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Paper · 315987

Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.

Watson J and 4 others. J Exp Med, 1979. Cited by 446 papers, by iCite.

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ConductScience Library. Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines. Papers, record 315987. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/315987

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.
PubMed
Journal
J Exp Med
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
446
iCite
Relative citation ratio, by iCite
10.5
iCite
Revised in PubMed
2019-05-08
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Watson JJ
2Gillis SS
3Marbrook JJ
4Mochizuki DD
5Smith KAK A

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
LymphokinesMajor topic
Animals
Chromatography, Gel
Chromatography, Ion Exchange
Concanavalin A
Culture Techniques
Cytotoxicity Tests, Immunologic
Female
Isoelectric Focusing
Lymphocyte Activation
Mice
Spleen
T-Lymphocytes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1233,910A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors.J Exp Med1977https://conductscience.org/library/papers/233910PubMed
284,015Biochemical relationship between murine immune interferon and a killer cell helper factor.J Immunol1979https://conductscience.org/library/papers/84015PubMed
370,488Activation of T and B lymphocytes in vitro. VI. Biochemical and physicochemical characterization of the allogeneic effect factor.J Immunol1977https://conductscience.org/library/papers/70488PubMed
470,359In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.Eur J Immunol1977https://conductscience.org/library/papers/70359PubMed
575,173Partial characterization and purification of murine T cell-replacing factor, TRF. II. Biochemical characteristics.Immunochemistry1978https://conductscience.org/library/papers/75173PubMed
669,003In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells.J Exp Med1977https://conductscience.org/library/papers/69003PubMed
7149,174Effects of costimulator on immune responses in vitro.J Immunol1978https://conductscience.org/library/papers/149174PubMed
8152,789The effect of T cell growth factor on the generation of cytolytic T cells.J Immunol1978https://conductscience.org/library/papers/152789PubMed
9145,543Long term culture of tumour-specific cytotoxic T cells.Nature1977https://conductscience.org/library/papers/145543PubMed
10109,511Molecular and quantitative analysis of helper T cell-replacing factors on the induction of antigen-sensitive B and T lymphocytes.J Immunol1979https://conductscience.org/library/papers/109511PubMed

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Cited by78

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 446 citations.

PMIDTitleJournalYearIn PapersSource
29,443,657IL-2 and Beyond in Cancer Immunotherapy.J Interferon Cytokine Res2018https://conductscience.org/library/papers/29443657PubMed
27,226,996The history of fever, leukocytic pyrogen and interleukin-1.Temperature (Austin)2015https://conductscience.org/library/papers/27226996PubMed
25,037,233Requirement of dual stimulation by homologous recombinant IL-2 and recombinant IL-12 for the in vitro production of interferon gamma by canine peripheral blood mononuclear cells.BMC Res Notes2014https://conductscience.org/library/papers/25037233PubMed
6,984,670Lethal effect of the intravenous injection of H-2 alloantigen activated T cells.Clin Exp Immunol1982https://conductscience.org/library/papers/6984670PubMed
6,983,561Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.J Exp Med1982https://conductscience.org/library/papers/6983561PubMed
6,983,069Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6983069PubMed
6,982,303Correlated expression of T cell growth factor dependence, sensitivity to Vicia villosa lectin, and cytolytic activity in hybrids between cytolytic T cells and T lymphomas.J Exp Med1982https://conductscience.org/library/papers/6982303PubMed
6,980,414Long-term culture of B lymphocytes and their precursors from murine bone marrow.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6980414PubMed
6,980,256Purification of human interleukin 2 to apparent homogeneity and its molecular heterogeneity.J Exp Med1982https://conductscience.org/library/papers/6980256PubMed
6,979,751Purification and initial characterization of rat interleukin 2.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6979751PubMed

1 to 10 of 78

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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