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Paper · 57094

Single cell studies on the antibody-forming potential of fractionated, hapten-specific B lymphocytes.

Nossal GJ and 1 other. Immunology, 1976. Cited by 101 papers, by iCite.

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ConductScience Library. Single cell studies on the antibody-forming potential of fractionated, hapten-specific B lymphocytes. Papers, record 57094. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/57094

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Single cell studies on the antibody-forming potential of fractionated, hapten-specific B lymphocytes.
PubMed
Journal
Immunology
PubMed
Year
1976
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
101
iCite
Relative citation ratio, by iCite
2.05
iCite
Revised in PubMed
2018-11-13
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Nossal GJG J
2Pike BLB L

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibody-Producing CellsMajor topic
B-LymphocytesMajor topic
HaptensMajor topic
Animals
Antibody Formation
Binding Sites
Cell Fractionation
Clone Cells
Epitopes
Flagellin
Hemolytic Plaque Technique
Male
Mice
Mice, Inbred CBA
Nitrohydroxyiodophenylacetate

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,604,502Generation of antibody diversity. I. Kinetics of production of different antibody specificities during the course of an immune response.Eur J Immunol1974https://conductscience.org/library/papers/4604502PubMed
24,605,292The mechanism of bone marrow-derived (B) lymphocyte activation. II. A "second signal" for antigen-specific activation provided by flagellin and lipopolysaccharide.Eur J Immunol1974https://conductscience.org/library/papers/4605292PubMed
34,609,772The generation of antibody diversity. III. Variation in the specificity of antibody produced within single clones of antibody-forming cells in vitro.Eur J Immunol1974https://conductscience.org/library/papers/4609772PubMed
44,615,807The in vitro response to sheep erythrocytes by mouse spleen cells: segregation of distinct events leading to antibody formation.Cell Immunol1974https://conductscience.org/library/papers/4615807PubMed
547,891Separation of antigen-specific lymphocytes. I. Enrichment of antigen-binding cells.J Exp Med1975https://conductscience.org/library/papers/47891PubMed
65,105,952Antibody-mediated suppression of the immune response in vitro. 3. Low zone tolerance in vitro.Immunology1971https://conductscience.org/library/papers/5105952PubMed
75,471,044Studies on colony formation in vitro by mouse bone marrow cells. II. Action of colony stimulating factor.J Cell Physiol1970https://conductscience.org/library/papers/5471044PubMed
85,653,817Further improvements in the plaque technique for detecting single antibody-forming cells.Immunology1968https://conductscience.org/library/papers/5653817PubMed
95,691,987Cell to cell interaction in the immune response. 3. Chromosomal marker analysis of single antibody-forming cells in reconstituted, irradiated, or thymectomized mice.J Exp Med1968https://conductscience.org/library/papers/5691987PubMed
10770,314Estimation of hapten-specific antibody-forming cell precursors in microcultures.Immunology1976https://conductscience.org/library/papers/770314PubMed

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Cited by25

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 101 citations.

PMIDTitleJournalYearIn PapersSource
17,878,906One cell-one antibody: prelude and aftermath.Nat Immunol2007https://conductscience.org/library/papers/17878906PubMed
8,464,928Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization.Proc Natl Acad Sci U S A1993https://conductscience.org/library/papers/8464928PubMed
6,983,069Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6983069PubMed
6,968,812Relative sensitivity of fetal and newborn mice to induction of hapten-specific B cell tolerance.J Exp Med1980https://conductscience.org/library/papers/6968812PubMed
6,966,401Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6966401PubMed
6,804,951Clonal anergy: the universally anergic B lymphocyte.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6804951PubMed
6,455,666Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6455666PubMed
6,334,854Human interleukin 2 can promote the growth and differentiation of single hapten-specific B cells in the presence of specific antigen.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6334854PubMed
6,232,611Single-cell studies on hapten-specific B cells: response to T-cell-dependent antigens.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6232611PubMed
6,174,979Antibody production by single, hapten-specific B lymphocytes: an antigen-driven cloning system free of filler or accessory cells.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6174979PubMed

1 to 10 of 25

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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