PubMed
33,175,833	Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans.	PLoS Genet	2020	https://conductscience.org/library/papers/33175833	PubMed
31,546,724	Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms.	Nutrients	2019	https://conductscience.org/library/papers/31546724	PubMed
30,596,108	Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses.	J Immunol Res	2018	https://conductscience.org/library/papers/30596108	PubMed
29,439,479	Zinc and Skin Disorders.	Nutrients	2018	https://conductscience.org/library/papers/29439479	PubMed
29,123,159	Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice.	Sci Rep	2017	https://conductscience.org/library/papers/29123159	PubMed
29,065,550	Metallothioneins: Emerging Modulators in Immunity and Infection.	Int J Mol Sci	2017	https://conductscience.org/library/papers/29065550	PubMed
27,872,866	Roles of Zinc Signaling in the Immune System.	J Immunol Res	2016	https://conductscience.org/library/papers/27872866	PubMed
25,878,905	Zinc in gut-brain interaction in autism and neurological disorders.	Neural Plast	2015	https://conductscience.org/library/papers/25878905	PubMed
21,660,546	Zinc homeostasis and signaling in health and diseases: Zinc signaling.	J Biol Inorg Chem	2011	https://conductscience.org/library/papers/21660546	PubMed
21,660,402	The efficacy of zinc supplementation on outcome of children with severe pneumonia. A randomized double-blind placebo-controlled clinical trial.	Indian J Pediatr	2011	https://conductscience.org/library/papers/21660402	PubMed
21,602,277	Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore.	J Biol Chem	2011	https://conductscience.org/library/papers/21602277	PubMed
19,487,731	The EVER proteins as a natural barrier against papillomaviruses: a new insight into the pathogenesis of human papillomavirus infections.	Microbiol Mol Biol Rev	2009	https://conductscience.org/library/papers/19487731	PubMed
19,451,265	Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction.	J Exp Med	2009	https://conductscience.org/library/papers/19451265	PubMed
18,953,657	Micronutrient deficiencies in maternity and child health: a review of environmental and social context and implications for Malawi.	Environ Geochem Health	2009	https://conductscience.org/library/papers/18953657	PubMed
18,754,861	Intracellular zinc homeostasis and zinc signaling.	Cancer Sci	2008	https://conductscience.org/library/papers/18754861	PubMed

Show 14 more cited byShow fewer cited bySee all 53 cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Grants
Trials
Comments and corrections
Genes
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/311474

GET https://conductscience.org/api/papers/v1/311474/references?page=2

API reference For AI assistants