Paper · 6966401

Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen.

Nossal GJ and 1 other. Proc Natl Acad Sci U S A, 1980. Cited by 222 papers, by iCite.

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ConductScience Library. Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Papers, record 6966401. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6966401

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1980; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6966401/; PubMed
DOI: https://doi.org/10.1073/pnas.77.3.1602; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC348545/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 222; iCite
Relative citation ratio, by iCite: 3.54; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Nossal GJ	G J
2	Pike BL	B L

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
B-Lymphocytes	Major topic
Clone Cells	Major topic
Immune Tolerance	Major topic
Animals
Animals, Newborn
Antibody Formation
Binding Sites
Cell Separation
Female
Fluoresceins
Maternal-Fetal Exchange
Mice
Pregnancy
Receptors, Antigen, B-Cell

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	5,809,807	Binding of 125I-BSA to lymphoid cells of tolerant mice.	Int Arch Allergy Appl Immunol	1969	https://conductscience.org/library/papers/5809807	PubMed
2	5,013,444	Fluorescence activated cell sorting.	Rev Sci Instrum	1972	https://conductscience.org/library/papers/5013444	PubMed
3	4,119,591	Fate of antigen-binding cells in unresponsive and immune mice.	J Exp Med	1973	https://conductscience.org/library/papers/4119591	PubMed
4	4,541,832	Studies on the differentiation of B lymphocytes in the mouse.	Immunology	1973	https://conductscience.org/library/papers/4541832	PubMed
5	4,200,173	Development and application of a rapid cell sorter.	Clin Chem	1973	https://conductscience.org/library/papers/4200173	PubMed
6	4,594,416	The tolerant cell: direct evidence for receptor blockade by tolerogen.	J Immunol	1974	https://conductscience.org/library/papers/4594416	PubMed
7	47,889	Evidence for the clonal abortion theory of B-lymphocyte tolerance.	J Exp Med	1975	https://conductscience.org/library/papers/47889	PubMed
8	47,891	Separation of antigen-specific lymphocytes. I. Enrichment of antigen-binding cells.	J Exp Med	1975	https://conductscience.org/library/papers/47891	PubMed
9	1,080,547	Receptor-mediated inactivation of early B lymphocytes.	Nature	1975	https://conductscience.org/library/papers/1080547	PubMed
10	811,748	Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self.	J Exp Med	1975	https://conductscience.org/library/papers/811748	PubMed

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Cited by70

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 222 citations.

PMID	Title	Journal	Year	In Papers	Source
42,859,222	Viral subversion of B-cell tolerance: mechanisms linking infection to autoimmunity.	EMBO Rep	2026	https://conductscience.org/library/papers/42859222	PubMed
41,410,768	Convergent mutation trajectories convert functional self-tolerance in IGHV4-34 B cells to genetic tolerance encoded in the antibody.	Proc Natl Acad Sci U S A	2025	https://conductscience.org/library/papers/41410768	PubMed
40,529,617	Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets.	MedComm (2020)	2025	https://conductscience.org/library/papers/40529617	PubMed
39,950,084	Immune Tolerance Regulation Is Critical to Immune Homeostasis.	J Immunol Res	2025	https://conductscience.org/library/papers/39950084	PubMed
36,705,415	4-1BB and cytokines trigger human NK, γδ T, and CD8+ T cell proliferation and activation, but are not required for their effector functions.	Immun Inflamm Dis	2023	https://conductscience.org/library/papers/36705415	PubMed
36,357,486	NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance.	Commun Biol	2022	https://conductscience.org/library/papers/36357486	PubMed
35,128,676	Role of inhibitory signaling in peripheral B cell tolerance.	Immunol Rev	2022	https://conductscience.org/library/papers/35128676	PubMed
34,937,915	The foundations of immune checkpoint blockade and the ipilimumab approval decennial.	Nat Rev Drug Discov	2022	https://conductscience.org/library/papers/34937915	PubMed
34,557,181	From Infection to Immunity: Understanding the Response to SARS-CoV2 Through In-Silico Modeling.	Front Immunol	2021	https://conductscience.org/library/papers/34557181	PubMed
34,434,193	Primary Immune Responses and Affinity Maturation Are Controlled by IgD.	Front Immunol	2021	https://conductscience.org/library/papers/34434193	PubMed

1 to 10 of 70

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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