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Paper · 6983069

Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.

Pike BL and 4 others. Proc Natl Acad Sci U S A, 1982. Cited by 95 papers, by iCite.

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ConductScience Library. Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor. Papers, record 6983069. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6983069

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1982
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
95
iCite
Relative citation ratio, by iCite
1.79
iCite
Revised in PubMed
2019-05-01
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Pike BLB L
2Vaux DLD L
3Clark-Lewis II
4Schrader JWJ W
5Nossal GJG J

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
Growth SubstancesMajor topic
T-LymphocytesMajor topic
Animals
Cell Division
Cells, Cultured
Clone Cells
Haptens
Interleukin-4
Lymphocyte Activation
Mice

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References25

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,033,418Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).J Exp Med1972https://conductscience.org/library/papers/5033418PubMed
24,128,440
Mechanism of activation of the bone marrow-derived lymphocyte. 3. A distinction between a macrophage-produced triggering signal and the amplifying effect on triggered B lymphocytes of allogeneic interactions.
J Exp Med1973https://conductscience.org/library/papers/4128440PubMed
34,606,516Enhancement of the humoral response of T cell-depleted murine spleens by a factor derived from human monocytes in vitro.J Immunol1974https://conductscience.org/library/papers/4606516PubMed
41,094,630A third signal in B cell activation given by TRF.Transplant Rev1975https://conductscience.org/library/papers/1094630PubMed
557,094Single cell studies on the antibody-forming potential of fractionated, hapten-specific B lymphocytes.Immunology1976https://conductscience.org/library/papers/57094PubMed
61,083,394The nature of the cells generating B-lymphocyte colonies in vitro.J Cell Physiol1976https://conductscience.org/library/papers/1083394PubMed
7303,681Regulation of B-lymphocyte clonal proliferation by stimulatory and inhibitory macrophage-derived factors.J Exp Med1977https://conductscience.org/library/papers/303681PubMed
8304,866Improved procedure for the fraction and in vitro stimulation of hapten-specific B lymphocytes.J Immunol1978https://conductscience.org/library/papers/304866PubMed
9350,592Sequential use of hapten-gelatin fractionation and fluorescence-activated cell sorting in the enrichment of hapten-specific B llymphocytes.Eur J Immunol1978https://conductscience.org/library/papers/350592PubMed
10112,040Mechanisms of clonal abortion tolerogenesis. II. Clonal behaviour of immature B cells following exposure to anti-mu chain antibody.Immunology1979https://conductscience.org/library/papers/112040PubMed

1 to 10 of 25

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Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 95 citations.

PMIDTitleJournalYearIn PapersSource
34,322,133Exploiting Single-Cell Tools in Gene and Cell Therapy.Front Immunol2021https://conductscience.org/library/papers/34322133PubMed
6,604,127Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.J Exp Med1983https://conductscience.org/library/papers/6604127PubMed
6,434,689Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.J Exp Med1984https://conductscience.org/library/papers/6434689PubMed
6,334,854Human interleukin 2 can promote the growth and differentiation of single hapten-specific B cells in the presence of specific antigen.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6334854PubMed
6,232,611Single-cell studies on hapten-specific B cells: response to T-cell-dependent antigens.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6232611PubMed
6,227,678Dendritic cells induce T lymphocytes to release B cell-stimulating factors by an interleukin 2-dependent mechanism.J Exp Med1983https://conductscience.org/library/papers/6227678PubMed
6,092,511Expression of interleukin 2 receptors on activated human B cells.J Exp Med1984https://conductscience.org/library/papers/6092511PubMed
6,089,211Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte activation.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6089211PubMed
3,889,907A high-efficiency cloning system for single hapten-specific B lymphocytes that is suitable for assay of putative growth and differentiation factors.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3889907PubMed
3,877,937Interleukin 1 can act as a B-cell growth and differentiation factor.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/3877937PubMed

1 to 10 of 22

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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