Paper · 31455640

Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure.

Creekmore BC and 8 others. mSystems, 2019. Cited by 50 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure. Papers, record 31455640. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31455640

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure.; PubMed
Journal: mSystems; PubMed
Year: 2019; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/31455640/; PubMed
DOI: https://doi.org/10.1128/msystems.00452-19; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6712278/; PubMed
The journal: https://conductscience.org/library/journal-index/101680636; PubMed
Citations, by iCite: 50; iCite
Relative citation ratio, by iCite: 2.35; iCite
Revised in PubMed: 2024-09-22; PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Creekmore BC	Benjamin C
2	Gray JH	Josh H	https://orcid.org/0000-0002-3388-5867
3	Walton WG	William G
4	Biernat KA	Kristen A
5	Little MS	Michael S
6	Xu Y	Yongmei
7	Liu J	Jian
8	Gharaibeh RZ	Raad Z
9	Redinbo MR	Matthew R	https://orcid.org/0000-0003-0814-5346

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R01 CA098468	NCI NIH HHS	United States	R01CA098468	PubMed	NIH RePORTER
R01 CA207416	NCI NIH HHS	United States	R01CA207416	PubMed	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	12,876,315	Prediction of lipoprotein signal peptides in Gram-negative bacteria.	Protein Sci	2003	https://conductscience.org/library/papers/12876315	PubMed
2	18,503,031	Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding.	J Lipid Res	2008	https://conductscience.org/library/papers/18503031	PubMed
3	18,926,603	High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model.	Neurobiol Aging	2010	https://conductscience.org/library/papers/18926603	PubMed
4	20,508,158	Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation.	Am J Physiol Gastrointest Liver Physiol	2010	https://conductscience.org/library/papers/20508158	PubMed
5	20,808,947	High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.	PLoS One	2010	https://conductscience.org/library/papers/20808947	PubMed
6	21,051,639	Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.	Science	2010	https://conductscience.org/library/papers/21051639	PubMed
7	21,169,495	Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil.	J Bacteriol	2011	https://conductscience.org/library/papers/21169495	PubMed
8	21,742,017	High-fat diet selectively protects against the effects of chronic social stress in the mouse.	Neuroscience	2011	https://conductscience.org/library/papers/21742017	PubMed
9	21,988,835	Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega.	Mol Syst Biol	2011	https://conductscience.org/library/papers/21988835	PubMed
10	2,231,712	Basic local alignment search tool.	J Mol Biol	1990	https://conductscience.org/library/papers/2231712	PubMed

1 to 10 of 28

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Cited by33

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 50 citations.

PMID	Title	Journal	Year	In Papers	Source
42,231,021	Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility.	Nat Neurosci	2026	https://conductscience.org/library/papers/42231021	PubMed
42,161,945	Glucuronidation metabolomic fingerprinting to map host-microbe metabolism.	Nat Commun	2026	https://conductscience.org/library/papers/42161945	PubMed
41,999,613	Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk.	Cancer Prev Res (Phila)	2026	https://conductscience.org/library/papers/41999613	PubMed
41,853,525	The microbiome: a link between obesity and breast cancer risk.	Front Microbiomes	2024	https://conductscience.org/library/papers/41853525	PubMed
41,752,380	β-Glucuronidase at the Microbiota-Host Interface: Dual Regulatory Roles and Precision Modulation by Natural Products.	Molecules	2026	https://conductscience.org/library/papers/41752380	PubMed
41,608,689	Bilirubin-microbiota interaction: molecular mechanisms and therapeutic strategies in neonatal jaundice.	Front Microbiol	2025	https://conductscience.org/library/papers/41608689	PubMed
41,513,699	The testobolome in microbial testosterone metabolism and human health.	NPJ Biofilms Microbiomes	2026	https://conductscience.org/library/papers/41513699	PubMed
41,310,366	Gut microbial β-glucuronidases and their role in the microbiome-metabolite axis in colorectal cancer.	Nat Commun	2025	https://conductscience.org/library/papers/41310366	PubMed
41,155,243	Estrogenic Effect of Probiotics on Anxiety and Depression: A Narrative Review.	Int J Mol Sci	2025	https://conductscience.org/library/papers/41155243	PubMed
38,295,186	Integrating the gut microbiome and pharmacology.	Sci Transl Med	2024	https://conductscience.org/library/papers/38295186	PubMed

1 to 10 of 33

See all 33 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
GUSB	2,990	PubTator's text mining	https://conductscience.org/library/genes/2990

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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